4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
- CAS No.
- 39793-31-2
- Chemical Name:
- 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
- Synonyms
- DAO-IN-2;79793-31-2;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor;Thieno[2,3-b]pyrrole-5-carboxylic acid;4-Thieno[3,2-b]pyrrole-5-carboxylic acid;4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID;4H-thieno[2,3-d]pyrrole-5-carboxylic acid;4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE)
- CBNumber:
- CB9349944
- Molecular Formula:
- C7H5NO2S
- Molecular Weight:
- 167.19
- MDL Number:
- MFCD07368542
- MOL File:
- 39793-31-2.mol
- MSDS File:
- SDS
Melting point | 180 °C |
---|---|
Boiling point | 437.4±25.0 °C(Predicted) |
Density | 1.609 |
storage temp. | Sealed in dry,2-8°C |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml |
form | Beige solid |
pka | 4.36±0.30(Predicted) |
color | Light brown to gray |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 22-26-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 760250 | 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid 97% | 39793-31-2 | 500mg | $31.6 | 2023-06-20 | Buy |
Sigma-Aldrich | 138000 | D-Amino Acid Oxidase Inhibitor | 39793-31-2 | 50mg | $110 | 2023-01-07 | Buy |
Alfa Aesar | H58200 | 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 97% | 39793-31-2 | 1g | $201.65 | 2024-03-01 | Buy |
Alfa Aesar | H58200 | 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 97% | 39793-31-2 | 5g | $770 | 2021-12-16 | Buy |
Cayman Chemical | 23894 | D-Amino Acid Oxidase Inhibitor ≥98% | 39793-31-2 | 250mg | $68 | 2024-03-01 | Buy |
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties,Uses,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053
General Description
A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | cherry@crovellbio.com | China | 18419 | 58 |
View Lastest Price from 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
39793-31-2
|
US $1.00 / kg | 1kg | 98% | 200kg | Career Henan Chemical Co |
- 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
39793-31-2
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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