5-Nitro-1,10-phenanthroline
- CAS No.
- 4199-88-6
- Chemical Name:
- 5-Nitro-1,10-phenanthroline
- Synonyms
- 5-NP;5-Nitro-1;NITROFERROIN;TIMTEC-BB SBB008850;5-nitro-10-phenanthroline;5-Nitro-1,10-phenthroline;5-Nitro-1,10-phenathroline;5-NITRO-1,10-PHENANTHROLINE;1,10-Phenanthroline, 5-nitro-;5-Nitro-1,10-phenanthroline>
- CBNumber:
- CB9747931
- Molecular Formula:
- C12H7N3O2
- Molecular Weight:
- 225.2
- MDL Number:
- MFCD00004981
- MOL File:
- 4199-88-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Nitro-1,10-phenanthroline ≥97%, crystalline | N8501 | 1g | $266 |
| 5-Nitro-1,10-phenanthroline ≥97%, crystalline | N8501 | 5g | $948 |
| 5-Nitro-1,10-phenanthroline >98.0%(HPLC)(T) | N0214 | 1g | $77 |
| 5-Nitro-1,10-phenanthroline | N503463 | 100mg | $75 |
| 5-Nitro-1,10-phenanthroline | J95272 | 25g | $954 |
| More product size | |||
| Melting point | 202-204 °C(lit.) |
|---|---|
| Boiling point | 366.71°C (rough estimate) |
| Density | 1.2844 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Alcohol,Benzene |
| form | crystalline |
| pka | pK1:3.232(+1) (25°C) |
| color | yellow to orange |
| biological source | synthetic |
| Water Solubility | insoluble |
| BRN | 196245 |
| InChI | InChI=1S/C12H7N3O2/c16-15(17)10-7-8-3-1-5-13-11(8)12-9(10)4-2-6-14-12/h1-7H |
| InChIKey | PDDBTWXLNJNICS-UHFFFAOYSA-N |
| SMILES | N1C2C(=C([N+]([O-])=O)C=C3C=2N=CC=C3)C=CC=1 |
| CAS DataBase Reference | 4199-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1,10-Phenanthroline, 5-nitro- (4199-88-6) |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-36-24/25-22 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Nitro-1,10-phenanthroline price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N8501 | 5-Nitro-1,10-phenanthroline ≥97%, crystalline | 4199-88-6 | 1g | $266 | 2026-04-30 | Buy |
| Sigma-Aldrich | N8501 | 5-Nitro-1,10-phenanthroline ≥97%, crystalline | 4199-88-6 | 5g | $948 | 2026-04-30 | Buy |
| TCI Chemical | N0214 | 5-Nitro-1,10-phenanthroline >98.0%(HPLC)(T) | 4199-88-6 | 1g | $77 | 2026-04-30 | Buy |
| TRC | N503463 | 5-Nitro-1,10-phenanthroline | 4199-88-6 | 100mg | $75 | 2021-12-16 | Buy |
| AK Scientific | J95272 | 5-Nitro-1,10-phenanthroline | 4199-88-6 | 25g | $954 | 2021-12-16 | Buy |
5-Nitro-1,10-phenanthroline Chemical Properties,Uses,Production
Chemical Properties
Light yellow to yellow-brown crystalline powder
Uses
5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.
Biochem/physiol Actions
Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.
Synthesis
66-71-7
4199-88-6
General procedure for the synthesis of 5-nitro-1,10-o-phenanthroline from 1,10-phenanthroline: 1,10-phenanthroline (10 g, 55.49 mmol) was slowly added to fuming nitric acid (10 ml), which was subsequently dissolved in concentrated sulfuric acid (20 ml). The reaction was stirred at 160°C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ice water and the pH was adjusted with saturated aqueous sodium hydroxide solution to 3. The resulting yellow solid was collected by filtration, washed with water and finally concentrated under reduced pressure to give 5-nitro-1,10-phenanthroline (6.2 g, 99% yield).
Purification Methods
Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]
References
[1] Organic Letters, 2010, vol. 12, # 12, p. 2876 - 2879
[2] Patent: KR101757629, 2017, B1. Location in patent: Paragraph 0135 - 0139
[3] Chemistry Letters, 2013, vol. 42, # 7, p. 700 - 702
[4] Supramolecular Chemistry, 2013, vol. 25, # 12, p. 798 - 805
[5] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 11,
5-Nitro-1,10-phenanthroline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3590 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8736 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 5-Nitro-1,10-phenanthroline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 5-Nitro-1,10-phenanthroline
4199-88-6
|
US $32.00-423.00 / g | 1g | 0.98 | 10kg | Shanghai UCHEM Inc. | |
 |
2026-04-22 | 5-Nitro-1,10-phenanthroline
4199-88-6
|
US $56.00 / mg | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-12 | 5-Nitro-1,10-phenanthroline
4199-88-6
|
US $1.00-45.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Nitro-1,10-phenanthroline
4199-88-6
- US $32.00-423.00 / g
- 0.98
- Shanghai UCHEM Inc.
-
- 5-Nitro-1,10-phenanthroline
4199-88-6
- US $56.00 / mg
- 99.78%
- TargetMol Chemicals Inc.
-
- 5-Nitro-1,10-phenanthroline
4199-88-6
- US $1.00-45.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
