チラミン 塩酸塩 化学特性,用途語,生産方法
外観
白色～うすい褐色、結晶性粉末～粉末
溶解性
エタノール及び水に溶け、アセトンにほとんど溶けない。
使用上の注意
不活性ガス封入
化学的特性
Off-White to Light Yellow Powder
天然物の起源
Tyramine was originally a compound isolated from ergot alkaloids and decaying animal tissue. It has pharmacological effects such as increasing blood pressure and exciting the uterus.
使用
Tyramine hydrochloride is a sympathomimetic, the hydrochloride salt of the naturally-occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent but cannot cross the blood-brain barrier. Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.
主な応用
Tyramine hydrochloride (T-HCl) is a kind of fluorogenic substrate of peroxidase. It is a naturally occurring monoamine derived from tyrosine. Tyramine Hydrochloride has been used:
coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure.
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis.
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification.
Neurotransmitter.
合成
Tyramine [2-(p-hydroxyphenyl) ethylamine], a significant metabolite of tyrosine, enzymatic synthesis of tyramine was established by two-step biocatalytic reaction. Firstly, l-tyrosine was prepared from raw pyruvate fermentation broth under the catalysis of TPL. Pyruvate fermentation broth was simply centrifuged, and then the supernatant was diluted and used as substrate to produce l-tyrosine. Secondly, l-tyrosine was collected as starting material to synthesize tyramine by immobilized TDC cells from Lactobacillus brevis. Pyridoxal phosphate was the common coenzyme for these two enzymes.
純化方法
Crystallise the hydrochloride from EtOH by addition of diethyl ether, or from conc HCl. [Beilstein 3 II 355.]
チラミン 塩酸塩 上流と下流の製品情報
原材料
準備製品