ChemicalBook
Chinese Japanese Germany Korea

o-Phthalaldehyde

o-Phthalaldehyde
o-Phthalaldehyde structure
CAS No.
643-79-8
Chemical Name:
o-Phthalaldehyde
Synonyms
OPA;OPD;o-PhthaL;Phtharal;CIDEX-OPA;phthaldehyde;PHTHALALDEHYDE;2-PHTHALDEHYDE;Phthaldialdehy;phtalaldehydes
CBNumber:
CB6731197
Molecular Formula:
C8H6O2
Formula Weight:
134.13
MOL File:
643-79-8.mol

o-Phthalaldehyde Properties

Melting point:
55-58 °C(lit.)
Boiling point:
83-84 °C (0.7501 mmHg)
Density 
1.13
refractive index 
1.4500 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
The solubility of o-phthalaldehyde is 3g/100 mL diisopropyl ether, 5g/100mL deionized water, 20g/100mL chloroform, or 20g/100mL acetone at 20°C.
form 
powder
color 
yellow
PH
7 (53g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,7368
BRN 
878317
Stability:
Stable. Air sensitive. Incompatible with strong oxidizing agents, strong bases.
InChIKey
ZWLUXSQADUDCSB-UHFFFAOYSA-N
CAS DataBase Reference
643-79-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
4P8QP9768A
NIST Chemistry Reference
O-phthalaldehyde(643-79-8)
EPA Substance Registry System
1,2-Benzenedicarboxaldehyde (643-79-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS09,GHS06
Signal word  Danger
Hazard statements  H300-H318-H301-H314-H317-H400-H411-H410
Precautionary statements  P273-P280-P301+P310-P305+P351+P338-P310-P303+P361+P353-P304+P340+P310-P391-P260-P260h-P301+P310a-P405-P501a
Hazard Codes  Xi,T,N,C
Risk Statements  36/37/38-43-34-25-50-52/53
Safety Statements  26-28-36-45-36/37/39-61-37/39
RIDADR  UN2923 8/PG 2
WGK Germany  3
RTECS  TH6950000
1-8-10
Autoignition Temperature 480 °C
Hazard Note  Irritant/Air Sensitive
TSCA  Yes
HazardClass  8
PackingGroup 
HS Code  29122900
Toxicity LD50 orally in Rabbit: 178 mg/kg LD50 dermal Rat > 2000 mg/kg
NFPA 704
0
0 0

o-Phthalaldehyde price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.21027 Phthaldialdehyde for synthesis 643-79-8 500 mg $35.24 2021-03-22 Buy
Sigma-Aldrich 8.21027 Phthaldialdehyde for synthesis 643-79-8 10 g $107.3 2021-03-22 Buy
Sigma-Aldrich 79760 Phthaldialdehyde for fluorescence, ≥99.0% (HPLC) 643-79-8 1g $170 2021-03-22 Buy
Sigma-Aldrich 8.21027 Phthaldialdehyde for synthesis 643-79-8 50 g $313.57 2021-03-22 Buy
Sigma-Aldrich 79760 Phthaldialdehyde for fluorescence, ≥99.0% (HPLC) 643-79-8 5g $528 2021-03-22 Buy

o-Phthalaldehyde Chemical Properties,Uses,Production

Chemical Properties

o-Phthalaldehyde is a pale yellow crystalline solid.
o-Phthalaldehyde
o-Phthalaldehyde is mainly used as a high-level disinfectant (a low-temperature chemical method) for heat-sensitive medical and dental equipment such as endoscopes and thermometers; in recent years, it has gained popularity as a safe and better alternative to glutaraldehyde.
There are some researches show, pH7.5 contains the sterilizing agent of o-phthalaldehyde 0.5%, and its sterilizing power, sterilization speed, stability and toxicity all are better than glutaraldehyde, can kill mycobacterium in the 5min, the bacterium number reduces by 5 logarithmic value, and o-phthalaldehyde is very stable, tasteless in pH3~9 scopes, non-stimulated to human nose, eye mucosa, and need not activate before using, various materials are had good consistency, have tangible microbiocidal activity.

Uses

o-Phthalaldehyde can be widely used for precolumn derivatization of amino acids in HPLC separation or Capillary electrophoresis. For flow cytometric measurements of protein thiol groups.

Uses

o-Phthalaldehyde can be used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups.

Uses

Precolumn derivatization reagent for primary amines and amino acids. The fluorescent derivative can be detected by reverse-phase HPLC. The reaction requires OPA, primary amine and a sulfhydryl. In the presence of excess sulfhydryl, amines can be quantitated. In the presence of excess amine, sulfhydryls can be quantitated.

Uses

Disinfectant. Reagent in fluorometric determination of primary amines and thiols.

Preparation

o-Phthalaldehyde is a high-level chemical disinfectant that is commonly used for disinfection of dental and medical instruments as an alternative to glutaraldehyde, which is a known skin and respiratory sensitizer.
A variety of processes for manufacturing o-phthalaldehyde have been reported in the literature.
o-Phthalaldehyde is produced by heating pure benzaldehyde and chloroform with potassium hydroxide solution. The resulting solution is further acidified with hydrochloric acid and cooled to yield a colorless powder of o-phthalaldehyde.
It is also produced by ozonization of naphthalene in alcohol followed by catalytic hydrogenation.
Catalytic oxidation of various chemicals is also used in manufacturing o-phthalaldehyde. o-Phthalaldehyde can be manufactured by oxidation of phthalan by nitrogen monoxide in acetonitrile with N-hydroxyphthalimide as the catalyst to yield 80% to 90%.

Definition

ChEBI: A dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 1668, 1951 DOI: 10.1021/ja01148a076
Tetrahedron Letters, 27, p. 1793, 1986 DOI: 10.1016/S0040-4039(00)84377-4

Biotechnological Applications

O-phthalaldehyde(OPA) is used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups. Used for fluorometric determination of histamine, histidine and other amino acids. Also used for cholesterol assay in the picomole range.
Phthaldialdehyde has been used:
in the preparation of O-phthaldialdehyde reagent for analysing gentamycin content.
in the preparation of reagent for determining the degree of hydrolysis of milk proteins.
in the measurement of free amino acids of milk samples by O-phthaldialdehyde/N-acetyl-L-cysteine (OPA/NAC) assay.
in the derivatization of putrescine samples.

Potential Exposure

The primary routes of human exposure to o-phthalaldehyde are by inhalation and through the skin, which may occur through accidental or occupational exposures. Along with its increasing popularity as a chemical sterilizer, o-phthalaldehyde has many applications in analytical methods and in diagnostic kits. o-Phthalaldehyde is also used as an intermediate in the synthesis of pharmaceuticals and as a reagent in the tanning industry, hair colorings, wood treatment, and antifouling paints. o-Phthalaldehyde was approved for use as an indoor antimicrobial pesticide in 1997; however, it is no longer registered with the United States Environmental Protection Agency (USEPA) for this use.

Carcinogenicity

No information on the carcinogenicity of o-phthalaldehyde in experimental animals or humans was found in a review of the literature.

o-Phthalaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products


o-Phthalaldehyde Suppliers

Global( 576)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1310 58
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 cathy@hnxtchem.com CHINA 293 58
Changzhou Carman Chemical Co., Ltd.
15061933924
jane@carmanchem.com; catal@carmanchem.com CHINA 514 58
Univar Solutions(China) Co., Ltd.
15902132654
86-21-61932700 Ivy.zhuang@univarsolutions.com CHINA 275 58
Hebei Mojin Biotechnology Co., Ltd
0086 15533627333
admin@hbmojin.com CHINA 960 58
Jinan Qinmu Fine Chemical Co.,Ltd.
18660799346 18363098612
+86 531 8316 6650 sales@qinmuchem.com CHINA 1009 58
Finetech Industry Limited
86 27 87465837
86 27 87772287 info@finetechnology-ind.com CHINA 9373 58
Hebei Crovell Biotech Co Ltd
19930504644 whatsapp +8619930504644
86-0311-66562153 sales4@crovellbio.com CHINA 2826 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Springchem New Material Technology Co.,Limited
+8613917661608 +86-021-62885108
info@spring-chem.com China 2065 57

Related articles


View Lastest Price from o-Phthalaldehyde manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-15 o-Phthalaldehyde
643-79-8
US $0.00 / Kg/Drum 100g/Bag 99% 200mt Jinan Finer Chemical Co., Ltd
2021-08-31 1,2-Phthalic dicarboxaldehyde
643-79-8
US $50.00 / KG 1Kg/Bag 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-08-26 o-Phthalaldehyde
643-79-8
US $8.00 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd

o-Phthalaldehyde Spectrum


643-79-8(o-Phthalaldehyde)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved