ChemicalBook
Chinese english Germany Korea

3-ピコリン

3-ピコリン 化学構造式
108-99-6
CAS番号.
108-99-6
化学名:
3-ピコリン
别名:
3-ピコリン;β-ピコリン;3-メチルピリジン;3メチルピリジン;3-ピコリン(β-〃);Β‐ピコリン
英語化学名:
3-Picoline
英語别名:
BETAP;3-Mepy;3-PicoL;bPicolin;NSC 18251;B-Picoline;m-Picoline;3-PICOLINE;3-Prcoline;BETA-PICOLINE
CBNumber:
CB5355956
化学式:
C6H7N
分子量:
93.13
MOL File:
108-99-6.mol

3-ピコリン 物理性質

融点 :
-19 °C (lit.)
沸点 :
144 °C (lit.)
比重(密度) :
0.957 g/mL at 25 °C (lit.)
蒸気密度:
3.2 (vs air)
蒸気圧:
4.4 mm Hg ( 20 °C)
屈折率 :
n20/D 1.504(lit.)
闪点 :
97 °F
貯蔵温度 :
Flammables area
溶解性:
alcohol: miscible(lit.)
外見 :
Liquid
酸解離定数(Pka):
5.68(at 20℃)
色:
Clear yellow
PH:
10 (100g/l, H2O, 20℃)
臭い (Odor):
Unpleasant
爆発限界(explosive limit):
1.3-8.7%(V)
水溶解度 :
soluble
Merck :
14,7401
BRN :
1366
安定性::
Stable. Flammable. Hygroscopic. Incompatible with oxidizing agents.
InChIKey:
ITQTTZVARXURQS-UHFFFAOYSA-N
CAS データベース:
108-99-6(CAS DataBase Reference)
NISTの化学物質情報:
Pyridine, 3-methyl-(108-99-6)
IARC:
3 (Vol. 122) 2019
EPAの化学物質情報:
3-Methylpyridine (108-99-6)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C,Xn
Rフレーズ  10-20/21/22-34-36/37/38-22
Sフレーズ  16-26-36/37/39-45-36
RIDADR  UN 2313 3/PG 3
WGK Germany  1
RTECS 番号 TJ5000000
自然発火温度 ~1000 °F
TSCA  Yes
国連危険物分類  3
容器等級  III
HSコード  29333999
有毒物質データの 108-99-6(Hazardous Substances Data)
消防法 危-4-2-III
化審法 (5)-711
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H412 長期的影響により水生生物に有害 水生環境有害性、慢性毒性 3 P273, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P233 容器を密閉しておくこと。
P240 容器を接地すること/アースをとること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場所でのみ使用すること。
P273 環境への放出を避けること。

3-ピコリン 価格 もっと(13)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0116-1812 3-メチルピリジン 99.0+% (cGC)
3-Methylpyridine 99.0+% (cGC)
108-99-6 25mL ¥2100 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0116-1812 3-メチルピリジン 99.0+% (cGC)
3-Methylpyridine 99.0+% (cGC)
108-99-6 500mL ¥7800 2021-03-23 購入
東京化成工業 P0416 3-メチルピリジン >98.0%(GC)
3-Methylpyridine >98.0%(GC)
108-99-6 25mL ¥2000 2021-03-23 購入
東京化成工業 P0416 3-メチルピリジン >98.0%(GC)
3-Methylpyridine >98.0%(GC)
108-99-6 500mL ¥3600 2021-03-23 購入
関東化学株式会社(KANTO) 32223-00 β‐ピコリン >98.0%(GC)
β‐Picoline (β=3) >98.0%(GC)
108-99-6 500mL ¥3700 2021-03-23 購入

3-ピコリン MSDS


3-Methylpyridine

3-ピコリン 化学特性,用途語,生産方法

外観

無色~黄褐色, 澄明の液体

溶解性

水、エタノール及びアセトンに極めて溶けヤすい。

用途

医薬?農薬?有機ゴム薬品?界面活性剤の合成原料及び溶剤 (NITE CHRIP)

用途

有機合成原料(医薬品、農薬、ゴム薬品、界面活性剤)、溶剤。

使用上の注意

使用上の注意

化学的特性

colourless liquid

化学的特性

Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.

天然物の起源

3-Methylpyridine is released during the production of fossil fuels. It is formed as a byproduct of coke production (Naizer and Mashek 1974); is present in coal gasification wastewater (Giabbai et al 1985); is a contaminant of groundwater near underground coal gasification sites (Stuermer and Morris 1982); is a component of groundwater contaminated with coal-tar waste (Pereira et al 1983); and is found in shale oil wastewaters (Hawthorne and Sievers 1984; Hawthorne et al 1985). It is formed upon pyrolysis of wood (Yasuhara and Sugiura 1987) and is a constituent of cigarette (IARC 1986; Sakuma et al 1984) and marijuana (Merli et al 1981) smoke. 3-Methylpyridine is formed during the thermal degradation of nicotine in the burning of tobacco (Schmelz et al 1979). The chemical is also present in brewed coffee (Sasaki et al 1987) and black tea (Werkoff and Hubert 1975). 3-Methylpyridine has been detected along with other micropollutants in the Barcelona water supply (Rivera et al 1987). Methods for the biological treatment of wastewater high in the chemical have been developed (Roubiskova 1986). The biodegradability of 3-methylpyridine has been studied in various soils (Sims and Sommers 1985, 1986).

使用

A useful precursor to agrochemicals and antidotes for organophosphate poisoning.

使用

Solvent; intermediate in the dye and resins industries; in the manufacture of insecticides, waterproofing agents, niacin, and niacinamide.

調製方法

There are three major methods of 3-methylpyridine manufacturing: (1) vaporphase reaction of acetaldehyde and ammonia with formaldehyde and/or methanol in the presence of an acidic catalyst (e.g. Si02A103); (2) extraction from bone oil; (3) dry distillation of bones or coal (Hawley 1977; Parmeggiani 1983).

一般的な説明

Colorless liquid with a sweetish odor .

空気と水の反応

Highly Flammable. Water soluble.

反応プロフィール

3-Picoline may react with oxidizing materials . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

健康ハザード

HARMFUL if swallowed, inhaled or absorbed through skin. Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes and skin. Inhalation may be fatal as a result of spasm, inflammation of larynx and bronchi, chemical pneumonitis and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

健康ハザード

Clinical signs of intoxication caused by alkyl derivatives of pyridine including weight loss, diarrhea, weakness, ataxia and unconsciousness (RTECS 1988). Poisoning in a 32 year old male exposed to industrial vapors was characterized by unique autonomic disturbances against asthenic background (angiodystonia, tendency toward hypotonia and bradycardia, increase of pilomotor reflex, and disturbances of thermoregulation) and by polyneuritic phenomena (Budanova 1973).
A 58-year old man occupationally exposed to 3-methylpyridine for 11 years showed an increase in liver glutamic pyruvic transaminase and glutamic oxaloacetic transaminase (Caballeria et al 1979).

火災危険

Special Hazards of Combustion Products: Vapors may travel considerable distance to a source of ignition and flashback. Forms explosive mixtures in air. Emits toxic fumes under fire conditions.

工業用途

3-Methylpyridine can be used as a solvent, an intermediate in the dye and resin industries, in the manufacture of insecticides, as a waterproofing agent, in synthesis of pharmaceuticals, as rubber accelerators and a laboratory reagent (Hawley 1977; Windholz et al 1983). It is also used as a chemical intermediate for niacin and niacinamide (anti-pellagra vitamins) production. U.S. production in 1978 was estimated at 1.32-2.07xl07 kg (HSDB 1988).

安全性プロファイル

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx.

職業ばく露

(o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.

Carcinogenicity

No reliable studies in mammals to evaluate the carcinogenic potential of any of the three methylpyridines were found. None of the methylpyridines is listed as a carcinogen by IARC, NTP, OSHA, or ACGIH.

代謝

Methylpyridines can be absorbed by inhalation, ingestion and skin contact (Parmeggiana 1983). The percentage uptake of 3-methylpyridine by rats increased with dosage; elimination occurred in 2 phases, the duration of which also was dose dependent (Zharikov and Titov 1982). Addition of a methyl group to pyridine greatly increased the rate of uptake into liver, kidney and brain of rats (Zharikov et al 1983). The position of the methyl group drastically influenced the pharmacokinetics of the methylpyridines, with 3-methylpyridine exhibiting the longest biological halflife.
N-Oxidation is a minor route for 3-methylpyridine biotransformation with 6.6, 4.2, and 0.7% biotransformation of the dose, respectively, being excreted in the urine of mice, rats and guinea pigs receiving i.p. doses of the chemical (Gorrod and Damani 1980). Urinary excretion of 3-methylpyridine N-oxide was increased following pretreatment of mice with phenobarbital but 3-methylcholanthrene had no appreciable effect on N-oxide elimination (Gorrod and Damani 1979a, 1979b). The structure of 3-methylpyridine N-oxide has been verified by mass spectrometry (Cowan et al 1978).

輸送方法

UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

純化方法

In general, the same methods of purification that are described for 2-methylpyridine can be used. However, 3-methylpyridine often contains 4-methylpyridine and 2,6-lutidine, neither of which can be removed satisfactorily by drying and fractionation, or by using the ZnCl2 complex. Biddiscombe and Handley [J Chem Soc 1957 1954], after steam distillation as for 2-methylpyridine, treated the residue with urea to remove 2,6-lutidine, then azeotropically distilled with acetic acid (the azeotrope had b 114.5o/712mm), and recovered the base by adding excess of aqueous 30% NaOH, drying with solid NaOH and carefully fractionally distilling. The distillate is then fractionally crystallised by slow partial freezing. An alternative treatment [Reithoff et al. Ind Eng Chem (Anal Edn) 18 458 1946] is to reflux the crude base (500mL) for 20-24hours with a mixture of acetic anhydride (125g) and phthalic anhydride (125g) followed by distillation until phthalic anhydride begins to pass over. The distillate is treated with NaOH (250g in 1.5L of water) and then steam distilled. Addition of solid NaOH (250g) to this distillate (ca 2L) led to the separation of 3-methylpyridine which is removed, dried (K2CO3, then BaO) and fractionally distilled. (Subsequent fractional freezing would probably be advantageous.) The hydrochloride has m 85o, and the picrate has m 153o(from Me2CO, EtOH or H2O). [Beilstein 20 III/IV 2710, 20/5 V 506.]

不和合性

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

3-ピコリン 上流と下流の製品情報

原材料

準備製品


3-ピコリン 生産企業

Global( 330)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Jiangsu Zhongbang Pharmaceutical Co., Ltd.
025-87151996
025-87151996 zbsales@chinaredsun.com CHINA 32 55
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

108-99-6(3-ピコリン)キーワード:


  • 108-99-6
  • beta-Methylpyridine
  • bPicolin
  • B-Picoline
  • meta-Methylpyridine
  • m-methylpyridine
  • m-Picoline
  • pyridine,3-methyl-
  • BETA-PICOLINE
  • BETAP
  • 3-picoline (beta)
  • 3-Methylpyidine
  • 3-PICOLINE, 99.5+%
  • 3-MethylPyridine(Picoline)
  • 3-nethylpyridine
  • 3-METHYLPYRIDINE
  • 3-PICOLINE
  • 3-PICOLINE (3-METHYLPYRIDINE)
  • 3-methylpyridine,3-picoline
  • 3-Picoline ,99%
  • 3-Picoline ,98.5%
  • 3-Picoline, 99% 2.5LT
  • 3-Picoline, 99% 250ML
  • 3-Picoline, 99% 500ML
  • NSC 18251
  • 3-METHYLPYRIDINE FOR SYNTHESIS
  • 3-Methylpyridine >=99.5%
  • 3-Picoline, 99.5%(GC)
  • 3-Methylpyridine m-Picoline
  • .beta.-Methylpyridine
  • 3-methyl-pyridin
  • 3-ピコリン
  • β-ピコリン
  • 3-メチルピリジン
  • 3メチルピリジン
  • 3-ピコリン(β-〃)
  • Β‐ピコリン
Copyright 2017 © ChemicalBook. All rights reserved