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PHYSOSTIGMINE

PHYSOSTIGMINE
PHYSOSTIGMINE
CAS No.
57-47-6
Chemical Name:
PHYSOSTIGMINE
Synonyms
Ezerin;cs58525;mcv4484;Cogmine;ESERINE;Erserine;CS 58525;Synapton;nih10421;NSC 30782
CBNumber:
CB8770121
Molecular Formula:
C15H21N3O2
Formula Weight:
275.35
MOL File:
57-47-6.mol

PHYSOSTIGMINE Properties

Melting point:
102-104 °C(lit.)
alpha 
D17 -76° (c = 1.3 in chloroform); D25 -120° (benzene)
Boiling point:
418.29°C (rough estimate)
Density 
1.166±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5600 (estimate)
Flash point:
>100℃
storage temp. 
2-8°C
form 
Powder
pka
6.12, 12.24(at 25℃)
color 
Off-white
Water Solubility 
Soluble in water (1:75), alcohol (1:10), chloroform (1:1), ether (1:30), and DMSO.
Sensitive 
Air & Light Sensitive
Merck 
7384
CAS DataBase Reference
57-47-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+
Risk Statements  26/28
Safety Statements  23-45-25
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  TJ2100000
8-10
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 orally in mice: 4.5 mg/kg (Lynch, Coon)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P284 Wear respiratory protection.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

PHYSOSTIGMINE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J61477 Eserine 57-47-6 100mg $31.8 2018-11-13 Buy
Cayman Chemical 13027 Physostigmine ≥98% 57-47-6 50mg $18 2018-11-19 Buy
Cayman Chemical 13027 Physostigmine ≥98% 57-47-6 100mg $31 2018-11-19 Buy
Cayman Chemical 13027 Physostigmine ≥98% 57-47-6 250mg $72 2018-11-19 Buy
Cayman Chemical 13027 Physostigmine ≥98% 57-47-6 500mg $135 2018-11-19 Buy

PHYSOSTIGMINE Chemical Properties,Uses,Production

Chemical Properties

Physostigmine is a white crystalline solid. Odorless.

Uses

Physostigmine base (Eserine-Base) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Uses

It is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying.

brand name

Eserine Sulfate (Ciba Vision, US Ophthalmics).

General Description

White, odorless, microcrystalline powder. Used as a cholinergic (anticholinesterase) agent and as a veterinary medication.

Health Hazard

Super toxic. Probable oral lethal dose is less than 5 mg/kg for a 70 kg (150 lb.) person. Material is a cholinesterase inhibitor. Effects of exposure may involve the respiratory, gastrointestinal, cardiovascular and central nervous systems. Death occurs due to respiratory paralysis or impaired cardiac function. Time to death may vary from 5 minutes to 24 hours, in severely poisoned patients, depending on factors such as the dose and route. Persons with asthma and/or persons that require drugs containing choline esters are at risk.

Fire Hazard

PHYSOSTIGMINE is a slight fire hazard. When heated to decomposition PHYSOSTIGMINE emits toxic fumes of nitrogen oxides. Keep from light and heat.

Safety Profile

A human poison by an unspecified route. Poison experimentally by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: nausea, dyspnea, coma, blood pressure elevation, flaccid paralysis without anesthesia, muscle weakness. Normally administered by injection. Poisoning can occur as a result of a mistake in dosage or due to hypersensitivity of the patient withm 5 to 25 minutes after administration. Death usually results from respiratory paralysis. Experimental reproductive effects. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.

Potential Exposure

Physostigmine, an alkaloid, originally derived from the calabar bean (Physostigma venenosum) isa potent and reversible inhibitor of cholinesterase. Material is used as a cholinergic (anticholinesterase) agent and as a veterinary medication. Although listed as a carbamate pesticide, physostigmine is not registered for use as an agricultural chemical in the United States.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Eserine crystallises from Et2O or *C6H6 and forms an unstable low melting form m 86-87o [Harley-Mason & Jackson J Chem Soc 3651 1954, Wijnberg & Speckamp Tetrahedron 34 2399 1978]. [Beilstein 23/11 V 401.]

Incompatibilities

Light and heat.

Waste Disposal

It is not appropriate to dispose of expired or waste drugs or waste product such as lab chemicals by flushing them down the toilet or discarding them to the trash. Larger quantities shall carefully take into consideration applicable EPA, and FDA regulations. If possible return the lab chemicals to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste lab chemicals shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

PHYSOSTIGMINE Preparation Products And Raw materials

Raw materials

Preparation Products


PHYSOSTIGMINE Suppliers

Global( 80)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
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Chembest Research Laboratories Limited +86(0)21-20908456
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Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32520 50
BEST-REAGENT 028-85973071 028-85973075
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Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
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PHYSOSTIGMINE Spectrum


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