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벤조 산, 나트륨 염

벤조 산, 나트륨 염
벤조 산, 나트륨 염 구조식 이미지
카스 번호:
532-32-1
한글명:
벤조 산, 나트륨 염
동의어(한글):
소다의벤조산;벤조산,나트륨염;벤조산나트륨;벤조산나트륨;소듐벤조에이트
상품명:
Sodium benzoate
동의어(영문):
ucephan;PUROX S;antimol;sobenate;FEMA 3025;BENZOTRON;BENZOTRON(R);benzoansodny;femanumber3025;NATRII BENZOAS
CBNumber:
CB0698779
분자식:
C7H5NaO2
포뮬러 무게:
144.10317
MOL 파일:
532-32-1.mol

벤조 산, 나트륨 염 속성

녹는점
>300 °C(lit.)
밀도
1,44 g/cm3
FEMA
3025 | SODIUM BENZOATE
인화점
>100°C
저장 조건
Store at RT.
용해도
H2O: 1 M at 20 °C, clear, colorless
물리적 상태
Crystals, Granules, Flakes or Crystalline Powder
색상
White
수소이온지수(pH)
7.0-8.5 (25℃, 1M in H2O)
수용성
soluble
Merck
14,8582
BRN
3572467
안정성
Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids.
InChIKey
WXMKPNITSTVMEF-UHFFFAOYSA-M
CAS 데이터베이스
532-32-1(CAS DataBase Reference)
NIST
Sodium benzoate(532-32-1)
EPA
Benzoic acid, sodium salt(532-32-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38-62-63-68-36
안전지침서 24/25-36-26
WGK 독일 1
RTECS 번호 DH6650000
TSCA Yes
HS 번호 29163100
유해 물질 데이터 532-32-1(Hazardous Substances Data)
독성 LD50 orally in rats: 4.07 g/kg (Smyth, Carpenter)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P321 (…) 처치를 하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

벤조 산, 나트륨 염 MSDS


Sodium benzoate

벤조 산, 나트륨 염 C화학적 특성, 용도, 생산

물성

안정적이지만 습기에 민감합니다. 강한 산화제, 알칼리성, 무기산과는 혼합 할 수 없습니다.

용도

나트륨 벤조 에이트는 항균 및 향미 특성 때문에 다양한 제품에 사용되어 왔습니다. 세계에서 가장 광범위하게 적용되는 식품 방부제로 식품 및 청량 음료 제품에 포함됩니다. 벤조산 나트륨은 마가린, 살사, 메이플 시럽, 절임, 보존 식품, 잼 및 젤리에 사용됩니다. 식품 안의 용도 외에도 안식향산 나트륨은 염료 제조 과정에서 중간체로 사용됩니다. 그것은 항균제와 녹 및 곰팡이 방지제입니다. 벤조산 나트륨은 또한 담배 및 의약품 제제에 사용됩니다. 유리 산 형태에서, 그것은 살균제로 사용됩니다.

용도

나트륨 벤조 에이트 (sodium benzoate)는 아미노산에 결합하는 능력으로 인해 우레아 순환 장애 치료제로 널리 사용됩니다. 이것은 이러한 아미노산의 배설과 암모니아 수준의 감소로 이어진다. 최근의 연구에 따르면 나트륨 벤조 에이트는 정신 분열증의 추가 치료로서 유용 할 수 있습니다. 나트륨 벤조 에이트는 고 암모니아 혈증 치료에도 사용됩니다.

용도

나트륨 벤조 에이트는 불꽃에 휘파람을 불어 넣은 분말로 불꽃 놀이에 사용됩니다.

용도

나트륨 벤조 에이트 (sodium benzoate)는 마가린, 청량 음료, 피클, 젤리 및 잼을 비롯한 여러 유형의 식품에 방부제로 사용되는 화학 물질입니다.

개요

Sodium benzoate has the chemical formula NaC7H5O2; it is a widely used food preservative, with E number E211. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid.

화학적 성질

Benzoic acid is almost odorless or exhibits a sweet, faint, balsamic odor and a sweet–sour to acrid taste. For a detailed description, refer to Burdock (1997).

화학적 성질

Sodium benzoate occurs as a white granular or crystalline, slightly hygroscopic powder. It is odorless, or with faint odor of benzoin and has an unpleasant sweet and saline taste.

화학적 성질

Sodium benzoate is a white crystalline solid. It is odorless and nonflammable

화학적 성질

white crystalline powder

출처

Benzoic acid occurs naturally in many plants and in animals. The salt is not found to occur naturally.

용도

Sodium benzoate is a preservative. It is bacteriostatic and fungistatic under acidic conditions. It is most widely used in acidic foods such as salad dressings (vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (vinegar), and condiments. It is also used as a preservative in medicines and cosmetics. As a food additive, sodium benzoate has the E number E211.
It is also used in fireworks as a fuel in whistle mix, a powder that emits a whistling noise when compressed into a tube and ignited. The fuel is also one of the fastest burning rocket fuels and provides a lot of thrust and smoke. It does have its downsides: there is a high danger of explosion when the fuel is sharply compressed because of the fuel's sensitivity to impact.

용도

Sodium Benzoate is a preservative that is the sodium salt of benzoic acid. it converts to benzoic acid, which is the active form. it has a solubility in water of 50 g in 100 ml at 25°c. sodium benzoate is 180 times as soluble in water at 25°c as is the parent acid. the optimum functionality occurs between ph 2.5 and 4.0 and it is not recom- mended above ph 4.5. it is active against yeasts and bacteria. it is used in acidic foods such as fruit juices, jams, relishes, and bever- ages. its use level ranges from 0.03 to 0.10%.

용도

Vasodilator

용도

A benzene compound used as a synthetic reagent.

용도

sodium benzoate is a non-toxic, organic salt preservative that is particularly effective against yeast, with some activity against molds and bacteria. It is generally used in concentrations of 0.1 to 0.2 percent.

용도

Antimicrobial agent, flavoring agent and adjuvant in food; not to exceed a maximum level of 0.1% in food (21 CFR, 184.1733, 582.3733). Antifungal and bacteriostatic preservative in pharmaceuticals at concentrations of ~0.1%. Clinical reagent (bilirubin assay).

정의

ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.

생산 방법

Prepared by the treatment of benzoic acid with either sodium carbonate or sodium bicarbonate.

생산 방법

Sodium benzoate is prepared by adding benzoic acid to a hot concentrated solution of sodium carbonate until effervescence ceases. The solution is then evaporated, cooled and allowed to crystallize or evaporate to dryness, and then granulated.

정의

sodium benzoate: An either colourlesscrystalline or white amorphouspowder, C6H5COONa, soluble inwater and slightly soluble in ethanol.It is made by the reaction of sodiumhydroxide with benzoic acid and isused in the dyestuffs industry and asa food preservative. It was formerlyused as an antiseptic.

제조 방법

Produced by the neutralization of benzoic acid with sodium bicarbonate, sodium carbonate or sodium hydroxide.

위험도

Use in foods limited to 0.1%.

Pharmaceutical Applications

Sodium benzoate is used primarily as an antimicrobial preservative in cosmetics, foods, and pharmaceuticals. It is used in concentrations of 0.02–0.5% in oral medicines, 0.5% in parenteral products, and 0.1–0.5% in cosmetics. The usefulness of sodium benzoate as a preservative is limited by its effectiveness over a narrow pH range.
Sodium benzoate is used in preference to benzoic acid in some circumstances, owing to its greater solubility. However, in some applications it may impart an unpleasant flavor to a product. Sodium benzoate has also been used as a tablet lubricant at 2–5% w/w concentrations. Solutions of sodium benzoate have also been administered, orally or intravenously, in order to determine liver function.

Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Larger doses of 8-10 g by mouth may cause nausea and vomiting. Small doses have little or no effect. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Na2O. See also BENZOIC ACID.

Safety

Ingested sodium benzoate is conjugated with glycine in the liver to yield hippuric acid, which is excreted in the urine. Symptoms of systemic benzoate toxicity resemble those of salicylates. Whereas oral administration of the free-acid form may cause severe gastric irritation, benzoate salts are well tolerated in large quantities: e.g. 6 g of sodium benzoate in 200mL of water is administered orally as a liver function test.
Clinical data have indicated that sodium benzoate can produce nonimmunological contact urtcaria and nonimmunological immediate contact reactions. However, it is also recognized that these reactions are strictly cutaneous, and sodium benzoate can therefore be used safely at concentrations up to 5%. However, this nonimmunological phenomenon should be considered when designing formulations for infants and children.
Other adverse effects include anaphylaxis and urticarial reactions, although a controlled study has shown that the incidence of urticaria in patients given benzoic acid is no greater than that with a lactose placebo.
It has been recommended that caffeine and sodium benzoate injection should not be used in neonates; however, sodium benzoate has been used by others in the treatment of some neonatal metabolic disorders. It has been suggested that there is a general adverse effect of benzoate preservatives on the behavior of 3-yearold children, which is detectable by parents, but not by a simple clinical assessment.
The WHO acceptable daily intake of total benzoates, calculated as benzoic acid, has been estimated at up to 5 mg/kg of bodyweight.
LD50 (mouse, IM): 2.3 g/kg
LD50 (mouse, IV): 1.4 g/kg
LD50 (mouse, oral): 1.6 g/kg
LD50 (rabbit, oral): 2.0 g/kg
LD50 (rat, IV): 1.7 mg/kg
LD50 (rat, oral): 4.1 g/kg

Safety

In combination with ascorbic acid (vitamin C, E300), sodium benzoate and potassium benzoate form benzene, a known carcinogen. However, in most beverages that contain both, the benzene levels are below those considered dangerous for consumption. Heat, light and shelf life can affect the rate at which benzene is formed.

잠재적 노출

Sodium benzoate is used as a food and feed additive, flavor, packaging material; pharmaceutical; preservative for food products and tobacco; anti-fungal agent; antiseptic, rust, and mildew inhibitor; intermediate in the manufacture of dyes. Used as a human hygiene biocidal product.

저장

Aqueous solutions may be sterilized by autoclaving or filtration. The bulk material should be stored in a well-closed container, in a cool, dry place.

운송 방법

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise it from EtOH (12mL/g). [Beilstein 9 IV 27.]

Mechanism of food preservation

The mechanism starts with the absorption of benzoic acid into the cell. If the intracellular pH changes to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase is decreased by 95 %, thereby inhibiting the growth and survival of micro-organisms that cause food spoilage.

비 호환성

Incompatible with quaternary compounds, gelatin, ferric salts, calcium salts, and salts of heavy metals, including silver, lead, and mercury. Preservative activity may be reduced by interactions with kaolin or nonionic surfactants.

비 호환성

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; oral capsules, solutions and tablets; rectal; and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

벤조 산, 나트륨 염 준비 용품 및 원자재

원자재

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