1-METHYL-D-TRYPTOPHAN
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- CAS-Nr.
- 110117-83-4
- Englisch Name:
- 1-METHYL-D-TRYPTOPHAN
- Synonyma:
- Me-D-Trp;NLG-8189;IndoxiMod;1-Me-D-Trp;D-Trp(Me)-OH;H-D-Trp(1-Me)-OH;Indoximod (NLG-8189）;1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;D-Tryptophan, 1-methyl-
- CBNumber:
- CB0467553
- Summenformel:
- C12H14N2O2
- Molgewicht:
- 218.25
- MOL-Datei:
- 110117-83-4.mol
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1-METHYL-D-TRYPTOPHAN Eigenschaften
- Schmelzpunkt:
- 242-245 °C(lit.)
- alpha
- 12.4o (C = 2 IN ACETIC ACID)
- Siedepunkt:
- 429.3±35.0 °C(Predicted)
- Dichte
- 1.28
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- Soluble in DMSO (greater than 25 mg/ml).
- pka
- 2.26±0.10(Predicted)
- Aggregatzustand
- White to light brown crystalline powder.
- Farbe
- White
- Optische Aktivität
- [α]22/D +12.4°, c = 2 in acetic acid
- Wasserlöslichkeit
- Soluble to 5 mM in water with gentle warming
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- ZADWXFSZEAPBJS-SNVBAGLBSA-N
1-METHYL-D-TRYPTOPHAN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD
+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth
in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC
50 = 7 μM) that is effective
in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8
+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
Verwenden
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.
1-METHYL-D-TRYPTOPHAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-METHYL-D-TRYPTOPHAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 192)Lieferanten
110117-83-4()Verwandte Suche:
- 1-METHYL-D-TRYPTOPHAN
- 1-Methyl-D-tryptophane
- 1-METHYL-D-TRYPTOPHAN 95%
- (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
- IndoxiMod
- Indoximod (NLG-8189）
- NLG-8189
- 1-Me-D-Trp
- D-Trp(Me)-OH
- Me-D-Trp
- H-D-Trp(1-Me)-OH
- INDOXIMOD;1-METHYL-D-TRYPTOPHAN;1-METHYL-D-TRYPTOPHANE
- (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
- D-Tryptophan, 1-methyl-
- 1-METHYL-D-TRYPTOPHAN USP/EP/BP
- (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
- 110117-83-4
- Amino Acid Derivatives
- Peptide Synthesis
- Specialty Synthesis
- Tryptophan
- Inhibitors
- Amino Acid Derivatives
- Peptide Synthesis
- Tryptophan
