OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
- CAS No.
- 88546-55-8
- Chemical Name:
- OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
- Synonyms
- OMEPRAZOLE SULPHONE;OMeprazole Related CoMpound A;5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole;H168/66;Amlodipine Impurity F;Esomeprazole USP RC A;EsoMeprazol iMpurity D;EsoMeprazole iMpurity D;OMeprazole EP IMpurity D;(OMEPRAZOLE SULFONE) (AS)
- CBNumber:
- CB8505783
- Molecular Formula:
- C17H19N3O4S
- Molecular Weight:
- 361.42
- MDL Number:
- MFCD00869772
- MOL File:
- 88546-55-8.mol
- MSDS File:
- SDS
Melting point | 80-82°C |
---|---|
Boiling point | 599.3±60.0 °C(Predicted) |
Density | 1.331±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | ≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O |
form | Solid |
pka | 7.97±0.10(Predicted) |
color | White to off-white |
BRN | 8347309 |
FDA UNII | 76X040Z74O |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 2 | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 94319 | Omeprazole sulfone analytical standard | 88546-55-8 | 5mg | $408 | 2024-03-01 | Buy |
Sigma-Aldrich | 1478516 | Omeprazole Related Compound A United States Pharmacopeia (USP) Reference Standard | 88546-55-8 | 15mg | $1380 | 2024-03-01 | Buy |
Cayman Chemical | 18882 | Omeprazole sulfone ≥98% | 88546-55-8 | 5mg | $86 | 2024-03-01 | Buy |
Cayman Chemical | 18882 | Omeprazole sulfone ≥98% | 88546-55-8 | 10mg | $161 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR1648 | Omeprazole Sulfone Pharmaceutical Secondary Standard; Certified Reference Material | 88546-55-8 | 30mg | $711 | 2024-03-01 | Buy |
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties,Uses,Production
Description
Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).
Chemical Properties
Light Yellow Solid
Uses
A metabolite of Omeprazole.
Definition
ChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.
in vitro
omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivo
three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
References
[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
View Lastest Price from OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Omeprazole Impurity D
88546-55-8
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2019-07-06 | OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
88546-55-8
|
US $1.00 / KG | 1KG | 99% | 1000KG | Career Henan Chemical Co |
- Omeprazole Impurity D
88546-55-8
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
88546-55-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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