ChemicalBook >> CAS DataBase List >>(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
- CAS No.
- 17257-71-5
- Chemical Name:
- (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
- Synonyms
- (-)-MTPA;(S)-(-)-MPTA;MOSHERS ACID;(-)-MOSHER'S ACID;(S)-(-)-Mosheracid;(S)-(-)-MOSHER'S ACID;(-)-MTPA, Moshers acid;(-)-Moshers acid~(-)-MTPA;(S)-(-)-MTPA,(S)-(-)-Mosher'sacid;(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
- CBNumber:
- CB9171585
- Molecular Formula:
- C10H9F3O3
- Molecular Weight:
- 234.17
- MDL Number:
- MFCD00064200
- MOL File:
- 17257-71-5.mol
- MSDS File:
- SDS
Last updated:2023-04-23 13:52:06
| Melting point | 46-49 °C(lit.) |
|---|---|
| alpha | D24 -71.8± 0.6° (c = 3.28 in CH3OH) |
| Boiling point | 95-97 °C0.05 mm Hg(lit.) |
| Density | 1.303 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Readily soluble in hexane, ether, THF, CH2Cl2, benzene. |
| pka | 1.47±0.10(Predicted) |
| form | Viscous Liquid or Low Melting Solid |
| Specific Gravity | 1.303 |
| color | Clear colorless or white |
| optical activity | [α]20/D 73±1°, c = 2% in methanol |
| Sensitive | Hygroscopic |
| Merck | 14,6280 |
| BRN | 3591561 |
| CAS DataBase Reference | 17257-71-5(CAS DataBase Reference) |
| FDA UNII | 172HCJ1IQV |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT, HYGROSCOPIC, KEEP COLD | |||||||||
| HS Code | 29189900 | |||||||||
| NFPA 704 |
|
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 318035 | (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% | 17257-71-5 | 250mg | $80.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 318035 | (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% | 17257-71-5 | 1g | $170 | 2024-03-01 | Buy |
| Sigma-Aldrich | 65369 | (S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, LiChropur?, ≥99.0% | 17257-71-5 | 250mg | $162 | 2022-05-15 | Buy |
| TCI Chemical | M0832 | (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) | 17257-71-5 | 1g | $187 | 2024-03-01 | Buy |
| TCI Chemical | M0832 | (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) | 17257-71-5 | 5g | $693 | 2024-03-01 | Buy |
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
clear colorless viscous liquid
Uses
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.
General Description
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.
Purification Methods
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Suppliers
Global( 142)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99%
17257-71-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99%
17257-71-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Spectrum
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)1HNMR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)IR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)FT-IR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)Raman
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1of4
(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
(S)-(-)-MOSHER'S ACID
(S)-(-)-MPTA
(S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(S)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(-)-MOSHER'S ACID
MOSHERS ACID
(-)-MTPA
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
(-)-Moshers acid~(-)-MTPA
(S)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
(-)-MTPA, Moshers acid
(S)-(-)-Mosheracid
(S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid
[S,(-)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid
[S,(-)]-α-Trifluoromethyl-α-methoxyphenylacetic acid
[S,(-)]-β,β,β-Trifluoro-α-methoxyhydratropic acid
(S)-()-α-Methoxy-α-trifluoromethylphenylacetic acid,()-MTPA, Mosher’s acid
(2S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99% (99%ee)
(S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid
(S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic Acid
(S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid, 98% 250MG
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid,98%
(S)-(-)-α-Methoxy-α-(trifluoroMethyl)phenylacetic Acid [Optical Resolving]
(S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid >=99%
(2S)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99%
minus-A-methoxy-A-trifluoro-methyl*phenylacetic A
(S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL) PH ENYLACETIC ACID, 99+% (99% EE/GLC)
MINUS-A-METHOXY-A-TRIFLUORO-METHYL*PHENY LACETIC ACI
(S)-(-)-A-METHOXY-A-(TRIFLUORO-ME-)-PH-A CETIC ACID, CHIRASELECT REAG (99+%EE)
(S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee)
(S)-(-)-MTPA,(S)-(-)-Mosher'sacid
Benzeneacetic acid, .alpha.-methoxy-.alpha.-(trifluoromethyl)-, (.alpha.S)-
(s)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetic acid
(S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)
(S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)
(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
(2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylaceticAcid[OpticalResolving]>
Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αS)-
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic ac
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
(2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
17257-71-5
Asymmetric Synthesis
Derivatization Reagents
Chiral Resolving Reagents
Chiral Resolution Reagents
Analytical Chromatography Product Catalog
Chiral Derivatization
e.e. / Absolute Conefiguration Determination (NMR)
Enantiomer Excess & Absolute Conefiguration Determination
Analytical Chemistry