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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

CAS No.: 88546-55-8

Chemical Name:: OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

Synonyms: OMEPRAZOLE SULPHONE;OMeprazole Related CoMpound A;5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole;H168/66;Amlodipine Impurity F;Esomeprazole USP RC A;EsoMeprazol iMpurity D;EsoMeprazole iMpurity D;OMeprazole EP IMpurity D;(OMEPRAZOLE SULFONE) (AS)

CBNumber:: CB8505783

Molecular Formula:: C17H19N3O4S

Molecular Weight:: 361.42

MDL Number:: MFCD00869772

MOL File:: 88546-55-8.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:33

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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Properties

Melting point	80-82°C
Boiling point	599.3±60.0 °C(Predicted)
Density	1.331±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
pka	7.97±0.10(Predicted)
BRN	8347309
FDA UNII	76X040Z74O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29333990

NFPA 704

	0
2		0

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	94319	Omeprazole sulfone analytical standard	88546-55-8	5mg	$408	2024-03-01	Buy
Sigma-Aldrich	1478516	Omeprazole Related Compound A United States Pharmacopeia (USP) Reference Standard	88546-55-8	15mg	$1380	2024-03-01	Buy
Cayman Chemical	18882	Omeprazole sulfone ≥98%	88546-55-8	5mg	$86	2024-03-01	Buy
Cayman Chemical	18882	Omeprazole sulfone ≥98%	88546-55-8	10mg	$161	2024-03-01	Buy
Sigma-Aldrich	PHR1648	Omeprazole Sulfone Pharmaceutical Secondary Standard; Certified Reference Material	88546-55-8	30mg	$711	2024-03-01	Buy

Product number	Packaging	Price	Buy
94319	5mg	$408	Buy
1478516	15mg	$1380	Buy
18882	5mg	$86	Buy
18882	10mg	$161	Buy
PHR1648	30mg	$711	Buy

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties,Uses,Production

Description

Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC₅₀ = 18 μM).

Chemical Properties

Light Yellow Solid

Uses

A metabolite of Omeprazole.

Definition

ChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.

in vitro

omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].

in vivo

three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].

References

[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials

Raw materials

Preparation Products

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Suppliers

Global( 201)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9635	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Finetech Industry Limited	58

View Lastest Price from OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) 88546-55-8	US $1.00 / KG	1KG	99%	1000KG	Career Henan Chemical Co

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
88546-55-8
US $1.00 / KG
99%
Career Henan Chemical Co

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Spectrum

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)(88546-55-8)¹HNMR

88546-55-8(OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS))Related Search:

5-METHOXY-2-[(3,5-DIMETHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE 8-Methoxy-1,3-dimethyl-12-thioxo-pyrido[123,4]imidazo[1,2-a]benzimidazol-2-(12H)-one 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE 4-Hydroxy Omeprazole Sulfide 2-[[(3,5-DiMethyl-2-pyridinyl)Methyl]thio]-6-Methoxy-1H-benziMidazole

Ufiprazole (S)-4-Desmethoxy-4-chloro Omeprazole Omeprazole Ondansetron EP Impurity H ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate

4-Hydroxy Omeprazole omeprazole acid 2-[(5-CARBOXY-4-METHOXY-3-METHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Omeprazole EP Impurity G

Omeprazole Sulfone N-Oxide OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) MM STANDARD Omeprazole Impurity (2-[[(5-hydroxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-3,5-dimethy-l-4(1H)-pyridone) Omeprazole Related Compound A

1of4

EsoMeprazol iMpurity D OMeprazole IMpurity-D(EP) (USP R C A) 6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole OMeprazole EP IMpurity D 5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole 5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole (RelCpd D) 1H-BenziMidazole, 6-Methoxy -2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfonyl]- EsoMeprazole iMpurity D Esomeprazole Magnesium Trihydrate Imp. D (EP): 5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole (Omeprazole Sulphone) Amlodipine Impurity F Omeprazole metabolite Omeprazole sulfone Omeprazole Related Compound A (15 mg) (5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfonyl]-1H-benzimidazole) Esomeprazole EP Impurity D Esomeprazole Impurity D H168/66 Esomeprazole Magnesium Trihydrate EP D OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) OMEPRAZOLE IMP. A (EP):5-METHOXY-1H-BENZIMIDAZOLE-2-THIOL MM STANDARD 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazol 6-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole OMeprazole Related CoMpound A (AS) 6-Methoxy-2-{[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl}-1H-benziMidazole Omeprazole Related Compound A (15 mg) (Omeprazole Sulfone or 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole) (OMEPRAZOLE SULFONE) (AS) EsoMeprazole related substance D H168/66 5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole(oMeprazole-sulfone) -Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole(oMeprazole-sulfone) IMp. D (EP): 5-Methoxy-2-[[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]sulphonyl]-1H- benziMidazole (OMeprazole Sulphone) Esomeprazole sodium D(H168/66) Esomeprazole Sodium?CP Impurity Ⅰ 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfonyl]benzimidazole USP Omeprazole Related Compound A Omeprazole Sulfone USP Omeprazole Related Compound A Omeprazole EP Impurity D (Omeprazole Sulfone) Esomeprazole EP Impurity D(Omeprazole EP Impurity D) Esomeprazole impurity 1/Esomeprazole EP Impurity D/Omeprazole EP Impurity D/Omeprazole Sulfone/5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole Omeprazole impurity 4/Omeprazole EP Impurity D/Omeprazole Sulfone/5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole Omeprazole EP Impurity D：Omeprazole Impurity D Omeprazole impurity D CRS Omeprazole EP Impurity D (Esomeprazole Impurity D) Omeprazole Related Compound A (15 mg) omeprazole Imp-D (sulfoxide) Omeprazole Impurity D(Sulfoxide) Esomeprazole EP Impurity D/Esomeprazole RC A/Omeprazole EP Impurity D /Omeprazole Sulfone Esomeprazole EP Impurity D/ Esomeprazole Related Compound A (Omeprazole EP Impurity D/ Omeprazole Sulfone) Omeprazole EP Impurity D (Omeprazole Sulfone/ Esomeprazole EP Impurity D/ Esomeprazole Related Compound A) 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sul... Esomeprazole Impurities544 Esomeprazole EP Impuritie D Omeprazole impurity DQ: What is Omeprazole impurity D Q: What is the CAS Number of Omeprazole impurity D Q: What is the storage condition of Omeprazole impurity D Q: What are the applications of Omeprazole impurity D Omeprazole Related Compound A (5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfonyl]-1 (1478516) OMeprazole Related CoMpound A 5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole OMEPRAZOLE SULPHONE Omeprazole Impurity D（EP) Esomeprazole Sodium EP Impurity D Omeprazole USP Related Compound A