Rivastigmine
- CAS No.
- 123441-03-2
- Chemical Name:
- Rivastigmine
- Synonyms
- RIVASTIGMINE HYDROGEN TARTRATE;EXELON;Rivastigmine base;mine;Rivastig;cabalatine;Revastigmine;RIVASTIGMINE;RivastigiMine;S-RivastigMine
- CBNumber:
- CB8328151
- Molecular Formula:
- C14H22N2O2
- Molecular Weight:
- 250.34
- MDL Number:
- MFCD00871496
- MOL File:
- 123441-03-2.mol
- MSDS File:
- SDS
| alpha | D20 -32.1° (c = 5 in ethanol) |
|---|---|
| Boiling point | 316.2±34.0 °C(Predicted) |
| Density | 1.038±0.06 g/cm3(Predicted) |
| Flash point | 145℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Powder |
| pka | pKa 8.99 (Uncertain) |
| CAS DataBase Reference | 123441-03-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | PKI06M3IW0 |
| NCI Drug Dictionary | Exelon |
| ATC code | N06DA03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H411 |
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 |
| RIDADR | UN 2810 6.1 / PGIII |
| HS Code | 2924296000 |
Rivastigmine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3343 | Rivastigmine certified reference material, pharmaceutical secondary standard | 123441-03-2 | 0.2ML | $228 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1604836 | Rivastigmine | 123441-03-2 | 0.1ml | $460 | 2024-03-01 | Buy |
| TRC | R540995 | (S)-Rivastigmine | 123441-03-2 | 2g | $350 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 61620 | (S)-Rivastigmine | 123441-03-2 | 5G | $1380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008913 | Rivastigmine 95.00% | 123441-03-2 | 5G | $2945.25 | 2021-12-16 | Buy |
Rivastigmine Chemical Properties,Uses,Production
Uses
Antidepressant
Definition
ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
brand name
Exelon (Novartis).
General Description
Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.
Pharmacokinetics
Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.
Clinical Use
Mild-moderate dementia in Alzheimer’s disease
Idiopathic Parkinson’s disease
Drug interactions
Potentially hazardous interactions with other drugs
Muscle relaxants: enhances effect of suxamethonium;
antagonises effect of non-depolarising muscle
relaxants.
Metabolism
Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.
Rivastigmine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Related articles
- An AChE inhibitor---Rivastigmine
- Rivastigmine is a slowly reversible AChE inhibitor and BuChE inhibitor approved for use in mild-to-moderate AD Rivastigmine is....
- Apr 28，2022
View Lastest Price from Rivastigmine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-27 | Rivastigmine
123441-03-2
|
US $110.00-90.00 / kilogram | 1kilogram | 99% | 10 tons/per week | Henan Tengmao Chemical Technology Co. LTD | |
 |
2023-09-01 | Rivastigmine
123441-03-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-06-15 | Rivastigmine
123441-03-2
|
US $3810.00 / Kg/Bag | 1KG | 99% | 100kg | Baoji Guokang Bio-Technology Co., Ltd. |
-
- Rivastigmine
123441-03-2
- US $110.00-90.00 / kilogram
- 99%
- Henan Tengmao Chemical Technology Co. LTD
-
- Rivastigmine
123441-03-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Rivastigmine
123441-03-2
- US $3810.00 / Kg/Bag
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
123441-03-2(Rivastigmine)Related Search:
1of4