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전분글리콜산나트륨 구조식 이미지
카스 번호:
Sodium carboxyl methylstarch
CMS-Na;Primojel;explotab;PRIMOJEL(R);Sodium Starch g;Sodium Starch GL;Carboxy methyl starc;SODIUM STARCH GLYCOLATE;SODIUM STARCH GLYCOLLATE;Sodiumcarboxymethylstarch
포뮬러 무게:
MOL 파일:
Mol file

전분글리콜산나트륨 속성

저장 조건
Inert atmosphere,Room Temperature
Practically insoluble in methylene chloride. It gives a translucent suspension in water.
물리적 상태
CAS 데이터베이스
Starch, carboxymethyl ether, sodium salt (9063-38-1)


WGK 독일 1
HS 번호 3505100092
기존화학 물질 KE-32138

전분글리콜산나트륨 C화학적 특성, 용도, 생산

화학적 성질

White or almost white, fine, free-flowing powder, very hygroscopic.

화학적 성질

Sodium starch glycolate is a white or almost white free-flowing very hygroscopic powder. The PhEur 6.0 states that when examined under a microscope it is seen to consist of: granules, irregularly shaped, ovoid or pear-shaped, 30–100 mm in size, or rounded, 10–35 mm in size; compound granules consisting of 2–4 components occur occasionally; the granules have an eccentric hilum and clearly visible concentric striations. Between crossed nicol prisms, the granules show a distinct black cross intersecting at the hilum; small crystals are visible at the surface of the granules. The granules show considerable swelling in contact with water.


Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either directcompression or wet-granulation processes.

생산 방법

Sodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also crosslinked using either sodium trimetaphosphate (Types A and B) or dehydration (Type C).
Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline, nonaqueous medium, typically denatured ethanol or methanol, followed by neutralization with citric acid, acetic acid, or some other acid. Vivastar P is manufactured in methanolic medium, and Explotab in ethanolic medium.

Pharmaceutical Applications

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. The usual concentration employed in a formulation is between 2% and 8%, with the optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.
Although the effectiveness of many disintegrants is affected by the presence of hydrophobic excipients such as lubricants, the disintegrant efficiency of sodium starch glycolate is unimpaired. Increasing the tablet compression pressure also appears to have no effect on disintegration time.
Sodium starch glycolate has also been investigated for use as a suspending vehicle.


Sodium starch glycolate is widely used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may be harmful.


Tablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.
The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity.

비 호환성

Sodium starch glycolate is incompatible with ascorbic acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

전분글리콜산나트륨 준비 용품 및 원자재


준비 용품

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BOC Sciences
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