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Maleic anhydride

Maleic anhydride
Maleic anhydride structure
Chemical Name:
Maleic anhydride
MA;MAN;mala;BM-10;Maleic;NSC 9568;108-31-6;Lytron 820;NSC 137651;NSC 137652
Molecular Formula:
Formula Weight:
MOL File:

Maleic anhydride Properties

Melting point:
51-56 °C(lit.)
Boiling point:
200 °C(lit.)
vapor density 
3.4 (vs air)
vapor pressure 
0.16 mm Hg ( 20 °C)
refractive index 
1.4688 (estimate)
Flash point:
218 °F
storage temp. 
Store at RT.
0.8 (550g/l, H2O, 20℃)Hydrolysis
explosive limit
Water Solubility 
79 g/100 mL (25 ºC)
Moisture Sensitive
Henry's Law Constant
(atm?m3/mol): Not applicable - reacts with water
Exposure limits
NIOSH REL: TWA 1 ppm (0.25 mg/m3), IDLH 10 ppm; OSHA PEL: TWA 0.25 ppm; ACGIH TLV: TWA 0.25 ppm with an intended change of 0.1 ppm.
Stable. Combustible. Incompatible with water, strong oxidizing agents, alkali metals, strong bases, amines, most common metals, polymerization catalysts and accelerators.
Indirect Additives used in Food Contact Substances
175.105; 175.300; 175.320; 177.1680
CAS DataBase Reference
108-31-6(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
EPA Substance Registry System
Maleic anhydride (108-31-6)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302-H314-H317-H334-H372-H373-H370-H402
Precautionary statements  P260-P264-P270-P272-P273-P301+P330+P331+P310-P303+P361+P353+P310+P363-P305+P351+P338+P310-P307+P311-P405-P501-P260h-P501a-P261-P280-P284-P303+P361+P353-P304+P340+P310-P305+P351+P338-P342+P311
Hazard Codes  C
Risk Statements  22-34-42/43
Safety Statements  22-26-36/37/39-45
RIDADR  UN 2215 8/PG 3
WGK Germany  1
RTECS  ON3675000
Autoignition Temperature 870 °F
HS Code  2917 14 00
HazardClass  8
PackingGroup  III
Toxicity LD50 orally in Rabbit: 1090 mg/kg LD50 dermal Rabbit 2620 mg/kg
NFPA 704
3 1

Maleic anhydride price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 63200 Maleic anhydride puriss., ≥99.0% (NT) 108-31-6 100g-f $34.4 2020-08-18 Buy
Sigma-Aldrich 63200 Maleic anhydride puriss., ≥99.0% (NT) 108-31-6 500g-f $40.7 2020-08-18 Buy
TCI Chemical M0005 Maleic Anhydride >99.0%(GC)(T) 108-31-6 25g $17 2020-06-24 Buy
TCI Chemical M0005 Maleic Anhydride >99.0%(GC)(T) 108-31-6 500g $20 2020-06-24 Buy
Alfa Aesar A12178 Maleic anhydride, 98+% 108-31-6 1000g $25 2020-06-24 Buy

Maleic anhydride Chemical Properties,Uses,Production


Maleic Anhydride (MAN) is an organic compound with the chemical formula C4H203. It is the acid anhydride of maleic acid and in its pure state it is a colourless or white solid with an acrid odour. Maleic anhydride is truly a remarkable molecule in that it possesses two types of chemical functionality making it uniquely useful in chemical synthesis and applications.
Maleic Anhydride
Maleic Anhydride is a multifunctional chemical intermediate with applications in several fields of chemical industry. Its major end use is as feedstock in the production of unsaturated polyester resins (UPR).
These resins are used both in glass-reinforced and in unreinforced applications. The UPR end uses includes a wide range of applications in construction, marine and automobile industries.
In addition, Maleic Anhydride can also be used as raw material in the production of 1,4-butanediol (BDO), gamma- butyrolactone and tetrahydrofuran (THF). It is important to highlight that BDO is one of the world's fastest growing chemicals in the last years.

Chemical Properties

Maleic anhydride is colorless needles, white lumps, or pellets. Irritating, choking odor.

Physical properties

White, hydroscopic crystals (usually shipped as briquettes). Odor threshold concentration is 0.32 ppm (quoted, Amoore and Hautala, 1983).


In the manufacture of polyester resins, fumaric acid, agricultural pesticides, and alkyl resins


Maleic Anhydride is heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides.


In Diels-Alder syntheses (as a dienophile), manufacture of alkyd-type of resins, dye intermediates, pharmaceuticals, agricultural chemicals (maleic hydrazide, malathion), in copolymerization reactions.


ChEBI: A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.

Production Methods

Maleic anhydride was traditionally manufactured by the oxidation of benzene or other aromatic compounds. As of 2006, only a few smaller plants continue to use benzene; due to rising benzene prices, most maleic anhydride plants now use n-butane as a feedstock.
In both cases, benzene and butane are fed into a stream of hot air, and the mixture is passed through a catalyst bed at high temperature. The ratio of air to hydrocarbon is controlled to prevent the mixture from catching on fire. Vanadium pentoxide and molybdenum trioxide are the catalysts used for the benzene route, whereas vanadium and phosphorus oxides are used for the butane route.
2 CH3CH2CH2CH3 + 7 O2 → 2 C2H2(CO)2O + 8 H2O.


To a flask equipped with a Dean-Stark trap, condenser, and mechanical stirrer is added 116 gm (1.0 mole) of maleic acid and 120 ml of tetrachloroethane. The contents are heated, the water (18 ml, 1.0 mole) distilled off as the azeotrope, and the residue distilled under reduced pressure to afford 87.7 gm (89.5%) of the anhydride, b.p. 82-84°C (15 mm), m.p. 53°C. The residue remaining in the flask consists of about 10 gm of fumaric acid, m.p. 287°C.
Fumaric and maleic acids both give maleic anhydride on heating. Fumaric acid must first be heated to a higher temperature to effect its conversion to maleic acid prior to its dehydration.
Preparation of Maleic Anhydride


maleic anhydride: A colourlesssolid, C4H2O3, m.p. 53°C, the anhydrideof cis-butenedioic acid (maleicacid). It is a cyclic compound with aring containing four carbon atomsand one oxygen atom, made by thecatalytic oxidation of benzene or itsderivatives at high temperatures. It isused mainly in the manufacture ofalkyd and polyester resins andcopolymers.


The chemistry of maleic anhydride is very rich, reflecting its ready availability and bifunctional reactivity. It hydrolyzes, producing maleic acid, cis-HOOC–CH=CH–COOH. With alcohols, the halfester is generated, e.g., cis-HOOC–CH=CH–COOCH3.
Maleic anhydride is a potent dienophile in Diels-Alder reactions. It is also a ligand for low-valent metal complexes, examples being Pt(PPh3)2(MA) and Fe(CO)4(MA).
Maleic anhydride dimerizes in a photochemical reaction to form cyclo butane tetra carboxylic dianhydride (CBTA). This compound is used in the production of polyimides and as an alignment film for liquid crystal displays.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 6676, 1995 DOI: 10.1021/jo00126a013

General Description

Colorless crystalline needles, flakes, pellets, rods, briquettes, lumps or a fused mass. Melts at 113°F. Shipped both as a solid and in the molten state. Vapors, fumes and dusts strong irritate the eyes, skin and mucous membranes. Flash point 218°F. Autoignition temperature 890°F. Used to make paints and plastics and other chemicals.

Air & Water Reactions

Soluble in water. Reacts slowly with water to form maleic acid and heat.

Reactivity Profile

Maleic anhydride react vigorously on contact with oxidizing materials. Reacts exothermically with water or steam. Undergoes violent exothermic decomposition reactions, producing carbon dioxide, in the presence of strong bases (sodium hydroxide, potassium hydroxide, calcium hydroxide), alkali metals (lithium, sodium, potassium), aliphatic amines (dimethylamine, trimethylamine), aromatic amines (pyridine, quinoline) at temperatures above 150° C [Vogler, C. A. et al., J. Chem. Eng. Data, 1963, 8, p. 620]. A 0.1% solution of pyridine (or other tertiary amine) in Maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Maleic anhydride is known as an excellent dienophile in the Diels-Alder reaction to produce phthalate ester derivatives. These reactions can be extremely violent, as in the case of 1-methylsilacyclopentadiene [J. Organomet., Chem., 1979, 179, c19]. Maleic anhydride undergoes a potentially explosive exothermic Diels-Alder reaction with 1-methylsilacyclopenta-2,4-diene at 150C [Barton, T. J., J. Organomet. Chem., 1979, 179, C19], and is considered an excellent dieneophile for Diels-alder reactions [Felthouse, Timothy R. et al. "Maleic anhydride , Maleic Acid, and Fumaric Acid." Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 2005].


Irritant to tissue. Dermal and respiratory sensitization. Questionable carcinogen.

Health Hazard

Inhalation causes coughing, sneezing, throat irritation. Skin contact causes irritation and redness. Vapors cause severe eye irritation; photophobia and double vision may occur.

Fire Hazard

Behavior in Fire: When heated above 300°F in the presence of various materials may generate heat and carbon dioxide. Will explode if confined.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. A corrosive irritant to eyes, skin, and mucous membranes. Can cause pulmonary edema. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A pesticide. Combustible when exposed to heat or flame; can react vigorously on contact with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. Reacts with water or steam to produce heat. Violent reaction with bases (e.g., sodmm hydroxide, potassium hydroxide, calcium hydroxide), dkah metals (e.g., sodium, potassium), amines (e.g., dimethylamine, triethylamine), lithium, pyridine. To fight fire, use alcohol foam. Incompatible with cations. When heated to decomposition (above 150℃) it emits acrid smoke and irritating fumes. See also ANHYDRIDES.

Potential Exposure

Maleic anhydride is used in unsaturated polyester resins; Agricultural chemical, and lubricating additives; in the manufacture of unsaturated polyester resins; in the manufacture of fumaric acid; in alkyd resin manufacture; in the manufacture of pesticides e.g., malathion, maleic hydrazide, and captan).

Environmental Fate

Chemical/Physical. Reacts with water forming maleic acid (Bunton et al., 1963). Anticipated products from the reaction of maleic anhydride with ozone or OH radicals in the atmosphere are carbon monoxide, carbon dioxide, aldehydes, and esters (Cupitt, 1980).

Solubility in organics

(wt % at 25 °C):
Acetone (227), benzene (50), carbon tetrachloride (0.60), chloroform (52.5), ethyl acetate (112), ligroin (0.25), toluene (23.4), o-xylene (19.4) (Windholz et al., 1983). Soluble in alcohol and 1,4- dioxane (Hawley, 1981).


UN2215 Maleic anhydride, Hazard class: 8; Labels: 8-Corrosive material.
Maleic Anhydride is commercialized and transported in the solid and molten forms. The molten Maleic Anhydride is transported at temperatures ranging from 60 to 80°C in well-insulated tank containers or road tankers provided with heating devices. In the solid form, it can be transported as pastilles, which are usually packed in polyethylene bags of 25 kg and transported either by rail tanker or by truck.

Purification Methods

Crystallise it from *benzene, CHCl3, CH2Cl2 or CCl4. Sublime it under reduced pressure. [Skell et al. J Am Chem Soc 108 6300 1986, Beilstein 17 III/IV 5897, 17/11 V 55.]


Reacts slowly with water (hydrolyzes) to form maleic acid, a medium-strong acid. Dust may form explosive mixture with air. Reacts with strong oxidizers, oil, water, alkali metals; strong acids; strong bases. Violent reaction with alkali metals and amines above 66C. Dangerous reaction with oxidizers, amines, alkali metals, and hydroxides. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur)

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration: care must be taken that complete oxidation to nontoxic products occurs.

Maleic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

Maleic anhydride Suppliers

Global( 385)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Lihe Biotechnology Co.,ltd
13315122300 86-13315122300 CHINA 213 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 China 886 50
Capot Chemical Co.,Ltd.
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Hebei Minshang Biotechnology Co., Ltd
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Yancheng Green Chemicals Co.,Ltd
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Hebei Chishuo Biotechnology Co., Ltd.
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View Lastest Price from Maleic anhydride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-09-17 Maleic anhydride
US $36.00 / KG/Tin 10g 99.5% 10Tons Hebei Lihe Biotechnology Co.,Ltd
2020-06-17 Maleic anhydride
US $100.00 / g/Bag 1Kg/Bag Above 99% 5000kg/month Shijiazhuang Suking Biotechnology Co .,Ltd.
2019-04-02 Maleic anhydride; 2,5-Furandione; MA Manufacturer; In stock GMP Factory
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.

Maleic anhydride Spectrum

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