ブリバラセタム 化学特性,用途語,生産方法
効能
抗けいれん薬, 疼痛治療
説明
Brivaracetam, a novel oral
antiepileptic drug with a high affinity for synaptic vesicle
protein 2A (SV2A), was approved in Europe and the US as an
adjunctive therapy for the treatment of partial onset seizures
with or without secondary generalization in patients aged 16 or
older.42 Brivaracetam is very closely related to levetiracetam, an
antiepileptic treatment whose immediate release formulation
has been available in the United States as a generic drug since
2008, but whose extended release formulation is under patent
protection until 2028. The two drugs, which were both
developed by UCB Pharma, are structurally similar with
brivaracetam having an n-propyl group at the C-4 position of
the pyrrolidinone ring and levetiracetam having a hydrogen at
this same position. A systematic investigation of the various
substitutions of levetiracetam resulted in the identification of
more potent and selective SV2A ligands and ultimately
culminated in the discovery of brivaracetam, which has greater
affinity for SV2A, improved selectivity, more rapid brain
penetration, and faster onset of action against seizures than
levetiracetam.
使用
Treatment ofTreatment of
epilepsy, neuropathic pain and essential tremor.
定義
ChEBI: A non-proteinogenic amino acid derivative that is butanamide in which the pro-S hydrogen at position 2 is replaced by a (4R)-2-oxo-4-propylpyrrolidin-1-yl. Used for treatment of partial onset seizures related
to epilepsy.
副作用
Common side effects of brivaracetam include: constipation, nausea, vomiting, extreme tiredness or low energy. Serious side effects that may be caused include: swelling of the face, throat, tongue, lips, and eyes; difficulty swallowing or breathing; hoarseness, hallucinations (seeing things or hearing sounds that are not there), and delusions (strange thoughts or beliefs that have no basis in reality). An overdose may cause: drowsiness, extreme tiredness, dizziness, difficulty maintaining balance, blurred or double vision, slowed heartbeat, nausea, and feeling anxious.
ブリバラセタム 上流と下流の製品情報
原材料
準備製品