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セファドロキシル水和物

セファドロキシル水和物 化学構造式
66592-87-8
CAS番号.
66592-87-8
化学名:
セファドロキシル水和物
别名:
セファドロキシル水和物;(6R,7R)-7-[(R)-2-アミノ-2-(p-ヒドロキシフェニル)アセチルアミノ]-3-メチル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸·水和物;セファドロキシル·1水和物
英語化学名:
Cefadroxil
英語别名:
Baxan;CEFAMOX;Duracef;CEFADROXIL;Cefa-Drops;Cefradroxil;MJF-11567-3;AMOXYCILLIN;CEFADDROXIL;Cefadroxil hydrate
CBNumber:
CB4203658
化学式:
C16H17N3O5S.H2O
分子量:
381.41
MOL File:
66592-87-8.mol

セファドロキシル水和物 物理性質

融点 :
197 °C
貯蔵温度 :
-20°C Freezer
溶解性:
Slightly soluble in water, very slightly soluble in ethanol (96 per cen
酸解離定数(Pka):
pKa 1.38(H2O t=20±2 N2atmosphere) (Uncertain); 7.35(H2O t=20±2 N2atmosphere) (Uncertain);10.10(H2O t=20±2 N2atmosphere) (Uncertain)
外見 :
neat
InChIKey:
NBFNMSULHIODTC-CYJZLJNKSA-N
CAS データベース:
66592-87-8(CAS DataBase Reference)

安全性情報

主な危険性  Xn,Xi
Rフレーズ  36/37/38-42/43
Sフレーズ  26-36-36/37
WGK Germany  2
RTECS 番号 XI0337000

セファドロキシル水和物 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCC235750
Cefadroxil
66592-87-8 1g ¥11300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCC235750
Cefadroxil
66592-87-8 5g ¥23800 2018-12-26 購入
Sigma-Aldrich Japan C0650000 European Pharmacopoeia (EP) Reference Standard
Cefadroxil European Pharmacopoeia (EP) Reference Standard
66592-87-8 c0650000 ¥33600 2018-12-25 購入
Sigma-Aldrich Japan 1097104 United States Pharmacopeia (USP) Reference Standard
Cefadroxil United States Pharmacopeia (USP) Reference Standard
66592-87-8 200mg ¥71100 2018-12-25 購入
富士フイルム和光純薬株式会社(wako) W01USP1097104
Cefadroxil
66592-87-8 200mg ¥73500 2018-12-26 購入

セファドロキシル水和物 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

化学的特性

White Crystalline Solid

使用

cephalosporin antibacterial

使用

Semi-synthetic cephalosporin antibiotic. Antibacterial

定義

ChEBI: The hydrate that is the monohydrate of the cephalosporin cefadroxil.

brand name

Duricef (Bristol-Myers Squibb); Ultracef (Bristol Labs).

抗菌性

Resembles closely that of cefalexin

薬物動態学

Oral absorption: >90%
Cmax 250 mg oral: c. 9 mg/L after 1.2 h
500 mg oral: c. 18 mg/L after 1.2 h
Plasma half-life: 1–1.5 h
Plasma protein binding : 20%
Absorption is little affected by administration with food. Distribution is similar to that of cefalexin. It is eliminated unchanged by glomerular filtration and tubular secretion; 90% of the dose appears in the urine over 24 h, most in the first 6 h, producing concentrations exceeding 500 mg/L.

臨床応用

Cefadroxil (Duricef) is an orally active semisyntheticderivative of 7-ADCA, in which the 7-acyl group is the Dhydroxylphenylglycylmoiety. This compound is absorbedwell after oral administration to give plasma levels that reach75% to 80% of those of an equal dose of its close structuralanalog cephalexin. The main advantage claimed for cefadroxilis its somewhat prolonged duration of action, whichpermits once-a-day dosing. The prolonged duration of actionof this compound is related to relatively slow urinary excretionof the drug compared with other cephalosporins, butthe basis for this remains to be explained completely. Theantibacterial spectrum of action and therapeutic indications ofcefadroxil are very similar to those of cephalexin and cephradine.The D-p-hydroxyphenylglycyl isomer is much moreactive than the L-isomer.

臨床応用

It has been used for various community-acquired infections for which oral cephalosporins are appropriate.

副作用

Side effects described are those common to oral cephalosporins.

セファドロキシル水和物 上流と下流の製品情報

原材料

準備製品


セファドロキシル水和物 生産企業

Global( 98)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21968 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Wuhan DKY Technology Co.,Ltd. 027-81302488 18007166089
027-81302088 info@dkybpc.com;2851686510@qq.com China 2121 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32365 50
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9103 52

66592-87-8(セファドロキシル水和物)キーワード:


  • 66592-87-8
  • (6R,7R)-7-[(R)-2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
  • CEFAMOX
  • CEFADROXIL
  • CEFADROXIL MONOHYDRATE
  • P-HYDROXYCEPHALEXINE
  • monohydrate,(6r-(6-alpha,7-beta(r*)))-l)acetyl)amino)-3-methyl-8-oxo
  • Cefradroxil
  • (6R,7R)-7-[[(2R)-Amino-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate
  • Baxan
  • Cefa-Drops
  • Duracef
  • MJF-11567-3
  • p-Hydroxycephalexine Monohydrate
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-amino(4-hydroxyphenyl)acetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-
  • Cefdroxil(non-sterile)
  • 7-[[2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • AMOXYCILLIN
  • CEFADDROXIL
  • (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-3-methyl-8-oxo-, monohydrate, (6R-(6-alpha,7-beta(R*)))
  • Cefadroxil hydrate
  • (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-keto-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • (6R,7R)-7-[[(2R)-2-azanyl-2-(4-hydroxyphenyl)ethanoyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • Cefadroxil (125 mg)I1B319935ug/mg(ai)
  • Cefadroxil (200 mg)
  • Cefadroxil (125 mg)
  • Cefadroxill Monohydrate
  • Cefadroxil Monohydrate USP
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-(4-hydroxyphenyl)acetyl]aMino]-3-Methyl-8-oxo-,hydrate (1:1), (6R,7R)-
  • セファドロキシル水和物
  • (6R,7R)-7-[(R)-2-アミノ-2-(p-ヒドロキシフェニル)アセチルアミノ]-3-メチル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸·水和物
  • セファドロキシル·1水和物
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