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二酸化ケイ素(アモルファス)

二酸化ケイ素(アモルファス) 化学構造式
112945-52-5
CAS番号.
112945-52-5
化学名:
二酸化ケイ素(アモルファス)
别名:
二酸化ケイ素, 無定形;二酸化ケイ素(アモルファス);砂;シリカ, FUMED;Silicon(IV) oxide, 99+%, 0.012 micron (fumed コロイド状 シリカ)
英語化学名:
Silica, fumed
英語别名:
SAND;ludox;sg-67;nyacol;acticel;aquafil;nalcoag;cataloid;dicalite;santocel
CBNumber:
CB9199390
化学式:
O2Si
分子量:
60.08
MOL File:
112945-52-5.mol

二酸化ケイ素(アモルファス) 物理性質

融点 :
>1600°C
比重(密度) :
2.3 lb/cu.ft at 25 °C (bulk density)(lit.)
屈折率 :
n20/D 1.46(lit.)
溶解性:
Practically insoluble in organic solvents, water, and acids, except hydrofluoric acid; soluble in hot solutions of alkali hydroxide. Forms a colloidal dispersion with water. For Aerosil, solubility in water is 150 mg/L at 258℃ (pH 7).
外見 :
powder
比重:
2.2
Hydrolytic Sensitivity:
5: forms reversible hydrate
CAS データベース:
112945-52-5(CAS DataBase Reference)
EPAの化学物質情報:
Silica, amorphous, fumed, cryst.-free (112945-52-5)

安全性情報

Sフレーズ  24/25
WGK Germany  2
RTECS 番号 VV7310000
TSCA  Yes
HSコード  28112290

二酸化ケイ素(アモルファス) 価格 もっと(10)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01SRM93-1434
Silicon(IV) oxide, 99+%, 0.012 micron (fumed colloidal silica)
112945-52-5 100g ¥8200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01SRM93-1434
Silicon(IV) oxide, 99+%, 0.012 micron (fumed colloidal silica)
112945-52-5 500g ¥23800 2021-03-23 購入
Sigma-Aldrich Japan 381276 シリカ, fumed 99.8%
Silica 99.8%
112945-52-5 100g ¥5650 2021-03-23 購入
Sigma-Aldrich Japan 381276 シリカ, fumed 99.8%
Silica 99.8%
112945-52-5 500g ¥11600 2021-03-23 購入
林純薬工業株式会社 10087H50 ---
Silica gel orange ---
112945-52-5 500g ¥4000 2021-03-22 購入

二酸化ケイ素(アモルファス) 化学特性,用途語,生産方法

定義

本品は、次の化学式で表される無機酸化物である。

化粧品の成分用途

不透明化剤、非活性剤系分散剤、抗ケーキング剤、吸着剤、研磨.スクラブ剤、増量剤

化学的特性

Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder

化学的特性

Colloidal silicon dioxide is a submicroscopic fumed silica with a particle size of about 15 nm. It is a light, loose, bluish-white-colored, odorless, tasteless, amorphous powder.

調製方法

Colloidal silicon dioxide is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 18008℃ using a hydrogen–oxygen flame. Rapid cooling from the molten state during manufacture causes the product to remain amorphous.

応用例(製薬)

Colloidal silicon dioxide is widely used in pharmaceuticals, cosmetics, and food products. Its small particle size and large specific surface area give it desirable flow characteristics that are exploited to improve the flow properties of dry powders in a number of processes such as tableting and capsule filling.
Colloidal silicon dioxide is also used to stabilize emulsions and as a thixotropic thickening and suspending agent in gels and semisolid preparations. With other ingredients of similar refractive index, transparent gels may be formed. The degree of viscosity increase depends on the polarity of the liquid (polar liquids generally require a greater concentration of colloidal silicon dioxide than nonpolar liquids). Viscosity is largely independent of temperature. However, changes to the pH of a system may affect the viscosity1.
In aerosols, other than those for inhalation, colloidal silicon dioxide is used to promote particulate suspension, eliminate hard settling, and minimize the clogging of spray nozzles. Colloidal silicon dioxide is also used as a tablet disintegrant and as an adsorbent dispersing agent for liquids in powders. Colloidal silicon dioxide is frequently added to suppository formulations containing lipophilic excipients to increase viscosity, prevent sedimentation during molding, and decrease the release rate. Colloidal silicon dioxide is also used as an adsorbent during the preparation of wax microspheres; as a thickening agent for topical preparations; and has been used to aid the freeze-drying of nanocapsules and nanosphere suspensions.

安全性プロファイル

Poison by intraperitoneal, intravenous, and intratracheal routes. Moderately toxic by ingestion. An inhalation hazard. Much less toxic than crystalhe forms. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Does not cause silicosis. See also other silica entries

安全性

Colloidal silicon dioxide is widely used in oral and topical pharmaceutical products and is generally regarded as an essentially nontoxic and nonirritant excipient. However, intraperitoneal and subcutaneous injection may produce local tissue reactions and/or granulomas. Colloidal silicon dioxide should therefore not be administered parenterally.
LD50 (rat, IV): 0.015 g/kg
LD50 (rat, oral): 3.16 g/kg

職業ばく露

Amorphous fumed silica is used as a mineral, natural or synthetic fiber. A potential danger to those involved in the production and handling of fumed silica for paint pigments or catalysts. Diatomaceous earth is used in clarifying liquids, in manufacture of fire brick and heat insulators; used as a filtering agent; as a filler in construction materials; pesticides, paints, and varnishes. A potential danger to those involved in mining of diatomaceous earth or fabrication of products there from.

貯蔵

Colloidal silicon dioxide is hygroscopic but adsorbs large quantities of water without liquefying. When used in aqueous systems at a pH 0–7.5, colloidal silicon dioxide is effective in increasing the viscosity of a system. However, at a pH greater than 7.5 the viscosityincreasing properties of colloidal silicon dioxide are reduced; and at a pH greater than 10.7 this ability is lost entirely since the silicon dioxide dissolves to form silicates. Colloidal silicon dioxide powder should be stored in a well-closed container.

純化方法

Purification of silica for high technology applications uses isopiestic vapour distillation from concentrated volatile acids and is absorbed in high purity water. The impurities remain behind. Preliminary cleaning to remove surface contaminants uses dip etching in HF or a mixture of HCl, H2O2 and deionised water [Phelan & Powell Analyst 109 1299 1984].

不和合性

Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature.

不和合性

Incompatible with diethylstilbestrol preparations.

廃棄物の処理

Sanitary landfill.

規制状況(Regulatory Status)

GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions, and tablets; transdermal, rectal, and vaginal preparations). Also approved by the FDA as a food additive and for food contact. Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

二酸化ケイ素(アモルファス) 上流と下流の製品情報

原材料

準備製品


二酸化ケイ素(アモルファス) 生産企業

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112945-52-5(二酸化ケイ素(アモルファス))キーワード:


  • 112945-52-5
  • acticel
  • SILICA GEL 7G
  • SILICA GEL 8-20 MESH
  • SILICA GEL 12-28 MESH
  • SILICA GEL 100
  • SILICA GEL 60
  • SILICA GEL 30
  • SILICA GEL 60 G
  • WATER-IMPREGNATED SILICA GEL
  • WAKOSIL(R) C-200
  • WAKOSIL(R) C-300
  • WAKOSIL(R) 5SIL
  • WAKOSIL(R) 5SIL-120
  • WAKOSIL(R) 7SIL-120
  • WAKOSIL(R) 25SIL
  • WAKOSIL(R) 40SIL
  • WAKOGEL(R) B-0
  • WAKOGEL(R) B-0 F
  • WAKOGEL(R) B-10
  • WAKOGEL(R) B-5
  • WAKOGEL(R) B-5F
  • WAKOGEL(R) B-5 FM
  • WAKOGEL(R) C-100
  • WAKOGEL(R) C-200
  • WAKOGEL(R) C-200E
  • WAKOGEL(R) C-300
  • WAKOGEL(R) C-300E
  • WAKOGEL(R) C-300HG
  • WAKOGEL(R) C-400HG
  • WAKOGEL(R) C-500HG
  • 二酸化ケイ素, 無定形
  • 二酸化ケイ素(アモルファス)
  • シリカ, FUMED
  • Silicon(IV) oxide, 99+%, 0.012 micron (fumed コロイド状 シリカ)
  • シリカ
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