TNP-470
TNP-470 物理性質
- 融点 :
- 90-93°C
- 比旋光度 :
- D24 -46.6° (c = 0.44 in CHCl3)
- 比重(密度) :
- 1.26±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO：>15mg/mL
- 酸解離定数(Pka):
- 7.19±0.46(Predicted)
- 外見 :
- 白色から淡黄色の固体
- 色:
- 白色から淡黄色のろう状
- 安定性：:
- 吸湿性
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0120-1997 |
TNP-470 |
129298-91-5 |
10mg |
￥37500 |
2020-09-21 |
購入 |
|
Sigma-Aldrich Japan
|
T1455 |
≥98% (HPLC)
TNP-470 ≥98% (HPLC) |
129298-91-5 |
5mg |
￥36300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
T1455 |
≥98% (HPLC)
TNP-470 ≥98% (HPLC) |
129298-91-5 |
25mg |
￥113000 |
2024-03-01 |
購入 |
TNP-470 化学特性,用途語,生産方法
外観
無色～ほとんど白色, 固体
溶解性
ジメチルスルホキシドに可溶（3mg/ml）
説明
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC
50 = 2 μM), blocking endothelial cell proliferation
in vitro and angiogenesis
in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
使用
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
定義
ChEBI: A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.
一般的な説明
TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.
生物活性
Analog of Fumagillin ((2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2 -methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5] oct-6-yl] 2,4,6,8-decatetraenedioic acid ester) that displays potent antiangiogenic activity in vitro and in vivo . Inhibits methionine aminopeptidase type II (MetAP2).
TNP-470 上流と下流の製品情報
原材料
準備製品
TNP-470 生産企業
Global( 57)Suppliers
129298-91-5(TNP-470)キーワード:
- 129298-91-5
- NSC642492
- O-(chloroacetylcarbamoyl)fumagillol
- O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470
- [(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate
- AGM-1470
- Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- Tnp-470
- N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
- O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470
- (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- O-Chloracetyl-carbamoyl fumagillol
- (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2
- Carbamic acid, N-(2-chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- TNP-470 - CAS 129298-91-5 - Calbiochem
- 6-O-chloroacetylcarbamoylfumagillol
- TNP470,TNP 470
- Fumagillin Impurity 1
- クロロアセチルカルバミン酸[(3R)-4β-[(2R,3R)-2-メチル-3-(3-メチル-2-ブテニル)オキシラニル]-5α-メトキシ-1-オキサスピロ[2.5]オクタン-6α-イル]
- クロロアセチルカルバミド酸(3R)-4β-[(2R,3R)-2-メチル-3-(3-メチル-2-ブテニル)オキシラニル]-5α-メトキシ-1-オキサスピロ[2.5]オクタン-6α-イル
- (3R,4S,5S,6R)-5-メトキシ-4-[(2R,3R)-2-メチル-3-(3-メチルブタ-2-エン-1-イル)オキシラン-2-イル]-1-オキサスピロ[2.5]オクタン-6-イル N-(2-クロロアセチル)カルバマート
- (3R)-4β-[(2R)-2-メチル-3β-(3-メチル-2-ブテニル)オキシラン-2α-イル]-5α-メトキシ-6α-(クロロアセチルカルバモイルオキシ)-1-オキサスピロ[2.5]オクタン
- TNP-470
- O-(クロロアセチルカルバモイル)フマギロール