ゾルピデム

ゾルピデム 化学特性,用途語,生産方法

効能

催眠鎮静薬

説明

Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.

化学的特性

Off-White Solid

使用

A selective benzodiazepine receptor agonist not related chemically to benzodiazepines

定義

ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

一般的な説明

Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.

ゾルピデム 上流と下流の製品情報

原材料

準備製品

82626-48-0(ゾルピデム)キーワード:

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• 82626-48-0
• ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
• N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
• 6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
• N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
• 6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
• 2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
• 2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
• N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
• N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
• SL-80.0750
• N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE
• N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE HEMITARTRATE
• N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIMIDINE-3-ACETAMIDE
• ZOLPIDEM
• Ivadal
• N，N，6-Trimethyl-2-(4-methylphenyl)imidazo[1，2-α]pyridine-3-acetamide
• Niotal
• SL-80．0750-23N
• Stilnoct：Stilnox
• Zoipidem
• N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
• N,N-Dimethyl-2-[6-methyl-2-p-tolylimidazo[1,2-a]pyridine-3-yl]acetamide
• Zolpidem tatrate
• 2-(1,2,6-Trimethyl-1H-indol-3-yl)ethylamine
• N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]ethanamide
• Zolpidem CIV (10 mg)
• N,N,6-triMethyl-2-(4-Methylphenyl)iMidazo[1,2-a]-pyrid
• Edluar
• Imidazo[1,2-a]pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-
• Zolpidem solution
• N,N,6-トリメチル-2-(4-メチルフェニル)イミダゾ[1,2-a]ピリジン-3-アセトアミド
• ゾルピデム
• N,N-ジメチル-2-[6-メチル-2-p-トリルイミダゾ[1,2-a]ピリジン-3-イル]アセトアミド
• N,N-ジメチル-2-[6-メチル-2-(4-メチルフェニル)イミダゾ[1,2-a]ピリジン-3-イル]アセトアミド
• N,N-ジメチル-2-(p-トリル)-6-メチルイミダゾ[1,2-a]ピリジン-3-アセトアミド
• 2-(p-メチルフェニル)-6-メチルイミダゾ[1,2-a]ピリジン3-(1-(ジメチルアミノ)アセトアルデヒド)
• 催眠鎮静薬