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りん酸水素カルシウム·2水和物

りん酸水素カルシウム·2水和物 化学構造式
7789-77-7
CAS番号.
7789-77-7
化学名:
りん酸水素カルシウム·2水和物
别名:
りん酸水素カルシウム二水和物;りん酸水素カルシウム·2水和物;りん酸カルシウム二水和物,第二;リン酸2CA二水和物;リン酸水素カルシウム二水和;りん酸一水素カルシウム,2水和物;りん酸二カルシウム二水和物;リン酸一水素カルシウム;リン酸水素カルシウム水和物「製造専用」;リン酸カルシウム, 二塩基酸 二水和物;リン酸水素カルシウム 二水和物;リン酸水素カルシウム水和物;リン酸水素カルシウム水和物 (JP17)
英語化学名:
DICALCIUM PHOSPHATE DIHYDRATE
英語别名:
DiTab;Di-tab;Bekapress D 2;CALCIUM PHOSPH;DICALCIUM PHOSPHAT;BicalciuM phosphate;Calcium phosphate di;dicalciurn phosphate;calcium phosphate,secondary;Calciumhydrogenphosphate,dih
CBNumber:
CB9439551
化学式:
CaH5O6P
分子量:
172.09
MOL File:
7789-77-7.mol

りん酸水素カルシウム·2水和物 物理性質

融点 :
109°C -H₂O
比重(密度) :
2.31
貯蔵温度 :
Inert atmosphere,Room Temperature
溶解性:
Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
外見 :
Solid
色:
White to almost white
水溶解度 :
Slightly soluble in water. Soluble in dilute hydrochloric, nitric, and acetic acid. Insoluble in alcohol
安定性::
Stable. Incompatible with acids.
InChIKey:
XAAHAAMILDNBPS-UHFFFAOYSA-L
CAS データベース:
7789-77-7(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36
WGK Germany  1
TSCA  Yes
HSコード  28352590
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

りん酸水素カルシウム·2水和物 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0104-2946 リン酸水素カルシウム水和物「製造専用」 98.0~105.0% (Titration)
Dibasic Calcium Phosphate Hydrate 98.0~105.0% (Titration)
7789-77-7 500g ¥4200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0103-1991 りん酸水素カルシウム二水和物 98.0+%
Calcium Hydrogenphosphate Dihydrate 98.0+%
7789-77-7 500g ¥2550 2021-03-23 購入
関東化学株式会社(KANTO) 07091-01 りん酸水素カルシウム二水和物 >98.0%(T)
Calcium hydrogenphosphate dihydrate >98.0%(T)
7789-77-7 500g ¥9500 2021-03-23 購入
関東化学株式会社(KANTO) 07091-00 りん酸水素カルシウム二水和物 >98.0%(T)
Calcium hydrogenphosphate dihydrate >98.0%(T)
7789-77-7 500g ¥10500 2021-03-23 購入
Sigma-Aldrich Japan 307653 リン酸水素カルシウム 二水和物 98%
Calcium hydrogenphosphate dihydrate 98%
7789-77-7 500g ¥8620 2021-03-23 購入

りん酸水素カルシウム·2水和物 MSDS


Calcium hydrogenphosphate dihydrate

りん酸水素カルシウム·2水和物 化学特性,用途語,生産方法

外観

白色の結晶性粉末

定義

本品は、リン酸2Ca(*)の水和物であり、次の化学式で表される。
参照表示名称:リン酸2Ca

溶解性

水又はエタノール(99.5)にほとんど溶けない。希塩酸又は希硝酸に溶ける。

用途

医薬品、製剤原料。

用途

医薬品及び動物飼料原料。

化粧品の成分用途

不透明化剤、口腔ケア剤、研磨.スクラブ剤

効能

カルシウム補充薬, 賦形剤

商品名

リン酸水素カルシウム (三恵薬品); リン酸水素カルシウム (日興製薬); リン酸水素カルシウム水和物 (吉田製薬); リン酸水素カルシウム水和物 (日興製薬); 第二リン灰 (山善製薬)

化学的特性

Dibasic calcium phosphate dihydrate is a white, odorless, tasteless powder or crystalline solid. It occurs as monoclinic crystals.

化学的特性

white crystalline solid

使用

Replenisher (calcium); pharmaceutic aid (tablet base).

使用

Dicalcium Phosphate, Dihydrate is a source of calcium and phosphorus that also functions as a dough conditioner and bleaching agent. It functions as a dough conditioner in bakery products, as a bleaching agent in flour, as a source of calcium and phosphorus in cereal products, and as a source of calcium for alginate gels. It contains approximately 23% calcium. It is practically insoluble in water. It is also termed dibasic calcium phosphate, dihydrate and calcium phosphate dibasic, hydrous. It is used in dessert gels, baked goods, cereals, and breakfast cereals.

使用

Dicalcium phosphate dihydrate is only slightly soluble at ordinary temperatures of mixing and holding doughs and batters. As a result, it does not release acidity for reaction with soda until late in the baking stage, when the temperature reaches 135 to 140°F. Since DCP·2H20 does not begin to react below 135°F, and the interior structure of a baked product begins to firm at about 160°F, a product that bakes rapidly may not provide sufficient time for complete release of all the C02. DCP·2H2 0, therefore, cannot be used in biscuits, pancakes or any baked product that is completely baked in less than 20 min.
Dicalcium phosphate dihydrate is seldom used by itself in leavening systems but is usually combined with fasterreacting acidic phosphates. Its major applications are in cake mixes, frozen bread doughs, and other products requiring a half hour or more to complete baking. It has a low neutralizing value, and therefore more DCP·2H20 is required to neutralize a given amount of soda than for other phosphate-leavening acids.

調製方法

Calcium phosphates are usually manufactured by reacting very pure phosphoric acid with calcium hydroxide, Ca(OH)2 obtained from limestone, in stoichiometric ratio in aqueous suspension followed by drying at a temperature that will allow the correct hydration state to be achieved. After drying, the coarse-grade material is obtained by means of a classification unit; the fine particle-size material is obtained by milling.

brand name

CalStar (FMC); D.C.P. (Parke-Davis).

応用例(製薬)

Dibasic calcium phosphate dihydrate is widely used in tablet formulations both as an excipient and as a source of calcium and phosphorus in nutritional supplements. It is one of the more widely used materials, particularly in the nutritional/health food sectors. It is also used in pharmaceutical products because of its compaction properties, and the good flow properties of the coarsegrade material. The predominant deformation mechanism of dibasic calcium phosphate coarse-grade is brittle fracture and this reduces the strain-rate sensitivity of the material, thus allowing easier transition from the laboratory to production scale. However, dibasic calcium phosphate dihydrate is abrasive and a lubricant is required for tableting, for example about 1% w/w of magnesium stearate or about 1% w/w of sodium stearyl fumarate is commonly used.
Two main particle-size grades of dibasic calcium phosphate dihydrate are used in the pharmaceutical industry. The milled material is typically used in wet-granulated, roller-compacted or slugged formulations. The ‘unmilled’ or coarse-grade material is typically used in direct-compression formulations.
Dibasic calcium phosphate dihydrate is nonhygroscopic and stable at room temperature. However, under certain conditions of temperature and humidity, it can lose water of crystallization below 1008℃. This has implications for certain types of packaging and aqueous film coating since the loss of water of crystallization appears to be initiated by high humidity and by implication high moisture vapor concentrations in the vicinity of the dibasic calcium phosphate dihydrate particles.
Dibasic calcium phosphate dihydrate is also used in toothpaste and dentifrice formulations for its abrasive properties.

安全性

Dibasic calcium phosphate dihydrate is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may cause abdominal discomfort.

貯蔵

Dibasic calcium phosphate dihydrate is a nonhygroscopic, relatively stable material. However, under certain conditions the dihydrate can lose water of crystallization. This has implications for both storage of the bulk material and coating and packaging of tablets containing dibasic calcium phosphate dihydrate.
The bulk material should be stored in a well-closed container in a cool, dry place.

純化方法

Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].

不和合性

Dibasic calcium phosphate dihydrate should not be used to formulate tetracycline antibiotics. Dibasic calcium phosphate dihydrate has been reported to be incompatible with indomethacin, aspirin, aspartame, ampicillin, cephalexin, and erythromycin. The surface of dibasic calcium phosphate dihydrate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH.

規制状況(Regulatory Status)

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

りん酸水素カルシウム·2水和物 上流と下流の製品情報

原材料

準備製品


りん酸水素カルシウム·2水和物 生産企業

Global( 244)Suppliers
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hdzhl biotechnology co., ltd
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7789-77-7(りん酸水素カルシウム·2水和物)キーワード:


  • 7789-77-7
  • Calciumhydrogenphosphate,dih
  • Calciumhydrogenphosphate,medicinal
  • Phosphoricacid,calciumsalt(1:1),dihydrate
  • Calcium hydrogen phosphate,agricultural
  • Calcii hydrogenophosphas dihydricus, Calcium hydrogen phosphate dihydrate
  • calcium phosphate,secondary
  • dicalciurn phosphate
  • CALCIUM PHOSPH
  • Calcium hydrogen phosphate dihydrate, extra pure, Ph Eur, USP, BP, FCC, E 341
  • Calcium phosphate di
  • BicalciuM phosphate
  • Bekapress D 2
  • Monohydrogen monocalcium phosphate dihydrate
  • CALCIUM PHOSPHATE, DIBASIC, DIHYDRATE, 98+%
  • DiTab
  • Di-tab
  • calcium bydrogen phosphate for toothpaste
  • calcium phosphate,secondary,for toothpaste
  • calcium hydrogen phosphate for feed
  • calcium phosphate,secondary for feed
  • calcium hydrogen phosphate for food
  • calcium phosphate,secondary for food
  • calcium hydrogen phosphate for medicinal
  • calcium phosphate,seecondary for medicinal
  • CalciuM phosphate, dibasic dihydrate, 98+%, extra pure
  • CalciuM phosphate, dibasic dihydrate, 98+% 1KG
  • Calcium Hydrogen Phosphate Dihydrate Min
  • DIBASIC CALCIUM PHOSPHATE DIHYDRATE [USP ] GRADE: POWDER/MILLED PRODUCT CODE: DD/ 02/RU
  • Dicalcium phosphate dihydrate DC
  • Dicalcium phosphate dihydrate dental grade
  • りん酸水素カルシウム二水和物
  • りん酸水素カルシウム·2水和物
  • りん酸カルシウム二水和物,第二
  • リン酸2CA二水和物
  • リン酸水素カルシウム二水和
  • りん酸一水素カルシウム,2水和物
  • りん酸二カルシウム二水和物
  • リン酸一水素カルシウム
  • リン酸水素カルシウム水和物「製造専用」
  • リン酸カルシウム, 二塩基酸 二水和物
  • リン酸水素カルシウム 二水和物
  • リン酸水素カルシウム水和物
  • リン酸水素カルシウム水和物 (JP17)
  • リン酸2CA
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