자테브라딘
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자테브라딘 속성
- 끓는 점
- 612.5±55.0 °C(Predicted)
- 밀도
- 1.115±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO : ≥ 50 mg/mL (109.51 mM)
- 산도 계수 (pKa)
- 8.99±0.50(Predicted)
- 물리적 상태
- Oil
- 색상
- Light brown to brown
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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유해·위험 문구: |
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예방조치문구: |
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자테브라딘 C화학적 특성, 용도, 생산
Originator
ZATEBRADINE HYDROCHLORIDE,Boenhringer IngelheimManufacturing Process
A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3- (N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar. After the catalyst had been filtered off, the solvent was evaporated in vacuum, and the residue was taken up in methylene chloride. After the solution had been extracted with an aqueous sodium bicarbonate solution and washed with water, it was dried over magnesium sulfate, evaporated and purified over silica gel with methylene chloride and then with increasing amounts of methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of theory. Melting point: 110°C (dec.).1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of 3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10 mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring was continued for 48 h at room temperature. After evaporating the solution in vacuum, the residue was taken up in dilute hydrochloric acid and extracted twice with ether. Subsequently, the aqueous phase was made alkaline and extracted three times with methylene chloride, and the organic phase was evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5- tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4- dimethoxyphenyl}ethyl)amino]propane was obtained.
Therapeutic Function
Bradycardic자테브라딘 준비 용품 및 원자재
원자재
준비 용품
자테브라딘 공급 업체
글로벌( 34)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9316 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 |
mychess007@163.com | China | 1994 | 55 |
LETOPHARM LIMITED | +86-21-5821 5861 |
sales@letopharm.com | China | 2384 | 58 |
Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 |
505721671@qq.com | China | 3868 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 4182 | 55 |
자테브라딘 관련 검색:
NIZA티딘
3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
Cetirizine
Ivabradine
(S)-(+)-7,8-DIMETHOXY-3-[[1-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-PIPERIDINYL]METHYL]-1,3,4,5-TETRAHYDRO-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
Ivabradine hydrochloride
Zatebradine
Cilobradine