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没食子酸プロピル

没食子酸プロピル 化学構造式
121-79-9
CAS番号.
121-79-9
化学名:
没食子酸プロピル
别名:
没食子酸プロピル;プロガリンP;ニパガリンP;テノックスPG;プロピルガラート;n-プロピルガラート;n-プロピルガレート;3,4,5-トリヒドロキシ安息香酸プロピル;ガルス酸プロピル;プロピル ガレート 没食子酸;没食子酸N-プロピル;没食子酸プロピル標準品;没食子酸 n-プロピル;プロパ-1-イル=3,4,5-トリヒドロキシベンゾアート;プロピル=3,4,5-トリヒドロキシベンゾアート(別名 没食子酸プロピル);没食子酸N‐プロピル
英語化学名:
Propyl gallate
英語别名:
nipa49;tenoxpg;Nipa 49;Tenox PG;FEMA 2947;FEMA 2974;Sustane PG;NCI-C50588;PROGALLIN P;nci-c505888
CBNumber:
CB1465703
化学式:
C10H12O5
分子量:
212.2
MOL File:
121-79-9.mol

没食子酸プロピル 物理性質

融点 :
146-149 °C(lit.)
沸点 :
312.03°C (rough estimate)
比重(密度) :
1.210
屈折率 :
1.5140 (estimate)
FEMA :
2947 | PROPYL GALLATE
闪点 :
187℃
貯蔵温度 :
Store below +30°C.
溶解性:
ethanol: 50 mg/mL
外見 :
powder
酸解離定数(Pka):
8.11(at 25℃)
色:
White to light beige
水溶解度 :
0.35 g/100 mL (25 ºC)
Merck :
14,7859
BRN :
1877976
InChIKey:
ZTHYODDOHIVTJV-UHFFFAOYSA-N
CAS データベース:
121-79-9(CAS DataBase Reference)
NISTの化学物質情報:
Benzoic acid, 3,4,5-trihydroxy-, propyl ester(121-79-9)
EPAの化学物質情報:
Propyl gallate (121-79-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-43-36/37/38
Sフレーズ  24-37-36-26
WGK Germany  2
RTECS 番号 LW8400000
TSCA  Yes
HSコード  29182950
有毒物質データの 121-79-9(Hazardous Substances Data)
毒性 LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.)
化審法 (3)-1583
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P272 汚染された作業衣は作業場から出さないこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P321 特別な処置が必要である(このラベルの... を見よ)。
P333+P313 皮膚刺激または発疹が生じた場合:医師の診断/手当てを 受けること。
P501 内容物/容器を...に廃棄すること。

没食子酸プロピル 価格 もっと(41)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC216645 3,4,5-トリヒドロキシ安息香酸プロピル
Propyl 3,4,5-trihydroxybenzoate
121-79-9 25g ¥2900 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01FLC216645 3,4,5-トリヒドロキシ安息香酸プロピル
Propyl 3,4,5-trihydroxybenzoate
121-79-9 10g ¥7900 2020-09-21 購入
東京化成工業 G0018 没食子酸プロピル >98.0%(T)
Propyl Gallate >98.0%(T)
121-79-9 25g ¥2500 2021-03-23 購入
東京化成工業 G0018 没食子酸プロピル >98.0%(T)
Propyl Gallate >98.0%(T)
121-79-9 500g ¥16200 2021-03-23 購入
関東化学株式会社(KANTO) 13158-3A 没食子酸n‐プロピル
n‐Propyl gallate
121-79-9 100g ¥4800 2021-03-23 購入

没食子酸プロピル MSDS


3,4,5-Trihydroxybenzoic acid propyl ester

没食子酸プロピル 化学特性,用途語,生産方法

外観

白色〜わずかにうすい赤褐色, 結晶性粉末〜粉末

定義

本品は、没食子酸(*)のプロピルエステルであり、次の化学式で表される。
参照表示名称:没食子酸

溶解性

水に不溶。熱湯, エタノールに易溶。エタノールに溶け、水に溶けにくい。

用途

油脂およびバターの酸化防止剤

化粧品の成分用途

酸化防止剤、香料

効能

酸化防止剤

説明

It caused contact dermatitis in a baker and in a female confectioner who fried doughnuts, primarily sensitized by her night cream; the margarine probably contained gallates.

説明

Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver. Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia. Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food. Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.

化学的特性

Propyl gallate is an odorless powder having a slightly bitter taste. It functions particularly well in stabilizing animal fats and vegetable oils. With a melting point of 148°C, propyl gallate loses its effectiveness during heat processing and is therefore not suitable in frying applications that involve temperatures exceeding 190°C. Propyl gallate chelates iron ions and forms an unappealing, blue–black complex. Hence, it is always used with chelators such as citric acid to eliminate the pro-oxidative iron and copper catalysts. Good synergism is obtained with BHA and BHT; however, application with TBHQ is not permitted. For additional details, refer to Burdock (1997).

化学的特性

Propyl gallate is a white, odorless or almost odorless crystalline powder, with a bitter astringent taste that is not normally noticeable at the concentrations employed as an antioxidant.

化学的特性

white to light beige crystalline powder

使用

Propyl Gallate is a known inhibitor of Tyrosinase, a polyphenol oxidase, which is an important enzyme in pigment biosynthesis in various organisms. It has also recently been seen to boost biodiesel li pid biosynthesis in cultures.

使用

Antioxidant for cosmetics, foods, fats, oils, ethers, emulsions, waxes, transformer oils.

使用

propyl gallate is an anti-oxidant with preservative properties.

使用

Propyl Gallate is an antioxidant that is the n-propylester of 3,4,5-tri- hydroxybenzoic acid. natural occurrence of propyl gallate has not been reported. it is commercially prepared by esterification of gallic acid with propyl alcohol followed by distillation to remove excess alcohol.

調製方法

Propyl gallate is prepared by the esterification of 3,4,5-trihydroxybenzoic acid (gallic acid) with n-propanol. Other alkyl gallates are prepared similarly using an appropriate alcohol of the desired alkyl chain length.

製造方法

Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.

一般的な説明

Fine white to creamy-white crystalline powder. Odorless or with a faint odor. Melting point 150°C. Insoluble in water. Slightly bitter taste.

空気と水の反応

Insoluble in water.

反応プロフィール

Propyl gallate can react with oxidizing agents. Incompatible with strong acids, strong bases and strong reducing agents. Darkens in the presence of iron and iron salts. Contact with metals should be avoided .

危険性

Use in foods restricted to 0.02% of fat con- tent.

火災危険

Propyl gallate is combustible.

応用例(製薬)

Propyl gallate has become widely used as an antioxidant in cosmetics, perfumes, foods, and pharmaceuticals since its use in preventing autoxidation of oils was first described in 1943.It is primarily used, in concentrations up to 0.1% w/v, to prevent the rancidity of oils and fats;it may also be used at concentrations of 0.002% w/v to prevent peroxide formation in ether, and at 0.01% w/v to prevent the oxidation of paraldehyde. Synergistic effects with other antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene have been reported. Propyl gallate is also said to possess some antimicrobial properties;
Studies have shown that, when added to powder blends containing ketorolac, propyl gallate significantly increases the drug stability in the preparation.
Other alkyl gallates are also used as antioxidants and have approximately equivalent antioxidant properties when used in equimolar concentration; however, solubilities vary;
Propyl gallate has also been investigated for its therapeutic properties, mainly in animal studies.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

接触アレルゲン

This gallate ester (E 311) is an antioxidant frequently used in the food, cosmetic, and pharmaceutical industries to prevent the oxidation of unsaturated fatty acids into rancid-smelling compounds. It causes cosmetic dermatitis mainly from lipsticks and induced contact dermatitis in a baker, and in a female confectioner, primarily sensitized by her night cream, who fried doughnuts the margarine probably containing gallates.

安全性プロファイル

Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.

毒性学

Propyl gallate (n-propyl-3,4,5-trihydroxybenzoate) is used in vegetable oils and butter. When 1.2 or 2.3% propyl gallate was added to feed for rats, loss of weight was observed. This may be due to the rats reluctance to eat food that was contaminated with the bitter taste of propyl gallate. When it was given for 10 to 16 months at the 2 to 3% level, 40% of the rats died within the first month and the remainder showed severe growth inhibition. Autopsies of rats indicated kidney damage resulting from the ingestion of propyl gallate. However, no other animal studies show serious problems and further studies indicated that propyl gallate does not cause serious chronic toxicities.

安全性

It has been reported, following animal studies, that propyl gallate has a strong contact sensitization potential.Propyl gallate has also produced cytogenic effects in CHO-K1 cells.However, despite this, there have been few reports of adverse reactions to propyl gallate.Those that have been described include contact dermatitis, allergic contact dermatitis,and methemoglobinemia in neonates.
The WHO has set an estimated acceptable daily intake for propyl gallate at up to 1.4 mg/kg body-weight.
(cat, oral): 0.4 g/kg
(mouse, oral): 1.7 g/kg
(rat, oral): 2.1 g/kg
(rat, IP): 0.38 g/kg

貯蔵

Propyl gallate is unstable at high temperatures and is rapidly destroyed in oils that are used for frying purposes.
The bulk material should be stored in a well-closed, nonmetallic container, protected from light, in a cool, dry place.

純化方法

Crystallise the ester from aqueous EtOH or *C6H6 (m 146-146.5o). [Beilstein 10 III 2078, 10 IV 2003.]

不和合性

The alkyl gallates are incompatible with metals, e.g. sodium, potassium, and iron, forming intensely colored complexes. Complex formation may be prevented, under some circumstances, by the addition of a sequestering agent, typically citric acid. Propyl gallate may also react with oxidizing materials.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM injections; oral, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

没食子酸プロピル 上流と下流の製品情報

原材料

準備製品


没食子酸プロピル 生産企業

Global( 537)Suppliers
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121-79-9(没食子酸プロピル)キーワード:


  • 121-79-9
  • Gallic acid propyl ester , PG
  • Propyl gallate, 98% 100GR
  • Propyl gallat
  • Propyl gallate,3,4,5-Trihydroxybenzoic acid propyl ester, Tenox PG
  • Propyl gallate 3g [121-79-9]
  • Propyl Gallate (200 mg)G2D2031.000mg/mg(dr)
  • Propyl Gallate (200 mg)
  • Propyl Gallate, USP
  • Propyl gallate SynonyMs: Propyl 3,4,5-trihydroxybenzoate
  • proply gallate
  • Propyl 3,4,5-trihydroxybenzoate 3,4,5-Trihydroxybenzoic acid propyl ester Tenox PG
  • Propyl 3,4,5-trihydroxybenzoate for synthesis
  • 3,4,5-TRIHYDROXYBENZENE-1-PROPYLCARBOXYLATE
  • 3,4,5-TRIHYDROXYBENZOIC ACID N-PROPYL ESTER
  • 3,4,5-TRIHYDROXYBENZOIC ACID PROPYL ESTER
  • n-propylesterof3,4,5-trihydroxybenzoicacid
  • Propyl galiate
  • propyl3,4,5-
  • Propylester kyseliny gallove
  • propylesterkyselinygallove
  • Sustane PG
  • Tenox PG
  • tenoxpg
  • GALLIC ACID N-PROPYL ESTER
  • GALLIC ACID PROPYL ESTER
  • FEMA 2947
  • FEMA 2974
  • n-Propyl Gallate (Ph. Eur.) pure, pharma grade
  • Propyl gallate 121-79-9 Propyl 3,4,5-trihydroxybenzoate
  • Propyl 3,4,5-trihydroxybenzoate 121-79-9 Propyl gallate
  • 没食子酸プロピル
  • プロガリンP
  • ニパガリンP
  • テノックスPG
  • プロピルガラート
  • n-プロピルガラート
  • n-プロピルガレート
  • 3,4,5-トリヒドロキシ安息香酸プロピル
  • ガルス酸プロピル
  • プロピル ガレート 没食子酸
  • 没食子酸N-プロピル
  • 没食子酸プロピル標準品
  • 没食子酸 n-プロピル
  • プロパ-1-イル=3,4,5-トリヒドロキシベンゾアート
  • プロピル=3,4,5-トリヒドロキシベンゾアート(別名 没食子酸プロピル)
  • 没食子酸N‐プロピル
  • 生化学
  • 抗酸化剤
  • 酸化防止剤
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