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2-Nitrophenol structure
Chemical Name:
Nsc 1552;o-Nitrofenol;O-NITROPHENOL;2-NITROPHENOL;2-nitro-pheno;o-nitro-pheno;2-Nitrylphemol;Phenol,2-nitro-;Phenol, o-nitro-;o-nitrophenol[qr]
Molecular Formula:
Formula Weight:
MOL File:

2-Nitrophenol Properties

Melting point:
43-45 °C
Boiling point:
214-216 °C
vapor pressure 
1 mm Hg ( 49.3 °C)
refractive index 
Flash point:
108 °C
storage temp. 
Store in dark!
2 g/L (25°C)
7.17(at 25℃)
Clear pale yellow
PH Range
Colorless (5.0) to yellow (7.0)
Aromatic odor
Water Solubility 
2 g/L (25 ºC)
Light Sensitive
Henry's Law Constant
At 20 °C: 11.1 at pH 8.1, 11.0 at pH 10.2, 8.9 at pH 11.9, 6.7 at pH 13.7 (wetted-wall column-UV, Zhang et al., 2003)
Stable. Incompatible with strong bases, strong oxidizing agents.
Major Application
High voltage capacitors, inks, energetic materials, corrosion inhibitors, fertilizer, food storage, enzyme assays, detecting microorganisms, immunotherapy, drugs
CAS DataBase Reference
88-75-5(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-nitro-(88-75-5)
EPA Substance Registry System
o-Nitrophenol (88-75-5)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H373-H402-H412-H225-H301+H311+H331-H370-H302-H315-H319-H335
Precautionary statements  P210-P260-P280-P301+P310-P311-P261-P305+P351+P338-P273-P280h-P302+P352
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-52/53-33-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  26-61-45-36/37-16-7-36-28
RIDADR  UN 1663 6.1/PG 3
WGK Germany  2
RTECS  SM2100000
Autoignition Temperature 550 °C
HazardClass  6.1
PackingGroup  III
HS Code  29089000
Toxicity LD50 orally in mice, rats: 1.297, 2.828 g/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972)

2-Nitrophenol price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N19702 2-Nitrophenol 98% 88-75-5 5g $27.9 2021-12-16 Buy
Sigma-Aldrich 8.06790 2-Nitrophenol for synthesis 88-75-5 100 g $46.06 2021-12-16 Buy
Sigma-Aldrich 8.06790 2-Nitrophenol for synthesis 88-75-5 500 g $67.89 2021-12-16 Buy
Sigma-Aldrich N19702 2-Nitrophenol 98% 88-75-5 1kg $126 2021-12-16 Buy
TCI Chemical N0219 2-Nitrophenol >98.0%(GC)(T) 88-75-5 25g $17 2021-12-16 Buy

2-Nitrophenol Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline solid


manufacture of dyes, paint colorings, rubber chemicals, and fungicides. Indicator in 2% alcohol solution. pH: 5.0 colorless, 7.0 yellow, but the color change is not sharp and cannot be used where CO2 is present; as reagent for glucose.


2-Nitrophenol is an intermediate in dyestuff production and a chemical indicator.


2-Nitrophenol is a building block used as an acid-base indicator and corrosion inhibitor for aluminum-copper alloy. It is also used to make dyes, paint coloring, rubber chemicals, and substances that kill molds.


ChEBI: A member of the class of 2-nitrophenols that is phenol in which one of the hydrogens that is ortho to the hydroxy group has been replaced by a nitro group.

Synthesis Reference(s)

Canadian Journal of Chemistry, 67, p. 220, 1989 DOI: 10.1139/v89-037
Tetrahedron, 44, p. 4555, 1988 DOI: 10.1016/S0040-4020(01)86158-5

General Description

Yellow solid. Sinks in and mixes slowly with water.

Air & Water Reactions

Water insoluble.

Reactivity Profile

2-Nitrophenol is a yellow, crystalline material, moderately toxic, low melting point (45° C). When heated to decomposition 2-Nitrophenol emits toxic fumes of oxides of nitrogen. In molten form violent reaction with strong alkali (85 % potassium hydroxide) [491 M, 1975, p. 342]. Reaction product with chlorosulfuric acid decomposes violently at room temperature [Vervalin, C. H., Hydrocarbon Proc., 1976, 55(9), p. 321].


Toxic by ingestion.

Health Hazard

Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes causes irritation. Can be absorbed through the intact skin to give same symptoms as for inhalation.

Fire Hazard

Special Hazards of Combustion Products: Toxic and irritating fumes of unburned material and oxides of nitrogen can form in fire.

Environmental Fate

Biological. A microorganism, Pseudomonas putida, isolated from soil degraded 2-nitrophenol to nitrite. Degradation by enzymatic mechanisms produced nitrite and catechol. Catechol subsequently degraded to β-ketoadipic acid (Zeyer and Kearney, 1984). When 2-nitrophenol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, 100% biodegradation with rapid adaptation was achieved after 7 d (Tabak et al., 1981). In a similar study, 2-nitrophenol degraded rapidly from flooded alluvial and pokkali (organic matter-rich acid sulfate) soils that were inoculated with parathion-enrichment culture containing 5- day-old cultures of Flavobacterium sp. ATCC 27551 and Pseudomonas sp. ATCC 29353 (Sudhaker-Barik and Sethunathan, 1978a). 2-Nitrophenol disappeared completely with the formation of nitrite, particularly in the inoculated soils rather than in the uninoculated soils.
Groundwater. Nielsen et al. (1996) studied the degradation of 2-nitrophenol in a shallow, glaciofluvial, unconfined sandy aquifer in Jutland, Denmark. As part of the in situ microcosm study, a cylinder that was open at the bottom and screened at the top was installed through a cased borehole approximately 5 m below grade. Five liters of water was aerated with atmospheric air to ensure aerobic conditions were maintained. Groundwater was analyzed weekly for approximately 3 months to determine 2-nitrophenol concentrations with time. The experimentally determined first-order biodegradation rate constant and corresponding half-life were 0.05/d and 13.86 d, respectively.
Photolytic. A second-order reaction rate constant of 9 x 10-13 cm3/molecule?sec was reported for the reaction of 2-nitrophenol and OH radicals in the atmosphere (Atkinson, 1985). Chemical/Physical. Oxidation by Fenton’s reagent (hydrogen peroxide and Fe3+) produced nitrohydroquinone and 3-nitrocatechol (Andersson et al., 1986). In an aqueous solution (initial pH 5.0), 2-nitrophenol (100 μM) reacted with Fenton’s reagent (35 μM). After 60-min and 4-h, about 50 and 90% of the 2-nitrophenol was destroyed, respectively. The pH of the solution decreased due to the formation of nitric acid (Lipczynska-Kochany, 1991).

Purification Methods

Crystallise 2-nitrophenol from EtOH/water, water, EtOH, *benzene or MeOH/pet ether (b 70-90o). It can be steam distilled. Petrucci and Weygandt [Anal Chem 33 275 1961] crystallised it from hot water (twice), then EtOH (twice), followed by fractional crystallisation from the melt (twice), drying over CaCl2 in a vacuum desiccator and then in a drying pistol. The 4-nitrobenzoate had m 141o (from EtOH). [Beilstein 6 IV 1246.]

2-Nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Nitrophenol Spectrum

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