DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE
- CAS No.
- 122194-07-4
- Chemical Name:
- DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE
- Synonyms
- dimethyl diisopropylphosphoramidite;DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE;DIMETHYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE;Dimethyl N,N-diisopropylphosphoramidite >=95.0% (GC);Dimethyl N,N-diisopropylphosphoramidite;Phosphoramidous acid, N,N-bis(1-methylethyl)-, dimethyl ester
- CBNumber:
- CB8440943
- Molecular Formula:
- C8H20NO2P
- Molecular Weight:
- 193.22
- MDL Number:
- MFCD00153505
- MOL File:
- 122194-07-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dimethyl N,N-diisopropylphosphoramidite | D472500 | 5g | $185 |
| Dimethyl N,N-diisopropylphosphoramidite | FD22252 | 10g | $275 |
| Dimethyl N,N-diisopropylphosphoramidite 97% | AK186440 | 5g | $293 |
| Dimethyl N,N-diisopropylphosphoramidite 97% | OR963457 | 5g | $363 |
| Dimethyl N,N-diisopropylphosphoramidite | Z8605 | 10g | $549 |
| Boiling point | 54 °C10 mm Hg(lit.) |
|---|---|
| Density | 0.840 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 100 °C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Sparingly) |
| form | Oil |
| color | Clear Colourless |
| Stability | Moisture Sensitive |
| InChI | 1S/C8H20NO2P/c1-7(2)9(8(3)4)12(10-5)11-6/h7-8H,1-6H3 |
| InChIKey | KXUMNSXPAYCKPR-UHFFFAOYSA-N |
| SMILES | COP(OC)N(C(C)C)C(C)C |
| UNSPSC Code | 12352116 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 2929 90 00 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D472500 | Dimethyl N,N-diisopropylphosphoramidite | 122194-07-4 | 5g | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD22252 | Dimethyl N,N-diisopropylphosphoramidite | 122194-07-4 | 10g | $275 | 2021-12-16 | Buy |
| Ark Pharm | AK186440 | Dimethyl N,N-diisopropylphosphoramidite 97% | 122194-07-4 | 5g | $293 | 2021-12-16 | Buy |
| Apolloscientific | OR963457 | Dimethyl N,N-diisopropylphosphoramidite 97% | 122194-07-4 | 5g | $363 | 2021-12-16 | Buy |
| AK Scientific | Z8605 | Dimethyl N,N-diisopropylphosphoramidite | 122194-07-4 | 10g | $549 | 2021-12-16 | Buy |
DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE Chemical Properties,Uses,Production
Uses
A useful reagent for the efficient phosphorylation of alcohols.
reaction suitability
reaction type: Phosphorylations
Synthesis
67-56-1
921-26-6
122194-07-4
General procedure for the synthesis of dimethyl N,N-diisopropylphosphoramidite amide from methanol and dichloro-N,N-diisopropylphosphoramidite: firstly, the yellow solution obtained from the reaction was subjected to rotary evaporation, followed by the direct addition of 47 mL (325 mmol, 32.9 g) of triethylamine and 250 mL of tetrahydrofuran, and stirring of the mixture to obtain a yellow suspension. Anhydrous methanol 13 mL (322 mmol, 10.3 g) was prepared in a dropping funnel, and methanol was slowly added dropwise to the reaction system over a period of 20 min under nitrogen protection and an ice-salt bath, and the dropping funnel was washed with 150 mL of tetrahydrofuran. Upon completion of the dropwise addition, the reaction mixture was transformed into a white suspension. The ice bath was removed and stirring was continued for 2 h. The reaction was then allowed to stand for a few minutes and diafiltration was performed to obtain a yellow liquid containing a light pink solid. The solid was washed with a small amount of tetrahydrofuran. The tetrahydrofuran was removed by rotary evaporation. The product was dissolved in 10 mL of 5% sodium bicarbonate solution and extracted three times with 20 mL of dichloromethane, the organic phases were combined, the dichloromethane was removed by rotary evaporation, and finally a reduced pressure distillation was performed to collect 78 stable fractions. A colorless liquid and a white solid were observed in the condenser tube, which were identified as the same substance, and the collections could be combined to give a final yield of 16.68 g with 42% yield.
References
[1] Journal of the Chemical Society. Perkin Transactions 2, 1998, # 7, p. 1621 - 1628
[2] Patent: CN102977145, 2017, B. Location in patent: Paragraph 0184; 0185
DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE Preparation Products And Raw materials
Raw materials
Preparation Products
DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11780 | 60 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18209 | 56 |
| Shenzhen Nexconn Pharmatechs Ltd. | 0755-89396905 | admin@nexconn.com | China | 299 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9955 | 58 |
View Lastest Price from DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-25 | DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE
122194-07-4
|
US $0.01 / KG | 1KG | 95%-99% | 1kg; 100kg； 500kg | Career Henan Chemical Co |
-
- DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE
122194-07-4
- US $0.01 / KG
- 95%-99%
- Career Henan Chemical Co
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