チクロピジン
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- CAS番号.
- 55142-85-3
- 化学名:
- チクロピジン
- 别名:
- 5-(o-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン;5-[(2-クロロフェニル)メチル]-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン;チクロピジン;チクリド;5-(2-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン;5-[(2-クロロフェニル)メチル]-4H,5H,6H,7H-チエノ[3,2-c]ピリジン
- 英語名:
- Ticlopidine
- 英語别名:
- pcr5332;PCR 5332;Ticlosin;Anagregal;Caudaline;TICIOPIDINE;TICLOPIDINE;5-(2-Chlorobenzyl);Ticlopidine USP/EP/BP;Ticlopidine hydrochloride CRS
- CBNumber:
- CB7674370
- 化学式:
- C14H14ClNS
- 分子量:
- 263.79
- MOL File:
- 55142-85-3.mol
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チクロピジン 物理性質
- 融点 :
- 210-212 °C
- 沸点 :
- 117-120 °C(Press: 0.5 Torr)
- 比重(密度) :
- 1.273±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C(protect from light)
- 溶解性:
- クロロホルム（微量）、DMSO（微量）、メタノール（微量）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 7.10±0.20(Predicted)
- 色:
- オフホワイト～淡黄色 オイル～低融点
- CAS データベース:
- 55142-85-3(CAS DataBase Reference)
- NISTの化学物質情報:
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-(55142-85-3)
- EPAの化学物質情報:
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro- (55142-85-3)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01FLC320160 |
5-(2-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン
5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine |
55142-85-3 |
250mg |
￥95600 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC320160 |
5-(2-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン
5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine |
55142-85-3 |
1g |
￥280500 |
2018-12-26 |
購入 |
チクロピジン 化学特性,用途語,生産方法
効能
抗凝固薬, 血小板凝集抑制薬, P2Y12拮抗薬
使用
Ticlopidine suppresses aggregation of thrombocytes and possesses antiaggregant activity. It is
believed that its action is connected to its effect on thrombocyte membranes and the reduction
in quantity of released adenosine diphosphate and serotonin, which facilitate aggregation of
thrombocytes. In wide-ranging clinical trials, ticlopidine presented a number of advantages
compared to aspirin.
定義
ChEBI: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
世界保健機関（WHO）
Ticlopidine, an inhibitor of platelet aggregation, was introduced in
1978 for use as an antithrombotic agent. By 1982 its use had been associated with
cases of agranulocytosis, severe leucopenia and impaired haemostasis. The drug
remains available in most countries in which it was approved with appropriate
warnings in the product information.
一般的な説明
Ticlopidine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c]pyridine hydrochloride(Ticlid), is useful in reducing cardiac events in patients withunstable angina and cerebrovascular events in secondaryprevention of stroke. It belongs to the thienopyridine classand facilitated the development of clopidogrel. One of thedrawbacks to this agent is its side effect profile, whichincludes neutropenia, and patients receiving this antithromboticshould have their blood levels monitored. Its mechanismof action is similar to that of clopidogrel, in that itinhibits the purinergic receptors on platelets.
チクロピジン 上流と下流の製品情報
原材料
準備製品
チクロピジン 生産企業
Global( 95)Suppliers
55142-85-3(チクロピジン)キーワード:
- 55142-85-3
- 2-c)pyridine,4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-thieno(
- 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
- 5-(O-Chlorobenzyl)-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine
- PCR 5332
- pcr5332
- Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-
- 5-(2-CHLORO-BENZYL)-4,5,6,7-TETRAHYDRO-THIENO[3,2-C]PYRIDINE
- TICLOPIDINE
- TICIOPIDINE
- Ticlopidine (base and/or unspecified salts)
- 2-[N-Methyl-N-(2-chlorobenzyl)aMinoethyl]thiophene
- Ticlopidine IMpurity (N-Methyl)
- 5-(2-Chlorobenzyl)
- Anagregal
- Caudaline
- Ticlosin
- Ticlopidine hydrochloride CRS
- Ticlopidine USP/EP/BP
- 5-(o-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン
- 5-[(2-クロロフェニル)メチル]-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン
- チクロピジン
- チクリド
- 5-(2-クロロベンジル)-4,5,6,7-テトラヒドロチエノ[3,2-c]ピリジン
- 5-[(2-クロロフェニル)メチル]-4H,5H,6H,7H-チエノ[3,2-c]ピリジン
- 抗凝固薬
- 血小板凝集阻害薬