1-メチル-D-トリプトファン
1-メチル-D-トリプトファン 物理性質
- 融点 :
- 242-245 °C(lit.)
- 比旋光度 :
- 12.4o (C = 2 IN ACETIC ACID)
- 沸点 :
- 429.3±35.0 °C(Predicted)
- 比重(密度) :
- 1.28
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 溶解性:
- DMSO に可溶 (25 mg/ml 以上)。
- 酸解離定数(Pka):
- 2.26±0.10(Predicted)
- 外見 :
- 白色から淡褐色の結晶性粉末。
- 色:
- 白い
- 光学活性 (optical activity):
- [α]22/D +12.4°, c = 2 in acetic acid
- 水溶解度 :
- Soluble to 5 mM in water with gentle warming
- 安定性：:
- -20°C の DMSO 溶液で最大 1 か月間保存できます。
- InChIKey:
- ZADWXFSZEAPBJS-SNVBAGLBSA-N
1-メチル-D-トリプトファン 価格
もっと(9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-6092 |
1-メチル-D-トリプトファン
1-Methyl-D-tryptophan |
110117-83-4 |
1g |
￥40000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-6092 |
1-メチル-D-トリプトファン
1-Methyl-D-tryptophan |
110117-83-4 |
5g |
￥112500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-6092 |
1-Methyl-D-tryptophan |
110117-83-4 |
10g |
￥180000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQA-6092 |
1-Methyl-D-tryptophan |
110117-83-4 |
25g |
￥360000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
452483 |
1-メチル-D-トリプトファン 95%
1-Methyl-D-tryptophan 95% |
110117-83-4 |
250mg |
￥8880 |
2024-03-01 |
購入 |
1-メチル-D-トリプトファン 化学特性,用途語,生産方法
効能
抗悪性腫瘍薬
説明
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD
+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth
in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC
50 = 7 μM) that is effective
in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8
+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
使用
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
1-メチル-D-トリプトファン 上流と下流の製品情報
原材料
準備製品
1-メチル-D-トリプトファン 生産企業
Global( 192)Suppliers
1-メチル-D-トリプトファン スペクトルデータ(1HNMR、IR)
110117-83-4(1-メチル-D-トリプトファン)キーワード:
- 110117-83-4
- 1-METHYL-D-TRYPTOPHAN
- 1-Methyl-D-tryptophane
- 1-METHYL-D-TRYPTOPHAN 95%
- (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
- IndoxiMod
- Indoximod (NLG-8189）
- NLG-8189
- 1-Me-D-Trp
- D-Trp(Me)-OH
- Me-D-Trp
- H-D-Trp(1-Me)-OH
- INDOXIMOD;1-METHYL-D-TRYPTOPHAN;1-METHYL-D-TRYPTOPHANE
- (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
- D-Tryptophan, 1-methyl-
- 1-METHYL-D-TRYPTOPHAN USP/EP/BP
- (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
- インドキシモド