BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- CAS No.
- 227947-06-0
- Chemical Name:
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- Synonyms
- CS-2260;EPI-001;BADGE-HCl-H2O;BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH;BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&;3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane;1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-;BADGE-HCl-H2O, 2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane
- CBNumber:
- CB9497287
- Molecular Formula:
- C21H27ClO5
- Molecular Weight:
- 394.89
- MDL Number:
- MFCD02683414
- MOL File:
- 227947-06-0.mol
- MSDS File:
- SDS
| Melting point | 67 °C |
|---|---|
| Boiling point | 601.0±55.0 °C(Predicted) |
| Density | 1.228±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 13.13±0.20(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | A9PRH4DC8H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29072300 | |||||||||
| NFPA 704 |
|
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 92427 | Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether analytical standard | 227947-06-0 | 25mg | $240 | 2024-03-01 | Buy |
| Sigma-Aldrich | 92427 | Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether analytical standard | 227947-06-0 | 100mg | $712 | 2024-03-01 | Buy |
| TCI Chemical | E1380 | EPI-001 | 227947-06-0 | 5MG | $71 | 2024-03-01 | Buy |
| TCI Chemical | E1380 | EPI-001 | 227947-06-0 | 25MG | $213 | 2024-03-01 | Buy |
| Cayman Chemical | 16970 | EPI-001 ≥95% | 227947-06-0 | 5mg | $57 | 2024-03-01 | Buy |
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Chemical Properties,Uses,Production
Uses
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator that inhibits androgen receptor expression and activity in prostate cancer. It is a novel androgen receptor antagonists that has the potential for treating prostate cancer.
Definition
ChEBI: Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether is the (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD). It has a role as an androgen antagonist. It is an organochlorine compound and a diether. It is functionally related to a bisphenol A and a glycerol.
Biological Activity
epi-001 is a small-molecule inhibitor of androgen receptor n-terminal domain. epi-001 could target the amino terminal domain of the ar and inhibit the protein-protein interactions which are necessary for ar transcriptional activity. the androgen receptor (ar) is involved in mediating the actions of male sex steroids. amplification and over-expression of androgen receptor gene may result in hormone-refractory prostate cancer [1].
in vitro
epi-001 inhibited the ligand-dependent argal4 transcriptional activity in lncap cells and the ligand-independent argal4 transcriptional activity in the crpc c4-2 cell line. in a panel of cell lines, epi-001 treatment decreased the mrna expression level of ar protein after 8 and 16 h treatment, such as androgen sensitive pca, crpc, lncap, c4-2, and lapc4 cell line. epi-001 dose-dependently inhibited the pca/crpc cell growth [2].
in vivo
intravenous injection of epi-001 significantly reduced the weight of benign prostates and blocked the growth of prostate cancer xenograft from noncastrated mature mice. epi-001 caused tumor regression of crpc. in male mice bearing lncap xenografts, after treated with epi- 001 by i.v. injection for 2 weeks, the tumor size was less than half of the control group [3].
References
andersen r j, mawji n r, wang j, et al. regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor[j]. cancer cell, 2010, 17(6): 535-546.brand l j, olson m e, ravindranathan p, et al. epi-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer[j]. oncotarget, 2015, 6(6): 3811.sadar m d. small molecule inhibitors targeting the “achilles' heel” of androgen receptor activity[j]. cancer research, 2011, 71(4): 1208-1213.
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Heze Development Zone chuangli Chemical Co., Ltd. | +86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 877 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
View Lastest Price from BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-09 | BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
227947-06-0
|
US $1.00 / KG | 1KG | 95--99% | 1ton | Career Henan Chemical Co |
-
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
227947-06-0
- US $1.00 / KG
- 95--99%
- Career Henan Chemical Co