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2,3-Naphthalenedicarboxylic Anhydride

2,3-Naphthalenedicarboxylic Anhydride structure

CAS No.: 716-39-2

Chemical Name:: 2,3-Naphthalenedicarboxylic Anhydride

Synonyms: EA253;2,3-NAPHTHALI;2,3-NAPHTHALIC ANHYDRIDE;naphtho[2,3-c]furan-1,3-dione;benzo[f][2]benzofuran-1,3-dione;benzo[f]isobenzofuran-1,3-quinone;2,3-Napthalenedicarboxycanhydride;2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE;2,3-NaphthalenedicarboxylicAnhydride>1,3-Dihydronaphtho[2,3-c]furan-1,3-dione

CBNumber:: CB9286597

Molecular Formula:: C12H6O3

Molecular Weight:: 198.17

MDL Number:: MFCD00059091

MOL File:: 716-39-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:07

Product description	Number	Pack Size	Price
2,3-NAPHTHALIC ANHYDRIDE Aldrich^CPR	S876682	1 unit	$121
2,3-NAPHTHALIC ANHYDRIDE Aldrich	S876682	50mg	$110
2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T)	N0530	25g	$182
2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T)	N0530	250g	$733
2,3-NAPHTHALIC ANHYDRIDE	N363000	5g	$100
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2,3-Naphthalenedicarboxylic Anhydride Properties

Melting point	246 °C
Boiling point	275-280 °C(Press: 100 Torr)
Density	1.449±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	Pale Beige
Stability	Moisture Sensitive
InChI	InChI=1S/C12H6O3/c13-11-9-5-7-3-1-2-4-8(7)6-10(9)12(14)15-11/h1-6H
InChIKey	IZJDCINIYIMFGX-UHFFFAOYSA-N
SMILES	O1C(=O)C2=CC3C(C=C2C1=O)=CC=CC=3
EPA Substance Registry System	Naphtho[2,3-c]furan-1,3-dione (716-39-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Safety Statements	22-24/25
TSCA	TSCA listed
HS Code	2917.39.7000

2,3-Naphthalenedicarboxylic Anhydride price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S876682	2,3-NAPHTHALIC ANHYDRIDE Aldrich^CPR	716-39-2	1 unit	$121	2026-03-19	Buy
Sigma-Aldrich	S876682	2,3-NAPHTHALIC ANHYDRIDE Aldrich	716-39-2	50mg	$110	2024-03-01	Buy
TCI Chemical	N0530	2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T)	716-39-2	25g	$182	2026-03-19	Buy
TCI Chemical	N0530	2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T)	716-39-2	250g	$733	2026-03-19	Buy
TRC	N363000	2,3-NAPHTHALIC ANHYDRIDE	716-39-2	5g	$100	2021-12-16	Buy

Product number	Packaging	Price	Buy
S876682	1 unit	$121	Buy
S876682	50mg	$110	Buy
N0530	25g	$182	Buy
N0530	250g	$733	Buy
N363000	5g	$100	Buy

2,3-Naphthalenedicarboxylic Anhydride Chemical Properties,Uses,Production

Appearance

2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE is a pale Beige Solid.

Description

A few years ago, the product was still synthesized from the corresponding diacid, but in recent years, it has been difficult to find the shadow of the diacid in the market, and the sales of this product have been repeatedly restricted, resulting in high prices.

Uses

2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.

Preparation

Add anhydrous tetrahydrofuran (its mass ratio to maleic anhydride is 1.5:1), cat-1 (0.05 mole), maleic anhydride (1 mole), and o-phthalaldehyde (1.5 mole) to the reactor. After adding triethylamine (5 moles), adjust the temperature below -40°C. Silicon tetrachloride (4 moles) was added dropwise to the reaction system and the reaction was placed at -40 °C for 4 h. The mixture was heated to reflux for 20 h. After the end of the reaction, concentrating the solution to a certain concentration with diatomaceous earth filtration. A light yellow solid, namely 2,3-Naphthalenedicarboxylic Anhydride, is obtained by precipitation, filtration, recrystallization and drying. Its yield reaches 88%.

Synthesis

7193-16-0

716-39-2

In a 5 mL sealed tube, tert-butyl peroxybenzoate (TBPB, 30 mol%, 0.041 g) and 70 wt% aqueous tert-butyl hydroperoxide (TBHP, 1.0 mmol, 0.131 g) were added to a solution of benzyl alcohol 1a (0.4 mmol, 0.043 g) dissolved in chlorobenzene (1 mL). The reaction mixture was heated at 80°C for 2.5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature and saturated sodium bicarbonate solution (2 mL) was added. The reaction product was extracted with ethyl acetate (2 x 3 mL). The organic phases were combined and dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure. The residue was purified by column chromatography using hexane-ethyl acetate (15:1, v/v) as eluent to afford pure 2,3-naphthalenedicarboxylic anhydride (2a) as a white solid.

References

[1] Synlett, 2018, vol. 29, # 1, p. 136 - 140

2,3-Naphthalenedicarboxylic Anhydride synthesis

Synthesis of 2,3-Naphthalenedicarboxylic Anhydride from 4,9-Epoxybenz[f]isobenzofuran-1,3-dione, 3a,4,9,9a-tetrahydro-

2,3-Naphthalenedicarboxylic Anhydride Preparation Products And Raw materials

Raw materials

Naphtho[2,3-c]furan, 1,3-dihydro- 4,9-Epoxybenz[f]isobenzofuran-1,3-dione, 3a,4,9,9a-tetrahydro- 7,12-Dihydrobenz[a]anthracene 2-Naphthalenecarboxaldehyde, 3-(2-formylphenyl)- Isobenzofuran, 1-ethoxy-1,3-dihydro-

ALPHA,ALPHA,ALPHA',ALPHA'-TETRABROMO-O-XYLENE 2,3-Naphthalenedicarboxylic acid Benz[a]anthracene o-Phthalaldehyde Thionyl chloride

Maleic anhydride

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Preparation Products

1H-Benz[f]isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- 3-BENZOYL-2-NAPHTHOIC ACID

2,3-Naphthalenedicarboxylic Anhydride Suppliers

Global( 169)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou uniringchem Co., Ltd.	+undefined13585446801	sales@uniringchem.com	China	69	58
Sirichem (Zhangjiakou) Sci-Tech.Co.,Ltd.	+8615831567206		China	58	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58

Supplier	Advantage
Changzhou uniringchem Co., Ltd.	58
Sirichem (Zhangjiakou) Sci-Tech.Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from 2,3-Naphthalenedicarboxylic Anhydride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE 716-39-2	US $1.10 / g	1g	99.00%	100 Tons	Dideu Industries Group Limited
	2019-07-06	2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE 716-39-2	US $2.00 / kg	1kg	99%	ask	Career Henan Chemical Co

2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE
716-39-2
US $1.10 / g
99.00%
Dideu Industries Group Limited

2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE
716-39-2
US $2.00 / kg
99%
Career Henan Chemical Co

2,3-Naphthalenedicarboxylic Anhydride Spectrum

2,3-Naphthalenedicarboxylic Anhydride(716-39-2)¹HNMR

716-39-2(2,3-Naphthalenedicarboxylic Anhydride)Related Search:

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2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE 1,3-Dihydronaphtho[2,3-c]furan-1,3-dione benzo[f][2]benzofuran-1,3-dione benzo[f]isobenzofuran-1,3-quinone 2,3,NAPHTHALENEDICARBOXYLIC ACIDANHYDRIDE naphtho[2,3-c]furan-1,3-dione 2,3-NAPHTHALIC ANHYDRIDE 2,3-NAPHTHALI 2,3-NaphthalenedicarboxylicAnhydride> 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE ISO 9001：2015 REACH EA253 2,3-Napthalenedicarboxycanhydride 716-39-2 Exciton Chirality CD Method (for Primary Amino Groups) Enantiomer Excess & Absolute Conefiguration Determination Absolute Conefiguration Determination (Exciton Chirality CD Method) Absolute Configuration Determination (Exciton Chirality CD Method) Analytical Chemistry Enantiomer Excess & Absolute Configuration Determination Exciton Chirality CD Method (for Primary Amino Groups)