プロパルギルブロミド 化学特性,用途語,生産方法
外観
無色～うすい黄色, 澄明の液体
溶解性
水に不溶, エタノール, アセトンに易溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。
用途
農薬全般(中間体を含む) 医薬,医薬中間体
使用上の注意
不活性ガス封入
説明
Propargyl bromide is a Shock sensitive liquid, lachrymator. Supplied
as an 80% solution in toluene stabilized with magnesium
oxide. Alternative formulations are currently under
development.
化学的特性
yellow solution
使用
Used to make propargylic amines employed in enyne metathesis.1Employed in the propargylation of spiro ketones,2 allylic alcohols,3 and enone complexes.4
一般的な説明
A colorless to light yellow liquid substance with a sharp odor. Flash point 65°F. Denser than water and insoluble in water. Vapors are heavier than air. May be irritating to skin and eyes. Used to make other chemicals. 3-Bromopropyne may decompose explosively with mild shock.
空気と水の反応
Highly flammable. Insoluble in water.
反応プロフィール
3-Bromopropyne is soluble in alcohol, ether, chloroform, carbon tetrachloride and carbon disulfide. 3-Bromopropyne is highly flammable and a dangerous fire risk, sensitive to shock. 3-Bromopropyne is used in organic syntheses, preparation of resins and perfume intermediates [Hawley]. There is a high danger of formation of explosive metal acetylides, when 3-Bromopropyne comes in contact with copper, high-copper alloys, mercury, or silver.
危険性
Flammable, dangerous fire and explosion
risk. Irritant.
健康ハザード
3-Bromopropyne is very toxic via the oral route. If inhaled, may be harmful; contact may cause burns to skin and eyes.
火災危険
3-Bromopropyne detonates at 428F or more; ignites by impact. Emits highly toxic fumes of bromides when heated to decomposition. Reacts vigorously with oxidizing materials. Becomes shock-sensitive when mixed with chloropicrin. Unstable, avoid heat, flame, shock, and other chemicals
薬理学
Mode of action is considered
to be reaction with nucleophiles in living organisms.
安全性プロファイル
A poison by ingestion.
A dangerous fire hazard when exposed to
heat or flame. The aerated liquid may be
ignited by pressure. A dangerous, extremely
shock-sensitive explosive. It can detonate
when heated to 22O°C, by impact (especially
when mixed with chloropicrin), or when
heated whde confined. May explode on
contact with copper, high copper alloys,
mercury, or silver. Mixtures with
trichloronitromethane are shockand heat-
sensitive explosives. Can react vigorously
with oxidizing materials. To fight fire, use
water, foam, CO2, dry chemical. When
heated to decomposition it emits highly
toxic fumes of Br-. See also ACETYLENE
COMPOUNDS and BROMIDES.
代謝
Reacts slowly with water
to yield propargyl alcohol and bromide ion. It is expected
to move as a typical fumigant through the soil. Probably
not an ozone-depleting substance due to decomposition on
absorption of ultraviolet light.
プロパルギルブロミド 上流と下流の製品情報
原材料
準備製品