RO 106-9920
- CAS No.
- 62645-28-7
- Chemical Name:
- RO 106-9920
- Synonyms
- RO 106-9920;Ro 106 9920,Ro 1069920;Ro 106-9920 DISCONTINUED;TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE;6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE;Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
- CBNumber:
- CB9728932
- Molecular Formula:
- C10H7N5OS
- Molecular Weight:
- 245.26
- MDL Number:
- MFCD06660085
- MOL File:
- 62645-28-7.mol
RO 106-9920 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 557550 | Ro 106-9920 | 62645-28-7 | 1mg | $159 | 2024-03-01 | Buy |
| Cayman Chemical | 15373 | Ro 106-9920 ≥95% | 62645-28-7 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 15373 | Ro 106-9920 ≥95% | 62645-28-7 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 15373 | Ro 106-9920 ≥95% | 62645-28-7 | 10mg | $158 | 2024-03-01 | Buy |
| Usbiological | 256474 | Ro 106-9920 | 62645-28-7 | 10mg | $409 | 2021-12-16 | Buy |
RO 106-9920 Chemical Properties,Uses,Production
Uses
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
Definition
ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide.
Biological Activity
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
RO 106-9920 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |