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Val-cit-PAB-OH

Val-cit-PAB-OH structure

CAS No.: 159857-79-1

Chemical Name:: Val-cit-PAB-OH

Synonyms: H-Val-Cit-PAB-OH;(S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide;EOS-61316;al-Cit-PAB-OH;H-Val-Cit-PAB;Val-cit-PAB-OH;(D)-VAL-CIT-PAB;NH2-Val-Cit-PAB;2-(4-(((2,6-dimethylbenzoyl)oxy)methyl)phenyl)aceticacid;L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

CBNumber:: CB92715206

Molecular Formula:: C18H29N5O4

Molecular Weight:: 379.45

MDL Number:: MFCD22381209

MOL File:: 159857-79-1.mol

Last updated:2024-03-29 16:09:00

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Val-cit-PAB-OH Properties

Melting point	168 °C(dec.)
Boiling point	715.0±60.0 °C(Predicted)
Density	1.243±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
form	powder to crystal
pka	13.75±0.46(Predicted)
color	White to Almost white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H319-H302

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

HS Code

2924.29.7790

NFPA 704

	0
2		0

Val-cit-PAB-OH price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	V0155	Val-Cit-PAB-OH	159857-79-1	25MG	$160	2024-03-01	Buy
TCI Chemical	V0155	Val-Cit-PAB-OH	159857-79-1	100MG	$482	2024-03-01	Buy
TRC	V091545	Val-cit-PAB-OH	159857-79-1	100mg	$580	2021-12-16	Buy
BroadPharm	BP-23218	Val-Cit-PAB-OH 95%	159857-79-1	500mg	$290	2021-12-16	Buy
ChemScene	CS-5171	Val-cit-PAB-OH 99.35%	159857-79-1	250mg	$157	2021-12-16	Buy

Product number	Packaging	Price	Buy
V0155	25MG	$160	Buy
V0155	100MG	$482	Buy
V091545	100mg	$580	Buy
BP-23218	500mg	$290	Buy
CS-5171	250mg	$157	Buy

Val-cit-PAB-OH Chemical Properties,Uses,Production

Description

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.

Uses

Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.

Val-cit-PAB-OH synthesis

Synthesis of Val-cit-PAB-OH from FMoc-Val-Cit-PAB

Val-cit-PAB-OH Preparation Products And Raw materials

Raw materials

L-Ornithinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- H-Cit-PABA Boc-Val-Cit-PABA FMOC-L-Valine L-Citrulline

Fmoc-Val-Cit-OH FMOC-VAL-OPFP FMoc-Val-Cit-PAB FMOC-VAL-OSU Fmoc-Cit-PABA

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Preparation Products

MC-Val-Cit-PAB L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-

Val-cit-PAB-OH Suppliers

Global( 199)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12550	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58
TargetMol Chemicals Inc.	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from Val-cit-PAB-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-29	Val-Cit-PAB-OH 159857-79-1	US $0.00 / g	5g	>95.00%	5g	Xian confluore Biological Technology Co., Ltd.
2022-10-14	Val-cit-PAB-OH 159857-79-1	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-03-06	Val-cit-PAB-OH 159857-79-1	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

Val-Cit-PAB-OH
159857-79-1
US $0.00 / g
>95.00%
Xian confluore Biological Technology Co., Ltd.

Val-cit-PAB-OH
159857-79-1
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Val-cit-PAB-OH
159857-79-1
US $1.00 / g
≥98%
Career Henan Chemical Co

159857-79-1(Val-cit-PAB-OH)Related Search:

Peptide synthesis ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE Peptide impurity peptide CRO OGP (Ostegenic Growth Peptide)

Peptide phosphorylation marker Peptide fluorescent modification GMP peptide CMO L-Threonine, L-asparaginyl-L-alanyl-L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-arginylglycyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-L-valyl-L-alanyl-L-arginyl- FMoc-Val-Cit-PAB-PNP

pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH FMoc-Val-Cit-PAB MC-Val-Cit-PAB

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(S)-2-((R)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide Val-cit-PAB-OH L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide EOS-61316 L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- NH2-Val-Cit-PAB (D)-VAL-CIT-PAB al-Cit-PAB-OH (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide H-Val-Cit-PAB-OH 2-(4-(((2,6-dimethylbenzoyl)oxy)methyl)phenyl)aceticacid H-Val-Cit-PAB (2S)-2-[[(2S)-2-amino-3-methyl-butanoyl]amino]-N-[4-(hydroxymethyl)phenyl]-5-ureido-pentanamide 159857-79-1 Linker ADC LINKER ADCs ADC-Linkers