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メチルセルロース

メチルセルロース 化学構造式
9004-67-5
CAS番号.
9004-67-5
化学名:
メチルセルロース
别名:
メチルセルロース (1,000-1,800mPas);メチルセルロース (13-18mPas);メチルセルロース (20-30mPas);メチルセルロース (3,500-5,600mPas);メチルセルロース (350-550mPas);メチルセルロース (7,000-10,000mPas);メチルセルロース (80-120mPas);コロゲル;メチルセルロース;セルロチル;セチチン;セチロース;ニセル;セルロースメチルエーテル;メトセル;チロース;セルメス;バゴラクス;ヒドロロース;メチル セルロス
英語化学名:
Methyl cellulose
英語别名:
MC;nicel;tylose;viscol;adulsin;Apolone;bagolax;cologel;edisolm;mco8000
CBNumber:
CB3474718
化学式:
C20H38O11
分子量:
454.50912
MOL File:
9004-67-5.mol

メチルセルロース 物理性質

融点 :
290-305 °C
比重(密度) :
1.01 g/cm3(Temp: 70 °C)
FEMA :
2696 | METHYL CELLULOSE
溶解性:
Practically insoluble in hot water, in acetone, in anhydrous ethanol and in toluene. It dissolves in cold water giving a colloidal solution.
外見 :
powder
色:
White, yellow-white or grayish-white
水溶解度 :
SOLUBLE IN COLD WATER
Merck :
14,6040
安定性::
Stable. Incompatible with strong oxidizing agents, bleach, perchloric acid, nitric acid, perchlorates, alkali nitrates, alkali nitrites, calcium oxide.
EPAの化学物質情報:
Methylcellulose (9004-67-5)

安全性情報

Sフレーズ  24/25
WGK Germany  3
RTECS 番号 FJ5959000
3
TSCA  Yes
HSコード  39129000
有毒物質データの 9004-67-5(Hazardous Substances Data)
化審法 (8)-186

メチルセルロース 価格 もっと(104)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MPB02155492 メチルセルロース
METHYL CELLULOSE
9004-67-5 100g ¥5500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01MPB02155492 メチルセルロース
METHYL CELLULOSE
9004-67-5 250g ¥11900 2021-03-23 購入
東京化成工業 M0185 メチルセルロース (3500-5600mPa・s)
Methyl Cellulose (3500-5600mPa·s, 2% in Water at 20°C)
9004-67-5 25g ¥2200 2021-03-23 購入
東京化成工業 M0185 メチルセルロース (3500-5600mPa・s)
Methyl Cellulose (3500-5600mPa·s, 2% in Water at 20°C)
9004-67-5 500g ¥6600 2021-03-23 購入
関東化学株式会社(KANTO) 18231-2A メチルセルロース(15cP)
Methyl cellulose (15cP)
9004-67-5 250g ¥10200 2021-03-23 購入

メチルセルロース MSDS


Methyl cellulose

メチルセルロース 化学特性,用途語,生産方法

外観

白色〜わずかにうすい褐色, 粉末

定義

本品は、セルロース(*)のメチルエーテルである。参照表示名称:セルロース

溶解性

水に溶ける。水溶液は、高温で熱ゲル化し、冷却するとともに元に戻る。

解説

セルロースのメチルエーテル.精製綿に水酸化ナトリウムを作用させ,アルカリセルロースをつくり,これに塩化メチルまたは硫酸ジメチルを作用させると得られる.無臭の白色~帯黄白色の無晶または繊維状の粉末あるいは粒.冷水に可溶,熱水に不溶.水に溶解するには80~90 ℃ に加温し,よくかくはんして分散させ,同温度で20~30 min 放置し,5~10 ℃ に冷却する.水溶液を加温すると,はじめ粘度は下がるが,ふたたび増加してゲル化する.置換度の大きいほうがゲル化の温度が低い.薬用として緩下剤に用いられ,また水溶液としてのり剤,粘ちゅう剤,エマルション(乳濁液)およびラテックス安定剤,香粧品などに用いられる.
森北出版「化学辞典(第2版)

化粧品の成分用途

結合剤、親水性増粘剤、乳化安定剤、香料

主な用途/役割

ユリア樹脂系接着剤、メラミン樹脂系接着剤、エマルション系接着剤の増粘剤として使用される。

化学的特性

white powder or (often) 2% solution in water, properties

化学的特性

Methylcellulose occurs as a white, fibrous powder or granules. It is practically odorless and tasteless. It should be labeled to indicate its viscosity type (viscosity of a 1 in 50 solution).

化学的特性

Methyl cellulose is a water soluble, gel-like substance with no odor and no taste.

使用

Methyl cellulose is used as a thickener and an emulsifier in various food and cosmetic products; as a gel in advanced cookery and as a lubricant. It is also involved in the treatment of constipation. It acts as a buffer additive in capillary electrophoresis to control electoosmotic flow for improved separations. In paper and textile industries, it is used as a sizing, thereby protecting the fibers from water or oil.

使用

Methylcellulose is a gum composed of cellulose in which the meth- oxyl groups replace the hydroxyl groups. it is soluble in cold water but insoluble in hot water. solutions increase in viscosity upon heating, gel at 50–55°c, and liquefy upon cooling. it is used in baked goods for moisture retention, and in fruit pie fillings for the reduction of water absorption into the pie crust during baking. it is also used in breaded shrimp where it functions to form an oil barrier film.

使用

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

使用

As a substitute for water-soluble gums; to render paper greaseproof, in adhesives, as thickening agent in cosmetics, as protective colloid in emulsions, as binder and stabilizer in foods. As fat replacer in the formulation of dietetic foods. Pharmaceutic aid (suspending agent).

製造方法

Prepared from wood pulp or cotton by treatment with alkali and methylation of alkali cellulose with methyl chloride.

調製方法

Methylcellulose is prepared from wood pulp (cellulose) by treatment with alkali followed by methylation of the alkali cellulose with methyl chloride. The product is then purified and ground to powder form.

brand name

Cologel (Lilly); Methocel A (Dow Chemical).

一般的な説明

Odorless white or creamy white fibrous powder. Tasteless.

空気と水の反応

Methyl cellulose is hygroscopic. Swells in water to a viscous, colloidal solid. Slightly water soluble.

反応プロフィール

Methyl cellulose is incompatible with strong oxidizing agents. Methyl cellulose is also incompatible with aminacrine HCl, chlorocresol, mercuric chloride, phenol resorcinol, tannic acid and silver nitrate.

火災危険

Flash point data for Methyl cellulose are not available; however, Methyl cellulose is probably combustible.

応用例(製薬)

Methylcellulose is widely used in oral and topical pharmaceutical formulations;
In tablet formulations, low- or medium-viscosity grades of methylcellulose are used as binding agents, the methylcellulose being added either as a dry powder or in solution.Highviscosity grades of methylcellulose may also be incorporated in tablet formulations as a disintegrant.Methylcellulose may be added to a tablet formulation to produce sustained-release preparations.
Tablet cores may also be spray-coated with either aqueous or organic solutions of highly substituted low-viscosity grades of methylcellulose to mask an unpleasant taste or to modify the release of a drug by controlling the physical nature of the granules. Methylcellulose coats are also used for sealing tablet cores prior to sugar coating.
Low-viscosity grades of methylcellulose are used to emulsify olive, peanut, and mineral oils.They are also used as suspending or thickening agents for orally administered liquids, methylcellulose commonly being used in place of sugar-based syrups or other suspension bases.Methylcellulose delays the settling of suspensions and increases the contact time of drugs, such as antacids, in the stomach.
High-viscosity grades of methylcellulose are used to thicken topically applied products such as creams and gels. In ophthalmic preparations, a 0.5–1.0% w/v solution of a highly substituted, high-viscosity grade of methylcellulose has been used as a vehicle for eye drops.However, hypromellose-based formulations are now preferred for ophthalmic preparations. Methylcellulose is also used in injectable formulations.
Therapeutically, methylcellulose is used as a bulk laxative; it has also been used to aid appetite control in the management of obesity, but there is little evidence supporting its efficacy.

Biochem/physiol Actions

Methyl cellulose is known to have a molecular size that might pass through placenta. It is useful in visualizing small bowel loops through its overlaps.

安全性プロファイル

A poison by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Methylcellulose is widely used in a variety of oral and topical pharmaceutical formulations. It is also extensively used in cosmetics and food products, and is generally regarded as a nontoxic, nonallergenic, and nonirritant material.
Following oral consumption, methylcellulose is not digested or absorbed and is therefore a noncaloric material. Ingestion of excessive amounts of methylcellulose may temporarily increase flatulence and gastrointestinal distension.
In the normal individual, oral consumption of large amounts of methylcellulose has a laxative action and medium- or high-viscosity grades are therefore used as bulk laxatives.
Esophageal obstruction may occur if methylcellulose is swallowed with an insufficient quantity of liquid. Consumption of large quantities of methylcellulose may additionally interfere with the normal absorption of some minerals. However, this and the other adverse effects discussed above relate mainly to the use of methylcellulose as a bulk laxative and are not significant factors when methylcellulose is used as an excipient in oral preparations. Methylcellulose is not commonly used in parenteral products, although it has been used in intra-articular and intramuscular injections. Studies in rats have suggested that parenterally administered methylcellulose may cause glomerulonephritis and hypertension.Methylcellulose is considered to be toxic by the intraperitoneal route of administration.
The WHO has not specified an acceptable daily intake of methylcellulose since the level of use in foods was not considered to be a hazard to health.
LD50 (mouse, IP): 275 g/kg

貯蔵

Methylcellulose powder is stable, although slightly hygroscopic. The bulk material should be stored in an airtight container in a cool, dry place.
Solutions of methylcellulose are stable to alkalis and dilute acids at pH 3–11, at room temperature. At pH less than 3, acid-catalyzed hydrolysis of the glucose–glucose linkages occurs and the viscosity of methylcellulose solutions is reduced.On heating, solution viscosity is reduced until gel formation occurs at approximately 50°C;
Methylcellulose solutions are liable to microbial spoilage and antimicrobial preservatives should therefore be used. Solutions may also be sterilized by autoclaving, although this process can decrease the viscosity of a solution.The change in viscosity after autoclaving is related to solution pH. Solutions at pH less than 4 had viscosities reduced by more than 20% subsequent to autoclaving.

不和合性

chlorocresol; mercuric chloride; phenol; resorcinol; tannic acid; silver nitrate; cetylpyridinium chloride; p-hydroxybenzoic acid; paminobenzoic acid; methylparaben; propylparaben; and butylparaben.
Salts of mineral acids (particularly polybasic acids), phenols, and tannins will coagulate solutions of methylcellulose, although this can be prevented by the addition of ethanol (95%) or glycol diacetate. Complexation of methylcellulose occurs with highly surface-active compounds such as tetracaine and dibutoline sulfate.
High concentrations of electrolytes increase the viscosity of methylcellulose mucilages owing to the ‘salting out’ of methylcellulose. With very high concentrations of electrolytes, the methylcellulose may be completely precipitated in the form of a discrete or continuous gel. Methylcellulose is incompatible with strong oxidizing agents.

規制状況(Regulatory Status)

GRAS listed. Accepted as a food additive in the USA, Europe and Japan. Included in the FDA Inactive Ingredients Database (sublingual tablets; IM injections; intrasynovial injections; nasal preparations; ophthalmic preparations; oral capsules, oral suspensions, and oral tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.Reported in the EPA TSCA inventory.

メチルセルロース 上流と下流の製品情報

原材料

準備製品


メチルセルロース 生産企業

Global( 330)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58
hdzhl biotechnology co., ltd
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sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
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Shandong chuangyingchemical Co., Ltd.
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sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
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Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2500 58
Chongqing Chemdad Co., Ltd
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9004-67-5(メチルセルロース)キーワード:


  • 9004-67-5
  • adulsin
  • Methyl cellulose, viscosity 8000 cPs
  • MODIFIED CELLULOSE
  • MODIFIED CELLULOSE, MC
  • 'TYLOSE'(R) MH 300
  • 'TYLOSE'(R) MH 1000
  • walsrodermc20000s
  • CELLULOSE METHYL ETHER
  • FEMA 2696
  • MethyI cellulose
  • METHYL CELLULOSE (CMC)
  • CMC (PURE AND TECHNICAL GRADES)
  • METHYL CELLULOSE, AVERAGE MW CA. 86,000 P
  • METHYL CELLULOSE, AVERAGE MW CA. 63,000 P
  • METHYL CELLULOSE CELL CULTURE TESTED
  • METHYLCELLULOSE, 400 CPS USP
  • METHYL CELLULOSE, AVERAGE MN CA. 41,000
  • METHYL CELLULOSE, AVERAGE MW 13,000-20,0 00
  • METHYLCELLULOSE, 1,500 CPS USP
  • METHOCEL(R) MC, 10-25 MPA.S
  • Apolone
  • Marpolose M 10000
  • Methoxycellulose
  • Methyl cellulose,Methocel MC, Methylcellulosum
  • Methylcellulose, synthesis grade
  • METHYL CELLULOSE, AVERAGE MN CA. 86,000
  • METHYL CELLULOSE, AVERAGE MN CA. 63,000
  • METHYL CELLULOSE, AVERAGE MN 14,000
  • Methylcellulose (1 g) (AS)
  • Methyl cellulose, viscosity 15 cPs
  • メチルセルロース (1,000-1,800mPas)
  • メチルセルロース (13-18mPas)
  • メチルセルロース (20-30mPas)
  • メチルセルロース (3,500-5,600mPas)
  • メチルセルロース (350-550mPas)
  • メチルセルロース (7,000-10,000mPas)
  • メチルセルロース (80-120mPas)
  • コロゲル
  • メチルセルロース
  • セルロチル
  • セチチン
  • セチロース
  • ニセル
  • セルロースメチルエーテル
  • メトセル
  • チロース
  • セルメス
  • バゴラクス
  • ヒドロロース
  • メチル セルロス
  • メチルセルロ-ス
  • メチルセルロース 4,000cp
  • メチルセルロース 400cp
  • アルキル(C1~2)セルロース
  • メチルセルロース (1,000-1,800mPa・s)
  • メチルセルロース (13-18mPa・s)
  • メチルセルロース (20-30mPa・s)
  • メチルセルロース (3,500-5,600mPa・s)
  • メチルセルロース (350-550mPa・s)
  • メチルセルロース (7,000-10,000mPa・s)
  • メチルセルロース (80-120mPa・s)
  • メチルセルロース (1,000-1,800mPa?s)
  • メチルセルロース (13-18mPa?s)
  • メチルセルロース (20-30mPa?s)
  • メチルセルロース (3,500-5,600mPa?s)
  • メチルセルロース (350-550mPa?s)
  • メチルセルロース (7,000-10,000mPa?s)
  • メチルセルロース (80-120mPa?s)
  • メチルセルロース (1000-1800mPa・s)
  • メチルセルロース (3500-5600mPa・s)
  • メチルセルロース (7000-10000mPa・s)
  • メチルセルロース(1500CP)
  • メチルセルロース(15CP)
  • メチルセルロース(25CP)
  • メチルセルロース(4000CP)
  • メチルセルロース(400CP)
  • メチルセルロース (1000-1800MPA?S)
  • メチルセルロース (3500-5600MPA?S)
  • メチルセルロース 1500
  • メチルセルロース 4000
  • メチルセルロース1.500CP
  • メチルセルロース100
  • メチルセルロース (AS)
  • メチルセルロース50
  • メチルセルロース15
  • メチルセルロース25
  • METHOCEL® MC
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