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2,4-Dinitrofluorobenzene structure
Chemical Name:
DNF;DNPF;DNFB;FDNB;2,4-Dnfb;Sanger's ;NSC 33519;DNF OR DNFB;Zhou′s Ligand;SANGER REAGENT
Molecular Formula:
Formula Weight:
MOL File:

2,4-Dinitrofluorobenzene Properties

Melting point:
25-27 °C(lit.)
Boiling point:
178 °C25 mm Hg(lit.)
1.482 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.569(lit.)
Flash point:
>230 °F
storage temp. 
chloroform: 0.1 g/mL, clear
Liquid or Low Melting Crystals
Yellow to brownish
Specific Gravity
Water Solubility 
400 mg/L (25 ºC)
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
70-34-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA Substance Registry System
Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,T,Xn
Risk Statements  22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
Safety Statements  22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  CZ7800000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29049085
Hazardous Substances Data 70-34-8(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

2,4-Dinitrofluorobenzene price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 42085 1-Fluoro-2,4-dinitrobenzene purum p.a., ≥98.0% (GC) 70-34-8 50g $108 2018-11-13 Buy
Sigma-Aldrich 42085 1-Fluoro-2,4-dinitrobenzene purum p.a., ≥98.0% (GC) 70-34-8 250g $314 2018-11-13 Buy
TCI Chemical A5512 2,4-Dinitrofluorobenzene [for HPLC Labeling] >99.0%(GC) 70-34-8 5g $42 2018-11-22 Buy
TCI Chemical A5512 2,4-Dinitrofluorobenzene [for HPLC Labeling] >99.0%(GC) 70-34-8 25g $125 2018-11-22 Buy
Alfa Aesar A11871 1-Fluoro-2,4-dinitrobenzene, 99% 70-34-8 5g $27.4 2018-11-13 Buy

2,4-Dinitrofluorobenzene Chemical Properties,Uses,Production

Chemical Properties

Yellow solid


A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.


ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.

General Description

Clear yellow crystals or yellow crystalline solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Fire Hazard

2,4-Dinitrofluorobenzene is probably combustible.

Contact allergens

DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata

Safety Profile

Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.

Purification Methods

Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]

2,4-Dinitrofluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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