酢酸カスポフンギン

酢酸カスポフンギン 価格 もっと(8)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TRCC184900	酢酸カスポフンギン Caspofungin Acetate	179463-17-3	5mg	￥33300	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCC184900	酢酸カスポフンギン Caspofungin Acetate	179463-17-3	1mg	￥20400	2023-06-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCC184900	酢酸カスポフンギン Caspofungin Acetate	179463-17-3	25mg	￥116900	2023-06-01	購入
Sigma-Aldrich Japan	SML0425	カスポファンギン 二酢酸塩 ≥97% (HPLC) Caspofungin diacetate ≥97% (HPLC)	179463-17-3	5mg	￥28300	2024-03-01	購入
Sigma-Aldrich Japan	SML0425	カスポファンギン 二酢酸塩 ≥97% (HPLC) Caspofungin diacetate ≥97% (HPLC)	179463-17-3	25mg	￥101000	2024-03-01	購入

酢酸カスポフンギン 化学特性,用途語,生産方法

効能

抗真菌薬, 細胞壁合成阻害薬

商品名

カンサイダス (MSD)

説明

Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B₁ lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.

化学的特性

White Solid

使用

Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

定義

ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.

酢酸カスポフンギン 上流と下流の製品情報

原材料

準備製品

酢酸カスポフンギン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

179463-17-3(酢酸カスポフンギン)キーワード:

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• 179463-17-3
• Caspofungin acetate
• Caspofungin acetate [USAN:BAN:JAN]
• L 743,872
• L 743872
• L-743,872
• L-743872
• Mk 0991
• Mk0991
• Pneumocandin B0, 1-((4R,5S)-5-((2-aminoethyl)amino)-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-, diacetate (salt)
• 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneuMocandin B0 Diacetate
• 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneuMocandin B0 Diacetate
• L 743873
• Cancidas, L-743,872, MK-0991
• Cancidas (Caspofungin Acetate)
• Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)
• (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1
• Caspofungin acetate Cancidas
• 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0
• Caspofungin diacetate, >=98%
• Casp ungin Acetate
• Caspofungin Acetate (L 743872
• Caspofungin Acetate for lnjection
• Cancidas, ≥98%
• Casporfungin Acetate
• CF/KB(EUGMP,GMP)
• L 743872;L 743873;MK 0991;MK-0991
• Caspofungin acetate USP/EP/BP
• Caspofungin diacetate salt
• Caspofungin acetate B0
• pofungin Acetate
• 酢酸カスポフンギン
• カスポファンギン酢酸塩
• カスポファンジン酢酸塩
• カスポファンギン酢酸塩 (JAN)