5-bromobenzo[d]isoxazol-3-one
![5-bromobenzo[d]isoxazol-3-one Structure](CAS/GIF/65685-50-9.gif)
- CAS No.
- 65685-50-9
- Chemical Name:
- 5-bromobenzo[d]isoxazol-3-one
- Synonyms
- 5-broMo-1,2-benzoxazol-3-ol;5-bromo-1,2-benzoxazol-3-one;5-Bromobenzisoxazol-3(2H)-one;5-bromobenzo[d]isoxazol-3-one;5-Bromobenzo[d]isoxazol-3(2H);5-BroMobenzo[d]isoxazol-3(2H)-one;1,2-Benzisoxazol-3(2H)-one, 5-bromo-;5-bromo-2,3-dihydro-1,2-benzoxazol-3-one
- CBNumber:
- CB91509086
- Molecular Formula:
- C7H4BrNO2
- Molecular Weight:
- 214.02
- MDL Number:
- MFCD01658969
- MOL File:
- 65685-50-9.mol
- MSDS File:
- SDS
5-bromobenzo[d]isoxazol-3-one price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB141713 | 5-Bromobenzo[d]isoxazol-3(2H)-one | 65685-50-9 | 50mg | $82 | 2021-12-16 | Buy |
| AK Scientific | Z5002 | 5-Bromobenzo[d]isoxazol-3(2H)-one | 65685-50-9 | 25mg | $99 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB141713 | 5-Bromobenzo[d]isoxazol-3(2H)-one | 65685-50-9 | 100mg | $142 | 2021-12-16 | Buy |
| AK Scientific | J96303 | 5-Bromobenzo[d]isoxazol-3(2H)-one | 65685-50-9 | 100mg | $203 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB141713 | 5-Bromobenzo[d]isoxazol-3(2H)-one | 65685-50-9 | 250mg | $282.5 | 2021-12-16 | Buy |
5-bromobenzo[d]isoxazol-3-one Chemical Properties,Uses,Production
Synthesis
5798-94-7
![5-bromobenzo[d]isoxazol-3-one](/CAS/GIF/65685-50-9.gif)
65685-50-9
The general procedure for the synthesis of 5-bromobenzo[d]isoxazol-3(2H)-one from the compound (CAS:5798-94-7) was as follows: thionyl chloride (10 ml) was added slowly and dropwise to a solution of δ-bromosalicylcarbamic acid F2 (21.6 g) in tetrahydrofuran (60 ml) under stirring conditions at 10-200 °C. Stirring of the reaction mixture was continued for 2 hours by maintaining the same temperature. Subsequently, the reaction mixture was evaporated under reduced pressure to remove the solvent, the residue was dissolved in dioxane (60 ml) and the solution was cooled to 0-50 °C. To this cooled reaction mixture triethylamine (38 ml) was added and stirred at 37 °C. After that, the reaction mixture was allowed to stand at room temperature for 1 hour. The solvent was again removed by evaporation under reduced pressure and ice water (300 mL) was added to the residue. The pH of the mixture was adjusted to 2 using concentrated hydrochloric acid, at which point crystals were precipitated, and the precipitated crystals were collected by filtration and washed with water. Finally, the target compound F3 was purified by recrystallization from ethyl acetate to give the target compound F3 (17.5 g, 88% yield) as colorless needle-like crystals.
References
[1] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 75; 76
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3357 - 3359
[3] Patent: US2015/175560, 2015, A1. Location in patent: Paragraph 0468; 0470
5-bromobenzo[d]isoxazol-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
5-bromobenzo[d]isoxazol-3-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Synthfine Chemical Co.,Ltd | 15921303235 | sales@synthfine.com | China | 987 | 58 |
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 1005 | 59 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| Shanghai Xingui Biotechnology Co., Ltd. | 18117142316 | xingui2022@126.com | China | 9952 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 18019252918 | sale@amkchem.com | China | 15297 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 12346 | 58 |