CLOTIAZEPAM
- CAS No.
- 33671-46-4
- Chemical Name:
- CLOTIAZEPAM
- Synonyms
- Rise;Rize;Rizen;Clozan;Tienor;Y 6047;Trecalmo;Veratran;CLOTIAZEPAM;Rize-13C,d3
- CBNumber:
- CB0487933
- Molecular Formula:
- C16H15ClN2OS
- Molecular Weight:
- 318.82
- MDL Number:
- MFCD00868176
- MOL File:
- 33671-46-4.mol
| Melting point | 105-106° |
|---|---|
| Boiling point | 523.7±50.0 °C(Predicted) |
| Density | 1.1625 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| solubility | DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| form | A crystalline solid |
| pka | 2.36±0.20(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | ZCN055599V |
| ATC code | N05BA21 |
CLOTIAZEPAM Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Rize,Yoshitomi,Japan,1979
Uses
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.
Definition
ChEBI: Clotiazepam is an organic molecular entity.
Manufacturing Process
To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a flask provided with a water-removing adaptor. The reaction mixture is concentrated, and the residue is extracted with chloroform. The chloroform layer is washed with water and then with a sodium hydrogen carbonate solution, then dried over magnesium sulfate. The chloroform is distilled off under reduced pressure, and toluene is added to the residue. Thus is precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro- 3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C.
Therapeutic Function
Tranquilizer
