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2-Fluoro-4-hydroxybenzoic acid

2-Fluoro-4-hydroxybenzoic acid Structure
2-Fluoro-4-hydroxybenzoic acid structure
CAS No.
65145-13-3
Chemical Name:
2-Fluoro-4-hydroxybenzoic acid
Synonyms
RARECHEM AL BO 0814;4-Carboxy-3-fluorophenol;2-FLUORO-4-HYDROXYBENZOIC ACID;2-Fluoro-4-hydroxybenzoicAcid>Benzoicacid, 2-fluoro-4-hydroxy-
CBNumber:
CB8415156
Molecular Formula:
C7H5FO3
Molecular Weight:
156.11
MDL Number:
MFCD01310985
MOL File:
65145-13-3.mol
Last updated:2025-07-24 18:13:54
Product description Number Pack Size Price
2-Fluoro-4-hydroxybenzoic acid AldrichCPR CDS002815 100 mg $73.1
2-Fluoro-4-hydroxybenzoic Acid >98.0%(GC)(T) F0571 5g $44
2-Fluoro-4-hydroxybenzoic Acid >98.0%(GC)(T) F0571 25g $177
2-Fluoro-4-hydroxybenzoic Acid F591645 2.5g $120
2-Fluoro-4-hydroxybenzoic Acid F591645 25g $360
More product size
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2-Fluoro-4-hydroxybenzoic acid Properties

Melting point 199-202
Boiling point 334.6±27.0 °C(Predicted)
Density 1.492±0.06 g/cm3(Predicted)
storage temp. RT, stored under nitrogen
solubility soluble in Methanol
form powder to crystal
pka 3?+-.0.10(Predicted)
color White to Almost white
CAS DataBase Reference 65145-13-3(CAS DataBase Reference)
UNSPSC Code 12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36
HazardClass  IRRITANT
HS Code  2918290090
NFPA 704
0
1 0

2-Fluoro-4-hydroxybenzoic acid price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS002815 2-Fluoro-4-hydroxybenzoic acid AldrichCPR 100 mg $73.1 2025-07-31 Buy
TCI Chemical F0571 2-Fluoro-4-hydroxybenzoic Acid >98.0%(GC)(T) 65145-13-3 5g $44 2025-07-31 Buy
TCI Chemical F0571 2-Fluoro-4-hydroxybenzoic Acid >98.0%(GC)(T) 65145-13-3 25g $177 2025-07-31 Buy
TRC F591645 2-Fluoro-4-hydroxybenzoic Acid 65145-13-3 2.5g $120 2021-12-16 Buy
TRC F591645 2-Fluoro-4-hydroxybenzoic Acid 65145-13-3 25g $360 2021-12-16 Buy
Product number Packaging Price Buy
CDS002815 100 mg $73.1 Buy
F0571 5g $44 Buy
F0571 25g $177 Buy
F591645 2.5g $120 Buy
F591645 25g $360 Buy

2-Fluoro-4-hydroxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

Pale yellow liquid

Uses

2-Fluoro-4-hydroxybenzoic Acid, is a fluorinated building block used for the synthesis of more complex pharmaceutical and biologically active compounds. It is also fluorine substituted 4-hydroxybenzoates, which has been shown to have antioxidant activity.

Synthesis

2-Fluoro-4-hydroxybenzonitrile

82380-18-5

2-Fluoro-4-hydroxybenzoic acid

65145-13-3

General procedure for the synthesis of 2-fluoro-4-hydroxybenzoic acid from 2-fluoro-4-hydroxybenzonitrile: To a stirred solution of 2-fluoro-4-hydroxybenzonitrile (20.00 g, 145.9 mmol) in 160 mL of water was slowly added an aqueous 50% sodium hydroxide solution (40.00 g, 500.0 mmol). The reaction mixture was heated to reflux for 4 hours and subsequently cooled to room temperature. The cooled mixture was slowly poured into ice-cold concentrated hydrochloric acid and extracted with ether. The aqueous phase was adjusted to alkaline with saturated aqueous sodium bicarbonate, extracted again with ether and the ether layer was discarded. The aqueous phase was acidified with concentrated hydrochloric acid to pH < 2 and then extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2-fluoro-4-hydroxybenzoic acid as a white solid (22.90 g, 100% yield). The product was characterized by 1H NMR (300 MHz, CD3COCD3) and 19F-NMR (300 MHz, CD3COCD3) with the following data: 1H NMR δ (ppm): 9.80 (b, 1H), 7.87 (t, 1H), 6.77 (dd, 1H), 6.66 (dd, 1H); 19F-NMR δ (ppm): -108.13 (s, decoupled).

References

[1] Patent: US2006/20146, 2006, A1. Location in patent: Page/Page column 30
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1981, vol. 67, p. 1 - 24
[3] Patent: US6369261, 2002, B1. Location in patent: Page column 25

2-Fluoro-4-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

2-Fluoro-4-hydroxybenzonitrile Hydrochloric acid Sodium hydroxide

Preparation Products

METHYL 2-FLUORO-4-HYDROXYBENZOATE 2-Fluoro-4-methoxybenzoylchloride 2-Fluoro-4-methoxybenzoic acid 2-FLUORO-4-N-HEXYLOXYBENZOIC ACID 3-fluoro-4-(hydroxymethyl)phenol

2-Fluoro-4-hydroxybenzoic acid Suppliers

Global( 227)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13493 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29847 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Nanjing jinheyou Trading Co., Ltd. 		15705188088 admin@jheyou.com CHINA 1268 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Shanghai Safer Pharmaceutical Technology Co., Ltd. 		021-31761238 sales@saferph.com CHINA 897 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14359 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
Nanjing jinheyou Trading Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shanghai Safer Pharmaceutical Technology Co., Ltd. 		58
Win-Win chemical CO., Limited 		58

View Lastest Price from 2-Fluoro-4-hydroxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-4-hydroxybenzoic acid pictures 2021-07-13 2-Fluoro-4-hydroxybenzoic acid
65145-13-3
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2-Fluoro-4-hydroxybenzoic acid pictures 2021-07-10 2-Fluoro-4-hydroxybenzoic acid
65145-13-3
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2-Fluoro-4-hydroxybenzoic acid pictures 2019-12-11 2-Fluoro-4-hydroxybenzoic acid
65145-13-3
 US $0.00 / g 1g 95%min 20kg/month Nanjing jinheyou Trading Co., Ltd.

2-Fluoro-4-hydroxybenzoic acid Spectrum

2-Fluoro-4-hydroxybenzoic acid(65145-13-3)1HNMR

65145-13-3(2-Fluoro-4-hydroxybenzoic acid)Related Search:

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RARECHEM AL BO 0814 2-FLUORO-4-HYDROXYBENZOIC ACID 4-Carboxy-3-fluorophenol Benzoicacid, 2-fluoro-4-hydroxy- 2-Fluoro-4-hydroxybenzoicAcid> 65145-13-3 C7H5O3F Fluorine series FINE Chemical & INTERMEDIATES Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Acids & Esters Fluorine Compounds Phenols