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2,4-Dinitrofluorobenzene

2,4-Dinitrofluorobenzene
2,4-Dinitrofluorobenzene structure
CAS No.
70-34-8
Chemical Name:
2,4-Dinitrofluorobenzene
Synonyms
DNF;DNPF;DNFB;FDNB;2,4-Dnfb;NSC 33519;Sanger's ;1-Fluoro-2;DNF OR DNFB;Zhou′s Ligand
CBNumber:
CB9442373
Molecular Formula:
C6H3FN2O4
Formula Weight:
186.1
MOL File:
70-34-8.mol

2,4-Dinitrofluorobenzene Properties

Melting point:
25-27 °C (lit.)
Boiling point:
178 °C/25 mmHg (lit.)
Density 
1.482 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.569(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
chloroform: 0.1 g/mL, clear
form 
Liquid or Low Melting Crystals
color 
Yellow to brownish
Specific Gravity
1.482
Water Solubility 
400 mg/L (25 ºC)
Merck 
14,4172
BRN 
398632
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
70-34-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
D241E059U6
NIST Chemistry Reference
Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA Substance Registry System
2,4-Dinitrofluorobenzene (70-34-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS06,GHS07,GHS05
Signal word  Warning
Hazard statements  H301-H311-H318-H331-H341-H300-H302-H315-H317-H319-H335-H373
Precautionary statements  P264-P270-P272-P301+P310+P330-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P405-P501-P261-P280-P305+P351+P338-P201-P301+P310a-P501a
Hazard Codes  C,T,Xn
Risk Statements  22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
Safety Statements  22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  CZ7800000
Hazard Note  Toxic
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29049085

2,4-Dinitrofluorobenzene price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 42085 1-Fluoro-2,4-dinitrobenzene purum p.a., ≥98.0% (GC) 70-34-8 50g $120 2021-12-16 Buy
Sigma-Aldrich 42085 1-Fluoro-2,4-dinitrobenzene purum p.a., ≥98.0% (GC) 70-34-8 250g $340 2021-12-16 Buy
TCI Chemical A5512 2,4-Dinitrofluorobenzene [for HPLC Labeling] >99.0%(GC) 70-34-8 5g $42 2021-12-16 Buy
TCI Chemical A5512 2,4-Dinitrofluorobenzene [for HPLC Labeling] >99.0%(GC) 70-34-8 25g $123 2021-12-16 Buy
Alfa Aesar A11871 1-Fluoro-2,4-dinitrobenzene, 99% 70-34-8 25g $81.4 2021-12-16 Buy

2,4-Dinitrofluorobenzene Chemical Properties,Uses,Production

Chemical Properties

Yellow solid

Uses

A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.

Uses

1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.

Definition

ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.

General Description

Clear yellow crystals or yellow crystalline solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Fire Hazard

2,4-Dinitrofluorobenzene is probably combustible.

Contact allergens

DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata

Biochem/physiol Actions

1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing.

Safety Profile

Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.

Purification Methods

Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]

2,4-Dinitrofluorobenzene synthesis

97-00-7
70-34-8
Synthesis of 2,4-Dinitrofluorobenzene from 2,4-Dinitrochlorobenzene

2,4-Dinitrofluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products


2,4-Dinitrofluorobenzene Spectrum


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