CLOTIAZEPAM
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CLOTIAZEPAM 속성
- 녹는점
- 105-106°
- 끓는 점
- 523.7±50.0 °C(Predicted)
- 밀도
- 1.1625 (rough estimate)
- 굴절률
- 1.6100 (estimate)
- 용해도
- DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 2.36±0.20(Predicted)
안전
| 독성 | LD50 in mice (mg/kg): 440 i.p., 636 orally (Nakanishi) |
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CLOTIAZEPAM C화학적 특성, 용도, 생산
화학적 성질
Off-White Solid용도
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.CLOTIAZEPAM 준비 용품 및 원자재
원자재
아세트산(빙초산)
5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one
2-(Aminoacetylamino)-3-(o-chlorobenzoyl)-5-ethylthiophene
요오드 메탄