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아세트산(빙초산)

아세트산(빙초산)
아세트산(빙초산) 구조식 이미지
카스 번호:
64-19-7
한글명:
아세트산(빙초산)
동의어(한글):
비네갈산;에탄오익산;에틸산;피롤리그너스산;글라시알아세트산;메탄카르복실산(METHANECARBOXYLICACID)ddddd;빙초산;빙초산10%;빙초산30%수용액;아세트산;아세트산(빙초산);초산;아세틱애씨드
상품명:
Acetic acid
동의어(영문):
HOAc;AcOH;vosol;cusuan;Aci-jel;CH3COOH;glacial;test111;Shotgun;Vinegar
CBNumber:
CB7854064
분자식:
C2H4O2
포뮬러 무게:
60.05
MOL 파일:
64-19-7.mol

아세트산(빙초산) 속성

녹는점
16.2 °C(lit.)
끓는 점
117-118 °C(lit.)
밀도
1.049 g/mL at 25 °C(lit.)
증기 밀도
2.07 (vs air)
증기압
11.4 mm Hg ( 20 °C)
굴절률
n20/D 1.371(lit.)
FEMA
2006 | ACETIC ACID
인화점
104 °F
저장 조건
Store below +30°C.
용해도
alcohol: miscible(lit.)
산도 계수 (pKa)
4.74(at 25℃)
물리적 상태
Solution
색상
colorless
Specific Gravity
1.0492 (20℃)
수소이온지수(pH)
3.91(1 mM solution);3.39(10 mM solution);2.88(100 mM solution);
pH 범위
2.4 (1.0M solution)
냄새
Strong, pungent, vinegar-like odor detectable at 0.2 to 1.0 ppm
Odor Threshold
0.006ppm
폭발한계
4-19.9%(V)
수용성
miscible
최대 파장(λmax)
λ: 260 nm Amax: 0.05
λ: 270 nm Amax: 0.02
λ: 300 nm Amax: 0.01
λ: 500 nm Amax: 0.01
Merck
14,55
JECFA Number
81
BRN
506007
Henry's Law Constant
133, 122, 6.88, and 1.27 at pH values of 2.13, 3.52, 5.68, and 7.14, respectively (25 °C, Hakuta et al., 1977)
노출 한도
TLV-TWA 10 ppm ~25 mg/m3) (ACGIH, OSHA, and MSHA); TLV-STEL 15 ppm (37.5 mg/m3) (ACGIH).
CAS 데이터베이스
64-19-7(CAS DataBase Reference)
NIST
Acetic acid(64-19-7)
EPA
Acetic acid (64-19-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 C,Xi
위험 카페고리 넘버 34-42-35-10-36/38
안전지침서 26-36/37/39-45-23-24/25
유엔번호(UN No.) UN 1792 8/PG 2
WGK 독일 3
RTECS 번호 NN1650000
F 고인화성물질 1-8-10
자연 발화 온도 426 °C
TSCA Yes
위험 등급 8
포장분류 II
HS 번호 29152100
유해 물질 데이터 64-19-7(Hazardous Substances Data)
독성 LD50 in rats (g/kg): 3.53 orally (Smyth)
IDLA 50 ppm
기존화학 물질 KE-00013
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H226 인화성 액체 및 증기 인화성 액체 구분 3 경고
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P310 즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405 밀봉하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
NFPA 704
2
3 0

아세트산(빙초산) MSDS


Acetic acid glacial

아세트산(빙초산) C화학적 특성, 용도, 생산

순도시험

  (1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 0.5ppm 이하이어야 한다.

  (3) 산화되기 쉬운 물질 : 이 품목 20mL에 0.1N 과망간산칼륨용액 0.3mL를 가할 때, 시액의 색은 30분 이내에 없어져서는 아니 된다.

  (4) 증발잔류물 : 「빙초산」의 순도시험 (6)에 따라 시험한다.

순도시험

  (1) 응고점 : 이 품목의 응고점은 14.5℃이상이어야 한다.

  (2) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 1.3ppm 이하이어야 한다.

  (3) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 0.5ppm 이하이어야 한다.

  (4) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

  (5) 산화되기 쉬운 물질 : 이 품목 2g을 물 10mL에 녹이고, 이에 0.1N 과망간산칼륨용액 0.1mL를 가할 때, 시액의 색이 30분 이내에 없어져서는 아니 된다.

  (6) 증발잔류물 : 이 품목 10g을 증발시킨 다음 100℃에서 2시간 건조할 때, 그 잔류물은 1mg 이하이어야 한다.

확인시험

  (1) 이 품목은 강산성이다.

  (2) 이 품목은 확인시험법 중 초산염의 반응을 나타낸다.

확인시험

  (1) 이 품목의 수용액(1→3)은 강산성이다.

  (2) 이 품목의 수용액(1→3)은 확인시험법 중 초산염의 반응을 나타낸다.

정량법

  이 품목 약 1g을 정밀히 달아 물 40mL를 가하고 1N 수산화나트륨용액으로 적정한다(지시약 : 페놀프탈레인시액 2방울).

1N 수산화나트륨용액 1mL = 60.05mg C2H4O2

정량법

  이 품목 약 3g을 정밀히 달아 물 15mL를 가하여 1N 수산화나트륨용액으로 적정한다(지시약 : 페놀프탈레인시액 2방울).

1N 수산화나트륨용액 1mL = 60.05mg C2H4O2

개요

Acetic acid is a colourless liquid or crystal with a sour, vinegar-like odour and is one of the simplest carboxylic acids and is an extensively used chemical reagent. Acetic acid has wide application as a laboratory reagent, in the production of cellulose acetate mainly for photographic film and polyvinyl acetate for wood glue, synthetic fibres, and fabric materials. Acetic acid has also been of large use as a descaling agent and acidity regulator in food industries.

물리적 성질

Acetic acid is a weak carboxylic acid with a pungent odor that exists as a liquid at room temperature. It was probably the first acid to be produced in large quantities. The name acetic comes from acetum, which is the Latin word for “sour” and relates to the fact that acetic acid is responsible for the bitter taste of fermented juices.

출처

Reported found in vinegar, bergamot, cornmint oil, bitter orange oil, lemon petitgrain, various dairy products

역사

Vinegar is a dilute aqueous solution of acetic acid. The use of vinegar is well documented in ancient history, dating back at least 10,000 years. Egyptians used vinegar as an antibiotic and made apple vinegar. Babylonians produced vinegar from wine for use in medicines and as a preservative as early as 5000 b.c.e. Hippocrates (ca. 460–377 b.c.e.), known as the “father of medicine,” used vinegar as an antiseptic and in remedies for numerous conditions including fever, constipation, ulcers, and pleurisy. Oxymel, which was an ancient remedy for coughs, was made by mixing honey and vinegar. A story recorded by the Roman writer Pliny the Elder (ca. 23–79 c.e.) describes how Cleopatra, in an attempt to stage the most expensive meal ever, dissolved pearls from an earring in vinegar wine and drank the solution to win a wager.

용도

Acetic acid is used as table vinegar, as preservative and as an intermediate in the chemical industry, e.g. acetate fibers, acetates, acetonitrile, pharmaceuticals, fragrances, softening agents, dyes (indigo) etc. Product Data Sheet

정의

ChEBI: A simple monocarboxylic acid containing two carbons.

일반 설명

A colorless aqueous solution. Smells like vinegar. Density 8.8 lb / gal. Corrosive to metals and tissue.

공기와 물의 반응

Dilution with water releases some heat.

반응 프로필

ACETIC ACID, [AQUEOUS SOLUTION] reacts exothermically with chemical bases. Subject to oxidation (with heating) by strong oxidizing agents. Dissolution in water moderates the chemical reactivity of acetic acid, A 5% solution of acetic acid is ordinary vinegar. Acetic acid forms explosive mixtures with p-xylene and air (Shraer, B.I. 1970. Khim. Prom. 46(10):747-750.).

위험도

Corrosive; exposure of small amounts can severely erode the lining of the gastrointestinal tract; may cause vomiting, diarrhea, bloody feces and urine; cardiovascular failure and death.

건강위험

Glacial acetic acid is a highly corrosive liquid. Contact with the eyes can produce mild to moderate irritation in humans. Contact with the skin may produce burns. Ingestion of this acid may cause corrosion of the mouth and gastrointestinal tract. The acute toxic effects are vomiting, diarrhea, ulceration, or bleeding from intestines and circulatory collapse. Death may occur from a high dose (20–30 mL), and toxic effects in humans may be felt from ingestion of 0.1–0.2 mL. An oral LD50 value in rats is 3530 mg/kg (Smyth 1956).
Glacial acetic acid is toxic to humans andanimals by inhalation and skin contact. Inhumans, exposure to 1000 ppm for a fewminutes may cause eye and respiratory tractirritation. Rabbits died from 4-hour exposureto a concentration of 16,000 ppm in air.

인화성 및 폭발성

Acetic acid is a combustible substance (NFPA rating = 2). Heating can release vapors that can be ignited. Vapors or gases may travel considerable distances to ignition source and "flash back." Acetic acid vapor forms explosive mixtures with air at concentrations of 4 to 16% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acetic acid fires.

Pharmaceutical Applications

Glacial and diluted acetic acid solutions are widely used as acidifying agents in a variety of pharmaceutical formulations and food preparations. Acetic acid is used in pharmaceutical products as a buffer system when combined with an acetate salt such as sodium acetate. Acetic acid is also claimed to have some antibacterial and antifungal properties.

농업용

Herbicide, Fungicide, Microbiocide; Metabolite, Veterinary Medicine: A herbicide used to control grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown; as a veterinary medicine.

상품명

ACETUM®; ACI-JEL®; ECOCLEAR®; NATURAL WEED SPRAY® No. One; VOSOL®

Safety Profile

A human poison by an unspecified route. Moderately toxic by various routes. A severe eye and skin irritant. Can cause burns, lachrymation, and conjunctivitis. Human systemic effects by ingestion: changes in the esophagus, ulceration, or bleeding from the small and large intestines. Human systemic irritant effects and mucous membrane irritant. Experimental reproductive effects. Mutation data reported. A common air contaminant. A flammable liquid. A fire and explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use CO2, dry chemical, alcohol foam, foam and mist. When heated to decomposition it emits irritating fumes. Potentially explosive reaction with 5azidotetrazole, bromine pentafluoride, chromium trioxide, hydrogen peroxide, potassium permanganate, sodium peroxide, and phosphorus trichloride. Potentially violent reactions with acetaldehyde and acetic anhydride. Ignites on contact with potassium tert-butoxide. Incompatible with chromic acid, nitric acid, 2-amino-ethanol, NH4NO3, ClF3, chlorosulfonic acid, (O3 + diallyl methyl carbinol), ethplenediamine, ethylene imine, (HNO3 + acetone), oleum, HClO4, permanganates, P(OCN)3, KOH, NaOH, xylene

Safety

Acetic acid is widely used in pharmaceutical applications primarily to adjust the pH of formulations and is thus generally regarded as relatively nontoxic and nonirritant. However, glacial acetic acid or solutions containing over 50% w/w acetic acid in water or organic solvents are considered corrosive and can cause damage to skin, eyes, nose, and mouth. If swallowed glacial acetic acid causes severe gastric irritation similar to that caused by hydrochloric acid.
Dilute acetic acid solutions containing up to 10% w/w of acetic acid have been used topically following jellyfish stings.Dilute acetic acid solutions containing up to 5% w/w of acetic acid have also been applied topically to treat wounds and burns infected with Pseudomonas aeruginosa.
The lowest lethal oral dose of glacial acetic acid in humans is reported to be 1470 mg/kg.The lowest lethal concentration on inhalation in humans is reported to be 816 ppm.Humans, are, however, estimated to consume approximately 1 g/day of acetic acid from the diet.
LD50 (mouse, IV): 0.525 g/kg
LD50 (rabbit, skin): 1.06 g/kg
LD50 (rat, oral): 3.31 g/kg

잠재적 노출

Acetic acid is widely used as a chemical feedstock for the production of vinyl plastics, acetic anhydride, acetone, acetanilide, acetyl chloride, ethyl alcohol, ketene, methyl ethyl ketone, acetate esters, and cellulose acetates. It is also used alone in the dye, rubber, pharmaceutical, food preserving, textile, and laundry industries. It is utilized, too; in the manufacture of Paris green, white lead, tint rinse, photographic chemicals, stain removers, insecticides, and plastics.

Carcinogenicity

Acetic acid is a very weak tumor promoter in a multistage mouse skin model for chemical carcinogenesis, but was very effective in enhancing cancer development when applied during the progression phase of the model. Female SENCAR mice were initiated with a topical application of 7,12-dimethylbenzanthracene and 2 weeks later were promoted with 12-O-tetradecanoylphorbol- 13-acetate, twice weekly for 16 weeks. Topical treatment with acetic acid started 4 weeks later (40 mg glacial acetic acid in 200mL acetone, twice weekly) and continued for 30 weeks. Before treatment with acetic acid, each group of mice had approximately the same number of papillomas at the exposure site. After 30 weeks of treatment, mice treated with acetic acid had a 55% greater conversion of skin papillomas to carcinomas than vehicle-treated mice. Selective cytotoxicity to certain cells within the papilloma and a compensatory increase in cell proliferation were considered the most probable mechanism.

환경귀착

Biological. Near Wilmington, NC, organic wastes containing acetic acid (representing 52.6% of total dissolved organic carbon) were injected into an aquifer containing saline water to a depth of approximately 1,000 feet below ground surface. The generation of gaseous components (hydrogen, nitrogen, hydrogen sulfide, carbon dioxide, and methane) suggests acetic acid and possibly other waste constituents, were anaerobically degraded by microorganisms (Leenheer et al., 1976).
Plant. Based on data collected during a 2-h fumigation period, EC50 values for alfalfa, soybean, wheat, tobacco, and corn were 7.8, 20.1, 23.3, 41.2, and 50.1 mg/m3, respectively (Thompson et al., 1979).
Photolytic. A photooxidation half-life of 26.7 d was based on an experimentally determined rate constant of 6 x 10-13 cm3/molecule?sec at 25 °C for the vapor-phase reaction of acetic acid with OH radicals in air (Atkinson, 1985). In an aqueous solution, the rate constant for the reaction of acetic acid with OH radicals was determined to be 2.70 x 10-17 cm3/molecule?sec (Dagaut et al., 1988).
Chemical/Physical. Ozonolysis of acetic acid in distilled water at 25 °C yielded glyoxylic acid which oxidized readily to oxalic acid before undergoing additional oxidation producing carbon dioxide. Ozonolysis accompanied by UV irradiation enhanced the removal of acetic acid (Kuo et al., 1977).

저장

Acetic acid should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

운송 방법

UN2789 Acetic acid, glacial or Acetic acid solution, with .80 % acid, by mass, hazard class: 8; labels: 8-Corrosive material, 3-flammable liquid. UN2790 acetic acid solution, not ,50% but not .80% acid, by mass, hazard class: 8; labels: 8-Corrosive material; acetic acid solution, with .10% and ,50%, by mass, hazard class: 8; labels: 8-Corrosive material

Purification Methods

Usual impurities are traces of acetaldehyde and other oxidisable substances and water. (Glacial acetic acid is very hygroscopic. The presence of 0.1% water lowers its m by 0.2o.) Purify it by adding some acetic anhydride to react with water present, heat it for 1hour to just below boiling in the presence of 2g CrO3 per 100mL and then fractionally distil it [Orton & Bradfield J Chem Soc 960 1924, Orton & Bradfield J Chem Soc 983 1927]. Instead of CrO3, use 2-5% (w/w) of KMnO4, and boil under reflux for 2-6hours. Traces of water have been removed by refluxing with tetraacetyl diborate (prepared by warming 1 part of boric acid with 5 parts (w/w) of acetic anhydride at 60o, cooling, and filtering off, followed by distillation [Eichelberger & La Mer J Am Chem Soc 55 3633 1933]. Refluxing with acetic anhydride in the presence of 0.2g % of 2-naphthalenesulfonic acid as catalyst has also been used [Orton & Bradfield J Chem Soc 983 1927]. Other suitable drying agents include anhydrous CuSO4 and chromium triacetate: P2O5 converts some acetic acid to the anhydride. Azeotropic removal of water by distillation with thiophene-free *benzene or with butyl acetate has been used [Birdwhistell & Griswold J Am Chem Soc 77 873 1955]. An alternative purification uses fractional freezing. [Beilstein 2 H 96, 2 IV 94.] Rapid procedure: Add 5% acetic anhydride, and 2% of CrO3. Reflux and fractionally distil.

비 호환성

Acetic acid reacts with alkaline substances.

폐기물 처리

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, ophthalmic, and oral preparations). Included in parenteral and nonparenteral preparations licensed in the UK.

아세트산(빙초산) 준비 용품 및 원자재

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