dl-メントール 化学特性,用途語,生産方法
外観
白色/無色～ほとんど白色/ほとんど無色粉末～塊～透明液体
定義
本品は、次の化学式で表されるテルペンアルコールである。
化粧品の成分用途
変性剤、口腔衛生剤、皮膚コンディショニング剤、外用鎮痛剤、香料、香味剤
効能
芳香・矯臭・矯味剤
説明
Menthol has a mint-like odor and a fresh, cooling taste. It may be
prepared by hydrogenation of thymol.
化学的特性
colorless to white crystalline solid
物理的性質
Appearance: colorless or white acicular prismatic crystals or white crystalline powder. Solubility: easily dissolved in ethanol, chloroform, ether, liquid paraffin, or
volatile oil and soluble in water. Odor: a cool, refreshing, and pleasant mint aroma,
sweet odor, and taste cool early after burning. Boiling point: 212?°C. Melting point:
41–43?°C. Specific optical rotation: ?49 to ?50°.
天然物の起源
Reported found in peppermint and other mint oils (e.g., M. arvensis), lemon peel oil, cranberry, pineapple, cab bage, thymus, egg, rum, cocoa, tea, honey, avocado, coriander, mango, rice, litchi, dill herb, calamus, juniper berries, fennel, buchu
oil, clam and Roman chamomile oil, Mentha species.
来歴
In the world of aromatic chemicals, menthol is often described as a unique source
of skin and mucous membranes. Menthol is mainly extracted from natural plants.
The vast majority of natural menthol in the global market is extracted from numerous Asian mint. In 2006, the world’s natural menthol production is 12,800?tons or
more. However, due to various factors, the production of natural menthol is becoming less and less. Since the 1960s, Japan, Germany, and other countries had developed the synthetic menthol products. In 1974 the German company Symrise and
Japan Takasago Fluidic Systems company launched chemical synthesis of menthol.
At present, attention has been paid to the study of menthol analogy substances and
the effect of the changes of molecular structure on the aroma and cool sensation.
Some studies have shown that hydroxyl groups located in the branched or 1, 4 chain
cannot show a sense of cool. The researchers believed that menthol analogy substances with optical activity should be able to show different, surprising cooling
effect, and the structure of hydroxyl alkyl groups is the key point to have a cooling
effect. The Japanese chemist Ryoji Noyo and his colleagues found that in
BINAP and rhodium complexes as catalysts for asymmetric hydrogenation reaction, the synthesis of menthol is very effective. Because of the contribution of asymmetric organic synthesis, they won the 2001 Nobel Prize in Chemistry.
使用
DL-Menthol may be used as an extraction solvent for the determination of parabens in food products, cosmetics and pharmaceuticals using liquid-liquid microextraction with high performance liquid chromatography-diode array detection (HPLC-DAD). It may also be used for the preparation of hydrophobic deep eutectic solvent (DES) in the extraction and determination of methylparaben, propylparaben, and butylparaben from cosmetics samples using syringe-to-syringe dispersive magnetic nanofluid microextraction procedure (SS-DMNF-ME) with high-performance liquid chromatography technique (HPLC).
製造方法
By hydrogenation of thymol.
適応症
For external application, it is applied locally and often used to relieve pain and itching. A nasal drip is used in the head cold. Inhalation or spray is used for sore throat.
Oral administration can promote digestion.
一般的な説明
White crystalline solid with a peppermint odor and taste.
空気と水の反応
Insoluble in water.
反応プロフィール
DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.
危険性
Irritant to mucous membranes on inhalation.
火災危険
DL-Menthol is combustible.
臨床応用
It can be clinically used to assist anesthesia, postoperative analgesia, intercostal
nerve block, trigeminal nerve block, occipital nerve block, and so on. When applied
locally, it can promote blood circulation, diminish inflammation, relieve itching,
relieve pain, relieve edema, and so on.
安全性プロファイル
Poison by intravenous
route. Moderately toxic by ingestion and
intraperitoneal routes. A severe eye irritant.
Incompatible with phenol, p-naphthol,
resorcinol or thymol in trituration,
potassium permanganate, chromium
trioxide, pyrogallol. Combustible liquid.
\When heated to decomposition it emits
acrid smoke and irritating fumes.
dl-メントール 上流と下流の製品情報
原材料
準備製品