Mestinon
- CAS No.
- 101-26-8
- Chemical Name:
- Mestinon
- Synonyms
- PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
- CBNumber:
- CB9356274
- Molecular Formula:
- C9H13BrN2O2
- Molecular Weight:
- 261.12
- MDL Number:
- MFCD00079283
- MOL File:
- 101-26-8.mol
- MSDS File:
- SDS
| Melting point | 154 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Very soluble in water and in ethanol (96 per cent). |
| color | White to Almost white |
| Merck | 14,7977 |
| BCS Class | 3 |
| InChIKey | VNYBTNPBYXSMOO-UHFFFAOYSA-M |
| CAS DataBase Reference | 101-26-8(CAS DataBase Reference) |
| FDA UNII | KVI301NA53 |
| EPA Substance Registry System | Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H317 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-43 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU5270000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991. | |||||||||
| NFPA 704 |
|
Mestinon price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P9797 | Pyridostigmine bromide | 101-26-8 | 1g | $53.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR3120 | Pyridostigmine Bromide pharmaceutical secondary standard, certified reference material | 101-26-8 | 500MG | $182 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP1033 | Pyridostigmine bromide British Pharmacopoeia (BP) Reference Standard | 101-26-8 | 50MG | $247 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1586009 | Pyridostigmine bromide United States Pharmacopeia (USP) Reference Standard | 101-26-8 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | P1339 | Pyridostigmine Bromide >98.0%(HPLC)(T) | 101-26-8 | 5g | $37 | 2024-03-01 | Buy |
Mestinon Chemical Properties,Uses,Production
Description
Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Chemical Properties
White Solid
Uses
Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.
Definition
ChEBI: Pyridostigmine bromide is a pyridinium salt.
brand name
Mestinon (Valeant); Regonol (Sandoz).
General Description
Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.
Biochem/physiol Actions
Acetylcholinesterase inhibitor.
Clinical Use
Myasthenia gravis
Drug interactions
Potentially hazardous interactions with other drugs
Aminoglycosides, clindamycin and polymyxins
antagonise effects of pyridostigmine.
Metabolism
Pyridostigmine undergoes hydrolysis by cholinesterases and is also metabolised in the liver. It appears that 75% of the plasma clearance of pyridostigmine depends on renal function. 3-Hydroxy-N-methylpyridinium has been identified as one of the 3 metabolites isolated from the urine. Pyridostigmine is excreted mainly in the urine as unchanged drug and metabolites.
Mestinon Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Wuhan Chemwonders Technology Inc. | 027-85778276 | info@chemwonders.com | CHINA | 176 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Mestinon manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-15 | Mestinon
101-26-8
|
US $0.00 / KG | 1KG | 99% | 20T | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2023-04-13 | Mestinon
101-26-8
|
US $35.00 / kg | 1kg | 99% | 5000 Ton | Hebei Duling International Trade Co. LTD | |
 |
2021-11-02 | Mestinon
101-26-8
|
US $420.00 / Kg/Bag | 1KG | 99% | 1000kg | Baoji Guokang Healthchem co.,ltd |