몰식자산프로필
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몰식자산프로필 속성
- 녹는점
- 146-149 °C(lit.)
- 끓는 점
- 312.03°C (rough estimate)
- 밀도
- 1.210
- 증기압
- 0Pa at 20℃
- 굴절률
- 1.5140 (estimate)
- 인화점
- 187℃
- 저장 조건
- Store below +30°C.
- 용해도
- 에탄올: 50mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.11(at 25℃)
- 색상
- 흰색~밝은 베이지
- 냄새
- 맛없는
- 수용성
- 0.35g/100mL(25℃)
- Merck
- 14,7859
- BRN
- 1877976
- InChIKey
- ZTHYODDOHIVTJV-UHFFFAOYSA-N
- LogP
- 1.8
- CAS 데이터베이스
- 121-79-9(CAS DataBase Reference)
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-43-36/37/38 | ||
안전지침서 | 24-37-36-26 | ||
WGK 독일 | 2 | ||
RTECS 번호 | LW8400000 | ||
TSCA | Yes | ||
HS 번호 | 29182950 | ||
유해 물질 데이터 | 121-79-9(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.) | ||
기존화학 물질 | KE-34290 |
몰식자산프로필 C화학적 특성, 용도, 생산
순도시험
(1) 융점 : 이 품목을 105℃에서 2시간 건조할 때, 그 융점은 146~150℃이어야 한다.
(2) 용상 : 이 품목 0.5g을 에탄올 10mL에 녹일 때, 그 액의 색은 비색표준용액 C보다 진하여서는 아니 된다.
(3) 염화물 : 이 품목 1.5g에 물 75mL를 가하여 약 70℃에서 5분간 가온한 다음 약 20℃로 식히고 여과하여 여액 25mL에 묽은질산 6mL를 가하고 이를 시험용액으로 하여 염화물시험법에 따라 시험할 때, 이 양은 0.01N 염산 0.4mL에 대응하는 양 이하이어야 한다.
(4) 황산염 : 위 (3)의 여액 25mL에 묽은염산 1mL를 가하여 이를 시험용액으로 하여 황산염시험법에 따라 시험할 때, 그 양은 0.01N 황산 0.4mL에 대응하는 양 이하이어야 한다.
(5) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(6) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
(7) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.
확인시험
(1) 이 품목 0.5g을 수산화나트륨시액 10mL에 녹이고 이를 증류하여 초류액 약 4mL를 취하면 이액은 징명하며 이를 가열하면 프로판올냄새가 난다.
(2) 이 품목 0.1g을 에탄올 5mL에 녹이고 묽은염화제이철시액 1방울을 가하면 자색을 나타낸다.
정량법
미리 유리여과기(1G4)를 110℃에서 30분간 건조하고 데시케이타 중에서 방냉한 후 무게를 정밀히 달아 둔다. 이 품목을 건조한 다음 약 0.2g을 정밀히 달아 물 150mL를 가하여 끓인다. 이를 강하게 흔들어 섞어주면서 질산비스마스시액 50mL를 가하고 다시 수분간 흔들어 섞고 침전을 앞의 유리여과기로 여과하고 얼음물로 식힌 질산(1→300) 5mL씩으로 2회 씻는다. 이어서 청색리트머스지가 적색을 나타내지 않을 때 까지 얼음물로 씻은 후 110℃에서 3시간 건조하고 데시케이타 중에서 방냉한 후 다음 계산식에 따라 함량을 구한다.
강열잔류물
이 품목 1g을 취하여 강열잔류물시험법에 따라 시험할 때, 그 양은 0.1% 이하이어야 한다.
개요
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver. Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia. Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food. Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.화학적 성질
Propyl gallate is a white, odorless or almost odorless crystalline powder, with a bitter astringent taste that is not normally noticeable at the concentrations employed as an antioxidant.용도
Propyl Gallate is a known inhibitor of Tyrosinase, a polyphenol oxidase, which is an important enzyme in pigment biosynthesis in various organisms. It has also recently been seen to boost biodiesel li pid biosynthesis in cultures.생산 방법
Propyl gallate is prepared by the esterification of 3,4,5-trihydroxybenzoic acid (gallic acid) with n-propanol. Other alkyl gallates are prepared similarly using an appropriate alcohol of the desired alkyl chain length.제조 방법
Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.일반 설명
Fine white to creamy-white crystalline powder. Odorless or with a faint odor. Melting point 150°C. Insoluble in water. Slightly bitter taste.공기와 물의 반응
Insoluble in water.반응 프로필
Propyl gallate can react with oxidizing agents. Incompatible with strong acids, strong bases and strong reducing agents. Darkens in the presence of iron and iron salts. Contact with metals should be avoided .위험도
Use in foods restricted to 0.02% of fat con- tent.화재위험
Propyl gallate is combustible.Pharmaceutical Applications
Propyl gallate has become widely used as an antioxidant in cosmetics, perfumes, foods, and pharmaceuticals since its use in preventing autoxidation of oils was first described in 1943.It is primarily used, in concentrations up to 0.1% w/v, to prevent the rancidity of oils and fats;it may also be used at concentrations of 0.002% w/v to prevent peroxide formation in ether, and at 0.01% w/v to prevent the oxidation of paraldehyde. Synergistic effects with other antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene have been reported. Propyl gallate is also said to possess some antimicrobial properties;Studies have shown that, when added to powder blends containing ketorolac, propyl gallate significantly increases the drug stability in the preparation.
Other alkyl gallates are also used as antioxidants and have approximately equivalent antioxidant properties when used in equimolar concentration; however, solubilities vary;
Propyl gallate has also been investigated for its therapeutic properties, mainly in animal studies.
색상 색인 번호
This gallate ester (E 311) is an antioxidant frequently used in the food, cosmetic, and pharmaceutical industries to prevent the oxidation of unsaturated fatty acids into rancid-smelling compounds. It causes cosmetic dermatitis mainly from lipsticks and induced contact dermatitis in a baker, and in a female confectioner, primarily sensitized by her night cream, who fried doughnuts the margarine probably containing gallates.Toxicology
Propyl gallate (n-propyl-3,4,5-trihydroxybenzoate) is used in vegetable oils and butter. When 1.2 or 2.3% propyl gallate was added to feed for rats, loss of weight was observed. This may be due to the rats reluctance to eat food that was contaminated with the bitter taste of propyl gallate. When it was given for 10 to 16 months at the 2 to 3% level, 40% of the rats died within the first month and the remainder showed severe growth inhibition. Autopsies of rats indicated kidney damage resulting from the ingestion of propyl gallate. However, no other animal studies show serious problems and further studies indicated that propyl gallate does not cause serious chronic toxicities.Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.Safety
It has been reported, following animal studies, that propyl gallate has a strong contact sensitization potential.Propyl gallate has also produced cytogenic effects in CHO-K1 cells.However, despite this, there have been few reports of adverse reactions to propyl gallate.Those that have been described include contact dermatitis, allergic contact dermatitis,and methemoglobinemia in neonates.The WHO has set an estimated acceptable daily intake for propyl gallate at up to 1.4 mg/kg body-weight.
(cat, oral): 0.4 g/kg
(mouse, oral): 1.7 g/kg
(rat, oral): 2.1 g/kg
(rat, IP): 0.38 g/kg
저장
Propyl gallate is unstable at high temperatures and is rapidly destroyed in oils that are used for frying purposes.The bulk material should be stored in a well-closed, nonmetallic container, protected from light, in a cool, dry place.
Purification Methods
Crystallise the ester from aqueous EtOH or *C6H6 (m 146-146.5o). [Beilstein 10 III 2078, 10 IV 2003.]비 호환성
The alkyl gallates are incompatible with metals, e.g. sodium, potassium, and iron, forming intensely colored complexes. Complex formation may be prevented, under some circumstances, by the addition of a sequestering agent, typically citric acid. Propyl gallate may also react with oxidizing materials.Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM injections; oral, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.몰식자산프로필 준비 용품 및 원자재
원자재
준비 용품
몰식자산프로필 공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Jiurui Biology Chemistry Co.,Ltd. | +86-0744-8561603 +8619974416182 |
sales11@jiuruibiochem.com | China | 26 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
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Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21703 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9359 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29919 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 |
sales@nbinno.com | CHINA | 925 | 58 |