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ベンゼン [アミノ酸配列分析用]

ベンゼン [アミノ酸配列分析用] 化学構造式
71-43-2
CAS番号.
71-43-2
化学名:
ベンゼン [アミノ酸配列分析用]
别名:
ベンゼン;ベンゼン (1mg/ml メタノール溶液) [水質分析用];ベンゼン [アミノ酸配列分析用];シクロヘキサトリエン;コールナフタ;フェン;ベンゾール;ピロベンゾール;1,3,5-シクロヘキサトリエン;(6)アヌレン;(1H6)ベンゼン;ベンゼン CRM4002-A;ベンゼン(脱水);ベンゼン標準原液;ベンゼンを含むゴムのりでベンゼン容量5%以上のもの;ベンゼンを含有するゴムのりで、その含有するベンゼンの容量が当該ゴムのりの溶剤(希釈剤を含む。)の5パーセントを超えるもの;ベンゼン (1mg/mLメタノール溶液) [水質分析用];ベンゼン [吸光分析用];ベンゼン(脱水) ‐SUPER‐;ベンゼン ACS REAGENT,≥99.0%
英語化学名:
Benzene
英語别名:
PHENE;Benzen;Fenzen;BENZOL;Benzeen;Benzole;Benzolo;BENZENE;Annulene;BenzeneI
CBNumber:
CB6854153
化学式:
C6H6
分子量:
78.11
MOL File:
71-43-2.mol

ベンゼン [アミノ酸配列分析用] 物理性質

融点 :
5.5 °C(lit.)
沸点 :
80 °C(lit.)
比重(密度) :
0.874 g/mL at 25 °C(lit.)
蒸気密度:
2.77 (vs air)
蒸気圧:
166 mm Hg ( 37.7 °C)
屈折率 :
n20/D 1.501(lit.)
闪点 :
12 °F
貯蔵温度 :
0-6°C
溶解性:
Miscible with alcohol, chloroform, dichloromethane, diethyl ether, acetone and acetic acid.
酸解離定数(Pka):
43(at 25℃)
外見 :
Liquid
色:
APHA: ≤10
臭い (Odor):
Paint-thinner-like odor detectable at 12 ppm
Relative polarity:
0.111
臭気閾値(Odor Threshold):
2.7ppm
爆発限界(explosive limit):
1.4-8.0%(V)
水溶解度 :
0.18 g/100 mL
極大吸収波長 (λmax):
λ: 280 nm Amax: 1.0
λ: 290 nm Amax: 0.15
λ: 300 nm Amax: 0.06
λ: 330 nm Amax: 0.02
λ: 350-400 nm Amax: 0.01
Merck :
14,1066
BRN :
969212
Henry's Law Constant:
10.4 at 45.00 °C, 11.4 at 50.00 °C, 13.3 at 55.00 °C, 14.5 at 60.00 °C, 16.8 at 65.00 °C, 19.2 at 70.00 °C (static headspace-GC, Park et al., 2004)
暴露限界値:
TLV-TWA 10 ppm (~32 mg/m3) (ACGIH and OSHA); ceiling 25 ppm (~80 mg/m3) (OSHA and MSHA); peak 50 ppm (~160 mg/m3)/10 min/8 h (OSHA); carcinogenicity: Suspected Human Carcinogen (ACGIH), Human Sufficient Evidence (IARC).
安定性::
Stable. Substances to be avoided include strong oxidizing agents, sulfuric acid, nitric acid, halogens. Highly flammable.
InChIKey:
UHOVQNZJYSORNB-UHFFFAOYSA-N
CAS データベース:
71-43-2(CAS DataBase Reference)
IARC:
1 (Vol. 29, Sup 7. 100F, 120) 2018
NISTの化学物質情報:
Benzene(71-43-2)
EPAの化学物質情報:
Benzene (71-43-2)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T
Rフレーズ  45-46-11-36/38-48/23/24/25-65-39/23/24/25-23/24/25
Sフレーズ  53-45-36/37-16-7
RIDADR  UN 1114 3/PG 2
WGK Germany  3
RTECS 番号 CY1400000
3-10
自然発火温度 560 °C
TSCA  Yes
HSコード  2902 20 00
国連危険物分類  3
容器等級  II
有毒物質データの 71-43-2(Hazardous Substances Data)
毒性 LD50 orally in young adult rats: 3.8 ml/kg (Kimura)
消防法 危険物第4類第一石油類(非水溶性)
化審法 (3)-1 優先評価化学物質
安衛法 特化則 特定化学物質(特定第2類)
PRTR法 特定第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H304 飲み込んで気道に侵入すると生命に危険のおそ れ 吸引性呼吸器有害性 1 危険
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
H340 遺伝性疾患のおそれ 生殖細胞変異原性 1A, 1B 危険
H350 発がんのおそれ 発がん性 1A, 1B 危険
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
H412 長期的影響により水生生物に有害 水生環境有害性、慢性毒性 3 P273, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P311 医師に連絡すること。
P331 無理に吐かせないこと。
P370+P378 火災の場合:消火に...を使用すること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。

ベンゼン [アミノ酸配列分析用] 価格 もっと(85)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0102-1694 ベンゼン(超脱水) 99.5+% (cGC)
Benzene, Super Dehydrated 99.5+% (cGC)
71-43-2 100mL ¥2500 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01W0102-1230 ベンゼン 99.7+% (Capillary GC)
Benzene 99.7+% (Capillary GC)
71-43-2 100mL ¥2500 2020-09-21 購入
東京化成工業 Q0038 ベンゼン [アミノ酸配列分析用] >99.5%(GC)
Benzene [Sequencing Solvent] >99.5%(GC)
71-43-2 500mL ¥2900 2018-12-04 購入
東京化成工業 B0020 ベンゼン [吸光分析用] >99.5%(GC)
Benzene [for Spectrophotometry] >99.5%(GC)
71-43-2 500mL ¥4100 2018-12-04 購入
関東化学株式会社(KANTO) 04084-01 ベンゼン >99.5%(GC)
Benzene >99.5%(GC)
71-43-2 500mL ¥1000 2018-12-13 購入

ベンゼン [アミノ酸配列分析用] 化学特性,用途語,生産方法

外観

無色澄明の液体

溶解性

水に微溶。エタノール、エーテルと混和。

用途

汎用試薬、高純度を要する溶剤等。

用途

アミノ酸配列分析における溶剤。

用途

薄層及びペーパークロマトグラフィーの展開溶媒。

用途

分解ガソリン等から抽出される芳香族炭化水素で、スチレン、フェノール、シクロヘキサン等の原料として使用される他、各種化学品の原料、溶剤等に使用されます。

用途

精密分析、超高純度溶剤としての個人専用試薬。

用途

食品及び水中等の農薬及びPCB定量における溶媒。

用途

機器及び比色分析における低バックグラウンド抽出溶媒、高純度溶剤。

用途

汎用試薬、溶剤、有機合成原料。

用途

高速液体クロマトグラフィーの溶離液及び溶離液の調製。

用途

本物質の主な用途は、純ベンゼンでは合成原料として染料、合成ゴム、合成洗剤、有機顔料、有機ゴム薬品、医薬品、香料、合成繊維(ナイロン)、合成樹脂(ポリスチレン、フェノール、ポリエステル)、食品(コハク酸、ズルチン)、農薬(2,4-D、クロルピクリンなど)、可塑剤、写真薬品、爆薬(ピクリン酸)、防虫剤(パラジクロロベンゼン)、防腐剤(PCP)、絶縁油(PCD)、熱媒、溶剤級ベンゼンでは塗料、農薬、医薬品など一般溶剤、油脂、抽出剤、石油精製など、その他アルコール変性用である

使用上の注意

不活性ガス封入

説明

Benzene is a colorless, volatile, highly flammable liquid that is used extensively in the chemical industry and received wide interest in the early days of organic chemistry.
Benzene
Because of its structure, benzene is a very stable organic compound. It does not readily undergo addition reactions. Addition reactions involving benzene require high temperature, pressure, and special catalysts. The most common reactions involving benzene involve substitution reactions. Numerous atoms and groups of atoms may replace a hydrogen atom or several hydrogen atoms in benzene. Th ree important types of substitution reactions involving benzene are alkylation, halogenation, and nitration. In alkylation, an alkyl group or groups substitute for hydrogen(s).

化学的特性

Benzene is a clear, volatile, colorless, highly flammable liquid with a pleasant, characteristic odor. It is an aromatic hydrocarbon that boils at 80.1 DC. Benzene is used as a solvent in many areas of industries, such as rubber and shoe manufacturing, and in the production of other important substances, such as styrene, phenol, and cyclohexane. It is essential in the manufacture of detergents, pesticides, solvents, and paint removers. It is present in fuels such as gasoline up to the level of 5%.

物理的性質

Clear, colorless to light yellow watery liquid with an aromatic, musty, phenolics or gasoline-like odor. At 40 °C, an odor threshold concentration of 190 μg/L in air was determined by Young et al. (1996). An odor threshold of 4.68 ppmv was determined by Leonardos et al. (1969). A detection odor threshold concentration of 108 mg/m3 (34 ppmv) was reported by Punter (1983). The average least detectable odor threshold concentrations in water at 60 °C and in air at 40 °C were 0.072 and 0.5 mg/L, respectively (Alexander et al., 1982).

天然物の起源

Detectable levels of benzene have been found in a number of soft drinks that contain either a sodium or potassium benzoate preservative and ascorbic acid, and 'diet' type products containing no added sugar are reported to be particularly likely to contain benzene at detectable levels. Surveys carried out in the USA, the UK and Canada have all confirmed that a small proportion of these products may contain low levels of benzene. For example, in a survey of 86 samples analysed by the FDA between April 2006 and March 2007, only five products were found to contain benzene at concentrations above 5 ug kg-1. The levels found were in a range from approximately 10–90 ug kg-1. A survey of 150 UK-produced soft drinks by the Food Standards Agency (FSA) published in 2006 showed that four products contained benzene at levels above 10 ug kg-1, and the highest level recorded was 28 ug kg-1. However, it has been reported that higher levels may develop in these products during prolonged storage, especially if they are exposed to daylight.
Benzene may also be formed in some mango and cranberry drinks in the absence of added preservatives, because these fruits contain natural benzoates.

来歴

Benzene was discovered in 1825 by Michael Faraday (1791–1867), who identified it in a liquid residue from heated whale oil. Faraday called the compound bicarburet of hydrogen, and its name was later changed to benzin by Eilhardt Mitscherlich (1794–1863), who isolated the compound from benzoin (C14H12O2).

使用

Benzene is also converted to cyclohexane, which is used to produce nylon and synthetic fibers.

使用

Benzene occurs in coal and coal-tar distillationproducts and in petroleum products suchas gasoline. It is also found in the gases andleachates of landfills for industrial wastes,construction debris, and landscaping refuse(Oak Ridge National Laboratory 1989). Traceamounts of benzene, toluene, xylenes, andother volatile organics have been found inthe soils and groundwaters near many sanitarylandfills (U.S. EPA 1989a,b). Kramer(1989) has assessed the level of exposuresto benzene during removal, cleaning, pumping,and testing of underground gasoline storagetanks. The average human exposureswere 0.43–3.84 ppm (in 1.5–6 hours) and thehighest short-term (15–minute) exposure was9.14 ppm. Benzene also occurs in the tobaccosmoke (Hoffmann et al. 1989); thus the riskof its exposure may enhance from inhalingsuch smoke.
Benzene is used as a solvent for waxes,resins, and oils; as a paint remover; as a diluentfor lacquers; in the manufacture of dyes,pharmaceuticals, varnishes, and linoleum;and as a raw material to produce a numberof organic compounds.

使用

Manufacturing of ethylbenzene (for styrene monomer), dodecylbenzene (for detergents), cyclo- hexane (for nylon), phenol, nitrobenzene (for ani- line), maleic anhydride, chlorobenzene, diphenyl, benzene hexachloride, benzene-sulfonic acid, and as a solvent.

使用

Benzene is also known as benzol, benzole, coal tar naphtha, and phenyl hydride, benzene is a clear, colorless, flammable liquid made by passing coke gas through oil, which is then distilled to produce benzene and toluol. The benzene is separated from the toluol by fractional distillation. Benzene is soluble in alcohol, ether, chloroform, and glacial acetic acid, but it is insoluble in water. Benzene was used as a solvent for many photographic operations in the 19th century. In the collodion process, benzene was used to dissolve rubber to both subcoat and supercoat negatives. It was also used as a solvent for Canada balsam in the Cutting method of sealing ambrotypes and cementing lens elements. Benzene was also used as a solvent for wax, gums, resins, and amber and in particular for retouching varnishes applied to silver bromide gelatin negatives.

調製方法

Today benzene, which is a natural component of petroleum, is obtained from petroleum by several processes. Toluene hydrodealkylation involves mixing toluene (C6H5CH3) and hydrogen in the presence of catalysts and temperatures of approximately 500°C and pressures of about 50 atmospheres to produce benzene and methane: C6H5CH3 + H2 → C6H6 + CH4. Hydrodealkylation strips the methyl group from toluene to produce benzene. Toluene disproportionation involves combining toluene so that the methyl groups bond to one aromatic ring, producing benzene and xylene. Benzene can also be obtained from petroleum reforming in which temperature, pressure, and catalysts are used to convert petroleum components to benzene, which can then be extracted using solvents and distillation processes. Another source of benzene is pyrolysis gasoline or pygas.

定義

ChEBI: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.

反応性

Benzene reacts (1) with chlorine, to form (a) substitution products (one-half of the chlorine forms hydrogen chloride) such as chlorobenzene, C6H5Cl; dichlorobenzene, C6H4Cl2(1,4) and (1,2); trichlorobenzene, C6H3Cl3(1,2,4); tetrachlorobenzene (1,2,3,5); and (b) addition products, such as benzene dichloride C6H6Cl2; benzene tetrachloride, C6H6Cl4; and benzene hexachloride, C6H6Cl6. The formation of substitution products of the benzene nucleus, whether in benzene or its homologues, is favored by the presence of a catalyzer, e.g., iodine, phosphorus, iron; (2) with concentrated HNO3, to form nitrobenzene, C6H5NO2; 1,3- dinitrobenzene, C6H4(NO2)2 (1,3), 1,3,5-trinitrobenzene, C6H3(NO2)3 (1,3,5); (3) with concentrated H2SO4, to form benzene sulfonic acid, C6H5SO3H, benzene disulfonic acid, C6H4(SO3H)2(1,3), benzene trisulfonic acid, C6H3(SO3H)3 (1,3–5); (4) with methyl chloride plus anhydrous aluminum chloride (Friedel-Crafts reaction) to form toluene, monomethyl benzene, C6H5CH3; dimethyl benzene C6H4(CH3)2; trimethyl benzene, C6H3(CH3)3; (5) with acetyl chloride plus anhydrous aluminum chloride (Friedel-Crafts reaction) to form acetophenone (methylphenyl ketone), C6H5COCH3.

一般的な説明

A clear colorless liquid with a petroleum-like odor. Flash point less than 0°F. Less dense than water and slightly soluble in water. Hence floats on water. Vapors are heavier than air.

空気と水の反応

Highly flammable. Slightly soluble in water.

反応プロフィール

Benzene reacts vigorously with allyl chloride or other alkyl halides even at minus 70°C in the presence of ethyl aluminum dichloride or ethyl aluminum sesquichloride. Explosions have been reported [NFPA 491M 1991]. Ignites in contact with powdered chromic anhydride [Mellor 11:235 1946-47]. Incompatible with oxidizing agents such as nitric acid. Mixtures with bromine trifluoride, bromine pentafluoride, iodine pentafluoride, iodine heptafluoride and other interhalogens can ignite upon heating [Bretherick 5th ed. 1995]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.). The reaction of Benzene and trichloroacetonitrile evolves toxic chloroform and HCl gasses. (Hagedorn, F., H.-P. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).

危険性

The acute toxicity of benzene is low. Inhalation of benzene can cause dizziness, euphoria, giddiness, headache, nausea, drowsiness, and weakness. Benzene can cause moderate irritation to skin and severe irritation to eyes and mucous membranes. Benzene readily penetrates the skin to cause the same toxic effects as inhalation or ingestion. The chronic toxicity of benzene is significant. Exposure to benzene affects the blood and blood-forming organs such as the bone marrow, causing irreversible injury; blood disorders including anemia and leukemia may result. The symptoms of chronic benzene exposure may include fatigue, nervousness, irritability, blurred vision, and labored breathing. Benzene is regulated by OSHA as a carcinogen (Standard 1910.1028) and is listed in IARC Group 1 ("carcinogenic to humans"). This substance is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard.

健康ハザード

Benzene is an acute as well as a chronictoxicant. The acute toxic effects from inhalation,ingestion, and skin contact are low tomoderate. The symptoms in humans are hallucination,distorted perception, euphoria, somnolence,nausea, vomiting, and headache. Thenarcotic effects in humans may occur frominhaling benzene in air at a concentrationof 200 ppm. High concentrations may cause convulsions. A 5- to 10-minute exposure to2% benzene in air may be fatal. Death mayresult from respiratory failure.
Benzene is an irritant to the eyes, nose,and respiratory tract. The chronic poisoningfrom benzene is much more severe than itsacute toxicity. The target organs to acuteand chronic poisoning are the blood, bonemarrow, central nervous system, respiratorysystem, eyes, and skin. Heavy occupationalexposures to benzene can cause bone marrowdepression and anemia, and in rare cases,leukemia. Leukemia may develop severalyears after the exposure ceases. Deaths fromleukemia, attributed to occupational exposureto benzene in the workplace, which may beon the order of 200 ppm concentration, havebeen documented (ACGIH 1986). Benzene islisted as a suspected human carcinogen. Inaddition to leukemia, malignant lymphoma,and myeloma, lung cancer in subjects exposedto benzene has been reported (Aksoy 1989).
Absorption of liquid benzene through theskin may be harmful. The main eliminationpathway for benzene absorbed throughinhalation or skin contact is metabolism.Hydroxyl radicals play an important role inthe process of metabolism. Khan and coworkers(1990) have reported the formationof formaldehyde and degradation of deoxyribose,suggesting the generation of hydroxylradicals during benzene toxicity to the bonemarrow S-9 fraction. The hydroxyl radicalsreact with benzene to form phenols and dihydroxyphenols,which are excreted rapidly inurine. About one-third of the retained benzeneis excreted as phenols in the urine. Theremaining two-thirds may be further degradedand attached onto the tissue or oxidized andexhaled as CO2.
Kalf and associates (1989) have investigatedthe action of prostaglandin H synthasein benzene toxicity and preventionof benzene-induced myelo- and genotoxicityby nonsteroidal anti-inflammatory drugs(NSAIDs). Indomethacin, a prostaglandin Hsynthase inhibitor prevented the dose- dependentbone marrow depression and increase in marrow prostaglandin E level in mice intravenouslydosed with benzene. Indomethacin,aspirin, or meclofenamate prevented thedecrease in cellularity and increase in micronucleatedpolychromatic erythrocytes in peripheralblood, caused by intravenous injectionof benzene (100–1000 mg/kg) in mice.

燃焼性と爆発性

Benzene is a highly flammable liquid (NFPA rating = 3), and its vapors may travel a considerable distance to a source of ignition and "flash back." Vapor-air mixtures are explosive above the flash point. Carbon dioxide and dry chemical extinguishers should be used to fight benzene fires.

化学反応性

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

工業用途

Benzene (C6H6, CAS No. 71-43-2) is an aromatic hydrocarbon compound used extensively in the chemical industry as an intermediate in the manufacture of polymers and other products. It is also a common atmospheric contaminant and is present in motor vehicle exhaust emissions and cigarette smoke.
In 1990, it was discovered by the USA soft drinks industry that benzene could be produced at low levels in certain soft drinks containing a benzoate preservative and ascorbic acid. Since benzene is a known human carcinogen, its presence in food and beverages is clearly undesirable.

安全性プロファイル

Confirmed human carcinogen producing myeloid leukemia, Hodgkin's dsease, and lymphomas by inhalation. Experimental carcinogenic, neoplastigenic, and tumorigenic data. A human poison by inhalation. An experimental poison by skin contact, intraperitoneal, intravenous, and possibly other routes. Moderately toxic by ingestion and subcutaneous routes. A severe eye and moderate sktn irritant. Human systemic effects by inhalation and ingestion: blood changes, increased body temperature. Experimental teratogenic and reproductive effects. Human mutation data reported. A narcotic. In industry, inhalation is the primary route of chronic benzene poisoning. Poisoning by skin contact has been reported. Recent (1 987) research indicates that effects are seen at less than 1 ppm. Exposures needed to be reduced to 0.1 ppm before no toxic effects were observed. Elimination is chiefly through the lungs.

職業ばく露

Benzene is used as a constituent in motor fuels; as a solvent for fats; inks, oils, paints, plastics, and rubber, in the extraction of oils from seeds and nuts; in photogravure printing. It is also used as a chemical intermediate. By alkylation, chlorination, nitration, and sulfonation, chemicals, such as styrene, phenols, and malefic anhydride are produced. Benzene is also used in the manufacture of detergents, explosives, pharmaceuticals; in the manufacture of cyclohexane and ethylbenzene; and dye-stuffs. Increased concern for benzene as a significant environmental pollutant arises from public exposure to the presence of benzene in gasoline and the increased content in gasoline due to requirements for unleaded fuels for automobiles equipped with catalytic exhaust converters.

Carcinogenicity

Benzene is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

環境運命予測

Benzene is released to air primarily by vaporization and combustion emissions associated with its use in gasoline. Other sources are vapors from its production and use in manufacturing other chemicals. In addition, benzene may be in industrial effluents discharged into water and accidental releases from gas and oil production, refining and distribution industries. Benzene released to soil will either evaporate very quickly or leach to groundwater. It can be biodegraded by soil and groundwater microbes. Benzene released to surface water should mostly evaporate within a few hours to a few days, depending on quantity, temperature, water turbulence, etc. Although benzene does not degrade by hydrolysis, it may be biodegraded by microbes.

貯蔵

work with benzene should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. Benzene should be used only in areas free of ignition sources.

輸送方法

UN1114 Benzene, Hazard Class: 3; Labels: 3— Flammable liquid

純化方法

For most purposes, *benzene can be purified sufficiently by shaking with conc H2SO4 until free from thiophene, then with H2O, dilute NaOH and water, followed by drying (with P2O5, sodium, LiAlH4, CaH2, 4X Linde molecular sieve, or CaSO4, or by passage through a column of silica gel, and for a preliminary drying, CaCl2 is suitable), and distillation. A further purification step to remove thiophene, acetic acid and propionic acid, is crystallisation by partial freezing. The usual contaminants in dry thiophene-free *benzene are non-benzenoid hydrocarbons such as cyclohexane, methylcyclohexane, and heptanes, together with naphthenic hydrocarbons and traces of toluene. Carbonyl-containing impurities can be removed by percolation through a Celite column impregnated with 2,4-dinitrophenylhydrazine, phosphoric acid and H2O. (Prepared by dissolving 0.5g DNPH in 6mL of 85% H3PO4 by grinding together, then adding and mixing 4mL of distilled H2O and 10g Celite.) [Schwartz & Parker Anal Chem 33 1396 1961.] *Benzene has been freed from thiophene by refluxing with 10% (w/v) of Raney nickel for 15minutes, after which the nickel is removed by filtration or centrifugation. Dry *benzene is obtained by doubly distilling high purity *benzene from a solution containing the blue ketyl formed by the reaction of sodium-potassium alloy with a small amount of benzophenone. Thiophene has been removed from *benzene (absence of bluish-green coloration when 3mL of *benzene is shaken with a solution of 10mg of isatin in 10mL of conc H2SO4) by refluxing the *benzene (1.25L) for several hours with 40g HgO (freshly precipitated) dissolved in 40mL glacial acetic acid and 300mL of water. The precipitate is filtered off, the aqueous phase is removed and the *benzene is washed twice with H2O, dried and distilled. Alternatively, *benzene dried with CaCl2 has been shaken vigorously for 0.5hour with anhydrous AlCl3 (12g/L) at 25-35o, then decanted, washed with 10% NaOH, and water, dried and distilled. The process is repeated, giving thiophene-free *benzene. [Holmes & Beeman Ind Eng Chem 26 172 1934.] After shaking successively for about an hour with conc H2SO4, distilled water (twice), 6M NaOH, and distilled water (twice), *benzene is distilled through a 3-ft glass column to remove most of the water. Absolute EtOH is added and the *benzene-alcohol azeotrope is distilled. (This low-boiling distillation leaves any non-azeotrope-forming impurities behind.) The middle fraction is shaken with distilled water to remove EtOH, and again redistilled. Final slow and very careful fractional distillation from sodium, then LiAlH4 under N2, removed traces of water and peroxides. [Peebles et al. J Am Chem Soc 82 2780 1960.] *Benzene liquid and vapour are very TOXIC and HIGHLY FLAMMABLE, and all operations should be carried out in an efficient fume cupboard and in the absence of naked flames in the vicinity. [Beilstein 5 H 175, 5 I 95, 5 II 119, 5 III 469.] Rapid purification: To dry benzene, alumina, CaH2 or 4A molecular sieves (3% w/v) may be used (dry for 6hours). Then benzene is distilled, discarding the first 5% of distillate, and stored over molecular sieves (3A, 4A) or Na wire.

不和合性

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, many fluorides and perchlorates, nitric acid.

廃棄物の処理

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Dilution with alcohol or acetone to minimize smoke is recommended. Bacterial degradation is also possible.

法令条例

Current USA and EU legislation does not set maximum limits for benzene in soft drinks. However, the FDA has adopted the Environmental Protection Agency (EPA) maximum contaminant level (MCL) for drinking water of 5 ppb as a quality standard for bottled water. ThisMCL has been used to evaluate the significance of benzene contamination in the soft drinks tested in surveys. The FSA has used the World Health Organization (WHO) guideline level for benzene in water of 10 mg kg-1 as a point of reference for its own survey results.

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71-43-2(ベンゼン [アミノ酸配列分析用])キーワード:


  • 71-43-2
  • Benzene, OMniSolv(R)
  • Benzene, PestiSolv(R)
  • Benzol,HPLC Grade
  • Benzene, for spectroscopy
  • Benzene, SuperDry, J&KSeal
  • Benzene, 99%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal
  • (6)annulene
  • [6]Annulene
  • ai3-00808
  • Annulene
  • Benzeen
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  • benzen(polish)
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  • benzin(obs.)
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  • bicarburetofhydrogen
  • Carbon oil
  • carbonoil
  • caswellno077
  • Coal naphtha
  • Coalnaphtha
  • epapesticidechemicalcode008801
  • Fenzen
  • ベンゼン
  • ベンゼン (1mg/ml メタノール溶液) [水質分析用]
  • ベンゼン [アミノ酸配列分析用]
  • シクロヘキサトリエン
  • コールナフタ
  • フェン
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  • 1,3,5-シクロヘキサトリエン
  • (6)アヌレン
  • (1H6)ベンゼン
  • ベンゼン CRM4002-A
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  • ベンゼンを含むゴムのりでベンゼン容量5%以上のもの
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  • ベンゼン (1mg/mLメタノール溶液) [水質分析用]
  • ベンゼン [吸光分析用]
  • ベンゼン(脱水) ‐SUPER‐
  • ベンゼン ACS REAGENT,≥99.0%
  • ベンゼン 5000
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  • ベンゼン 5,000
  • ベンゼン300
  • ベンゼン 溶液
  • ベンゼン, 0.2 mg/mL in Methanol
  • ベンゼン, 2.0 mg/mL in MeOH
  • 標準溶液 (VOC)
  • 分析化学
  • 溶剤 (HPLC用/吸収スペクトル測定用)
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