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중탄산나트륨(중조)

중탄산나트륨(중조)
중탄산나트륨(중조) 구조식 이미지
카스 번호:
144-55-8
한글명:
중탄산나트륨(중조)
동의어(한글):
모노나트륨탄산;소다의이탄산;탄산나트륨;탄산나트륨염(1:1);탄산모노나트륨염;탄산수소나트륨;모노나트륨탄산수소;베이킹소다;이탄산나트륨;중탄산나트륨(중조);탄산소다;이탄산나트륨(SODIUMBICARBONATE);소듐바이카보네이트
상품명:
Sodium bicarbonate
동의어(영문):
neut;NAHCO3;meylon;soludal;jusonin;sodamint;col-evac;soda(van);seldevichy;BAKING SODA
CBNumber:
CB7492884
분자식:
CHNaO3
포뮬러 무게:
84.01
MOL 파일:
144-55-8.mol

중탄산나트륨(중조) 속성

녹는점
>300 °C(lit.)
끓는 점
851°C
밀도
2.16 g/mL at 25 °C(lit.)
굴절률
1.500
저장 조건
2-8°C
용해도
H2O: 1 M at 20 °C, clear, colorless
물리적 상태
solution (7.5%)
색상
White
Specific Gravity
2.159
pH 범위
7.8 - 8.2
수소이온지수(pH)
8.3 (0.1molfreshly prepared)
산도 계수 (pKa)
(1) 6.37, (2) 10.25 (carbonic (at 25℃)
수용성
9 g/100 mL (20 ºC)
Merck
14,8583
BRN
4153970
안정성
Stable.
CAS 데이터베이스
144-55-8(CAS DataBase Reference)
EPA
Carbonic acid monosodium salt(144-55-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
안전지침서 24/25
WGK 독일 1
RTECS 번호 VZ0950000
TSCA Yes
HS 번호 28363000
유해 물질 데이터 144-55-8(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 4220 mg/kg
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

중탄산나트륨(중조) MSDS


Sodium bicarbonate

중탄산나트륨(중조) C화학적 특성, 용도, 생산

개요

탄산수소나트륨(중조)은 천연으로 산출되는 경우도 있으나 이는 순도가 낮을 뿐 만 아니라 불순물을 다량 함유하므로, 일반적으로 소다회 용액에 이산화탄소를 흡수시키는 공업적 방 법이 널리 이용됩니다.
주 용도는 복합 및 단미사료로서 약알칼리성 완충제로 사용되며, 식품첨 가 물로서 제빵·제과에 이용하는 베이킹파우더의 주원료로 사용됩니다. 또한 제혁공정중에 크롬 탄닝 (TANNING)후의 산 중화제로, 그외에 염료, 의약품원료등 다양한 용도로 사용됩니다. 알칼리원으로서 광범위하게 사용되고 있는 기초화학제품으로 섬유, 비누, 제지, 식품, 전 기 등 거의 모든 분야에 사용되고 있으며, 최근에는 환경오염 문제가 심각하게 대두됨에 따라 수질 및 대기오염 방지 시설에도 많이 사용되고 있습니다.

용도

1) 식품첨가물 : 베이킹파우더의 주성분
2) 사 료 용 : 완충제
3) 피 혁 : 중 화제 (pH)조절용
4) 의 약 : 소화제등
5) 기 타 : 세척제, 지질안정제, 수처리제, 세제등

개요

Sodium bicarbonate, which is the compound commonly called baking soda, exists as a white, odorless, crystalline solid. It occurs naturally as the mineral nahcolite, which derives its name from its chemical formula by replacing the “3” in NaHCO3 with the ending “lite.” The world’s main source of nahcolite is the Piceance Creek Basin in western Colorado, which is part of the larger Green River formation. Sodium bicarbonate is extracted using solution mining by pumping hot water through injection wells to dissolve the nahcolite from the Eocene beds where it occurs 1,500 to 2,000 feet below the surface. The dissolved sodium bicarbonate is pumped to the surface where it is treated to recover NaHCO3 from solution. Sodium bicarbonate can also be produced from the trona deposits, which is a source of sodium carbonates (see Sodium Carbonate).

화학적 성질

Sodium bicarbonate, NaHC03, also known as sodium acid carbonate and baking soda, is a white water-soluble crystalline solid.It has an alkaline taste, loses carbon dioxide at 270°C (518 °F).and is used in food preparation. Sodium bicarbonate also finds use as a medicine,a butter preservative, in ceramics,and to prevent timber mold.

화학적 성질

Sodium bicarbonate occurs as an odorless, white, crystalline powder with a saline, slightly alkaline taste. The crystal structure is monoclinic prisms. Grades with different particle sizes, from a fine powder to free-flowing uniform granules, are commercially available.

용도

sodium bicarbonate (baking soda) is an inorganic salt used as a buffering agent and a pH adjuster, it also serves as a neutralizer. It is used in skin-smoothing powders.

용도

Sodium Bicarbonate is a leavening agent with a ph of approxi- mately 8.5 in a 1% solution at 25°c. it functions with food grade phosphates (acidic leavening compounds) to release carbon dioxide which expands during the baking process to provide the baked good with increased volume and tender eating qualities. it is also used in dry-mix beverages to obtain carbonation, which results when water is added to the mix containing the sodium bicarbonate and an acid. it is a component of baking powder. it is also termed baking soda, bicarbonate of soda, sodium acid carbonate, and sodium hydrogen carbonate.

용도

manufacture of many sodium salts; source of CO2; ingredient of baking powder, effervescent salts and beverages; in fire extinguishers, cleaning Compounds.

용도

Sodium bicarbonate, used in the formof baking soda and baking powder, is the most common leavening agent. When baking soda,which is an alkaline substance, is added to a mix, it reacts with an acid ingredient to producecarbon dioxide. The reaction can be represented as: NaHCO3(s) + H+ → Na+(aq) + H2O(l) +CO2(g), where H+ is supplied by the acid. Baking powders contain baking soda as a primaryingredient along with acid and other ingredients. Depending on the formulation, bakingpowders can produce carbon dioxide quickly as a single action powder or in stages, as with adouble-action powder. Baking soda is also used as a source of carbon dioxide for carbonatedbeverages and as a buffer.In addition to baking, baking soda has numerous household uses. It is used as a generalcleanser, a deodorizer, an antacid, a fire suppressant, and in personal products such as toothpaste.Sodium bicarbonate is a weak base in aqueous solution, with a pH of about 8. Thebicarbonate ion (HCO3-) has amphoteric properties, which means it can act as either an acidor a base. This gives baking soda a buff ering capacity and the ability to neutralize both acidsand bases. Food odors resulting from acidic or basic compounds can be neutralized with bakingsoda into odor-free salts. Because sodium bicarbonate is a weak base, it has a greater abilityto neutralize acid odors.
The second largest use of sodium bicarbonate, accounting for approximately 25% of totalproduction, is as an agricultural feed supplement. In cattle it helps maintain rumen pH andaids fiber digestibility; for poultry it helps maintain electrolyte balance by providing sodiumin the diet, helps fowl tolerate heat, and improves eggshell quality.
Sodium bicarbonate is used in the chemical industry as a buff ering agent, a blowingagent, a catalyst, and a chemical feedstock. Sodium bicarbonate is used in the leather tanningindustry for pretreating and cleaning hides and to control pH during the tanning process.Heating sodium bicarbonate produces sodium carbonate, which is used for soap and glassmaking.Sodium bicarbonate is incorporated into pharmaceuticals to serve as an antacid, abuff ering agent, and in formulations as a source of carbon dioxide in eff ervescent tablets. Drychemical type BC fire extinguishers contain sodium bicarbonate (or potassium bicarbonate).Other uses of bicarbonate include pulp and paper processing, water treatment, and oil welldrilling.

생산 방법

Most sodium bicarbonate in the United States is made synthetically by the reaction of sodium carbonate solution (Na2CO3) with carbon dioxide: Na2CO3(aq) + H2O(l) + CO2(g) → 2NaHCO3(aq). It can also be produced using the Solvay process, which uses ammonia, carbon dioxide, and salt to produce sodium bicarbonate according to the following series of reactions: 2NH3(g) + CO2(g) + H2O(l) → (NH4)2CO3(aq)
(NH4)2CO3(aq) + CO2(g) + H2O(l) → 2NH3HCO3(aq)
NH4HCO3(aq) + NaCl(aq) → NaHCO3(s) + NH4Cl(aq).

정의

Baking soda: A white solid formed either by passing an excess of carbon dioxide through sodium carbonate or hydroxide solution, or by precipitation when cold concentrated solutions of sodium chloride and ammonium hydrogencarbonate are mixed. Sodium hydrogencarbonate decomposes on heating to give sodium carbonate, carbon dioxide, and water. With dilute acids, it yields carbon dioxide. It is used as a constituent of baking powder, in effervescent beverages, and in fire extinguishers. Its aqueous solutions are alkaline as a result of salt hydrolysis. Sodium hydrogencarbonate forms monoclinic crystals.

생산 방법

Sodium bicarbonate is manufactured either by passing carbon dioxide into a cold saturated solution of sodium carbonate, or by the ammonia–soda (Solvay) process, in which first ammonia and then carbon dioxide is passed into a sodium chloride solution to precipitate sodium bicarbonate while the more soluble ammonium chloride remains in solution.

상표명

Neut (Abbott); Soda Mint (Lilly).

일반 설명

Odorless white crystalline powder or lumps. Slightly alkaline (bitter) taste. pH (of freshly prepared 0.1 molar aqueous solution): 8.3 at 77°F. pH (of saturated solution): 8-9. Non-toxic.

공기와 물의 반응

Stable in dry air, but slowly decomposes in moist air. Moderately water soluble. Decomposes slowly in water (accelerated by agitation) .

반응 프로필

Sodium bicarbonate reacts exothermically with acids to generate non-toxic carbon dioxide gas. Decomposes when heated. Incompatible with acids, acidic salts (dopamine hydrochloride, pentazocine lactate, many alkaloidal salts) aspirin and bismuth salicylate.

화재위험

Literature sources indicate that Sodium bicarbonate is noncombustible.

Pharmaceutical Applications

Sodium bicarbonate is generally used in pharmaceutical formulations as a source of carbon dioxide in effervescent tablets and granules. It is also widely used to produce or maintain an alkaline pH in a preparation.
In effervescent tablets and granules, sodium bicarbonate is usually formulated with citric and/or tartaric acid; combinations of citric and tartaric acid are often preferred in formulations as citric acid alone produces a sticky mixture that is difficult to granulate, while if tartaric acid is used alone, granules lose firmness. When the tablets or granules come into contact with water, a chemical reaction occurs, carbon dioxide is evolved, and the product disintegrates. Melt granulation in a fluidized bed dryer has been suggested as a one-step method for the manufacture of effervescent granules composed of anhydrous citric acid and sodium bicarbonate, for subsequent compression into tablets.
Tablets may also be prepared with sodium bicarbonate alone since the acid of gastric fluid is sufficient to cause effervescence and disintegration. Sodium bicarbonate is also used in tablet formulations to buffer drug molecules that are weak acids, thereby increasing the rate of tablet dissolution and reducing gastric irritation.
The effects of tablet binders, such as polyethylene glycols, microcrystalline cellulose, silicified microcrystalline cellulose, pregelatinized starch, and povidone, on the physical and mechanical properties of sodium bicarbonate tablets have also been investigated.( 8,9) Additionally, sodium bicarbonate is used in solutions as a buffering agent for erythromycin, lidocaine, local anesthetic solutions, and total parenteral nutrition (TPN) solutions. In some parenteral formulations, e.g. niacin, sodium bicarbonate is used to produce a sodium salt of the active ingredient that has enhanced solubility. Sodium bicarbonate has also been used as a freeze-drying stabilizer and in toothpastes.
Recently, sodium bicarbonate has been used as a gas-forming agent in alginate raft systems and in floating, controlledrelease oral dosage forms for a range of drugs. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. Sodium bicarbonate has also been included in formulations of vaginal bioadhesive tablets and in carbon dioxide releasing suppositories.
Therapeutically, sodium bicarbonate may be used as an antacid, and as a source of the bicarbonate anion in the treatment of metabolic acidosis. Sodium bicarbonate may also be used as a component of oral rehydration salts and as a source of bicarbonate in dialysis fluids; it has also been suggested as a means of preventing radiocontrast-induced nephrotoxicity.
Sodium bicarbonate is used in food products as an alkali or as a leavening agent, e.g. baking soda.

Pharmaceutical Applications

Sodium bicarbonate is usually administered orally in order to regulate the serum pH. Imbalances of the plasma pH can be due to problems occurring in the kidneys such as renal tubular acidosis. Within the kidneys, blood is filtered before it passes through the tubular part of the nephrons where re-absorption or secretion of important salts and others takes place. In renal tubular acidosis, the kidneys either fail to filter or secrete acid ions (H+) from the plasma (secretion takes place in the distal tubule), or to recover bicarbonate ions (HCO3-) from the filtrate (passive re-absorption takes place in the proximal tubule, active re-absorption at the distal tubule), which is necessary to balance the pH. In the view of this mode of action, the pharmaceutically active component of sodium bicarbonate is the bicarbonate anion, but the cation Na+ is responsible for solubility and compatibility.

생물학적 활성

Commonly used laboratory reagent

Safety Profile

Low toxicity by ingestion. An experimental teratogen. A nuisance dust. Human systemic effects: changes in potassium levels, increased urine volume, metabolic acidosis, nausea or vomiting, respiratory changes, sodium level changes. Mutation data reported.

Safety

Sodium bicarbonate is used in a number of pharmaceutical formulations including injections and ophthalmic, otic, topical, and oral preparations.
Sodium bicarbonate is metabolized to the sodium cation, which is eliminated from the body by renal excretion, and the bicarbonate anion, which becomes part of the body’s bicarbonate store. Any carbon dioxide formed is eliminated via the lungs. Administration of excessive amounts of sodium bicarbonate may thus disturb the body’s electrolyte balance, leading to metabolic alkalosis or possibly sodium overload with potentially serious consequences. The amount of sodium present in antacids and effervescent formulations has been sufficient to exacerbate chronic heart failure, especially in elderly patients.
Orally ingested sodium bicarbonate neutralizes gastric acid with the evolution of carbon dioxide and may cause stomach cramps and flatulence.
When used as an excipient, sodium bicarbonate is generally regarded as an essentially nontoxic and nonirritant material.
LD50 (mouse, oral): 3.36 g/kg
LD50 (rat, oral): 4.22 g/kg

Veterinary Drugs and Treatments

Sodium bicarbonate is indicated to treat metabolic acidosis and alkalinize the urine. It is also used as adjunctive therapy in treating hypercalcemic or hyperkalemia crises.

저장

When heated to about 50℃, sodium bicarbonate begins to dissociate into carbon dioxide, sodium carbonate, and water; on heating to 250–300℃, for a short time, sodium bicarbonate is completely converted into anhydrous sodium carbonate. However, the process is both time- and temperature-dependent, with conversion 90% complete within 75 minutes at 93°C. The reaction proceeds via surface-controlled kinetics; when sodium bicarbonate crystals are heated for a short period of time, very fine needleshaped crystals of anhydrous sodium carbonate are formed on the sodium bicarbonate surface.
The effects of relative humidity and temperature on the moisture sorption and stability of sodium bicarbonate powder have been investigated. Sodium bicarbonate powder is stable below 76% relative humidity at 25℃ and below 48% relative humidity at 40℃. At 54% relative humidity, the degree of pyrolytic decarboxylation of sodium bicarbonate should not exceed 4.5% in order to avoid detrimental effects on stability.
At ambient temperatures, aqueous solutions slowly decompose with partial conversion into the carbonate; the decomposition is accelerated by agitation or heat. Aqueous solutions begin to break up into carbon dioxide and sodium carbonate at about 20°C, and completely on boiling.
Aqueous solutions of sodium bicarbonate may be sterilized by filtration or autoclaving. To minimize decomposition of sodium bicarbonate by decarboxylation on autoclaving, carbon dioxide is passed through the solution in its final container, which is then hermetically sealed and autoclaved. The sealed container should not be opened for at least 2 hours after it has returned to ambient temperature, to allow time for the complete reformation of the bicarbonate from the carbonate produced during the heating process. Aqueous solutions of sodium bicarbonate stored in glass containers may develop deposits of small glass particles. Sediments of calcium carbonate with traces of magnesium or other metal carbonates have been found in injections sterilized by autoclaving; these are due to impurities in the bicarbonate or to extraction of calcium and magnesium ions from the glass container. Sedimentation may be retarded by the inclusion of 0.01–0.02% disodium edetate.
Sodium bicarbonate is stable in dry air but slowly decomposes in moist air and should therefore be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise it from hot water (6mL/g). The solid should not be heated above 40o due to the formation of carbonate.

비 호환성

Sodium bicarbonate reacts with acids, acidic salts, and many alkaloidal salts, with the evolution of carbon dioxide. Sodium bicarbonate can also intensify the darkening of salicylates. In powder mixtures, atmospheric moisture or water of crystallization from another ingredient is sufficient for sodium bicarbonate to react with compounds such as boric acid or alum. In liquid mixtures containing bismuth subnitrate, sodium bicarbonate reacts with the acid formed by hydrolysis of the bismuth salt.
In solution, sodium bicarbonate has been reported to be incompatible with many drug substances such as ciprofloxacin, amiodarone, nicardipine, and levofloxacin.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; ophthalmic preparations; oral capsules, solutions, and tablets). Included in parenteral (intravenous infusions and injections) and nonparenteral medicines (chewing gums; ear drops; eye lotions; oral capsules, chewable tablets, effervescent powders, effervescent tablets, granules, soluble tablets, orodispersible tablets, and tablets; suppositories and suspensions) licensed in the UK.

중탄산나트륨(중조) 준비 용품 및 원자재

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