GRAMICIDIN
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GRAMICIDIN 속성
- 녹는점
- 229-230℃
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않으며, 메탄올에 녹고, 알코올에는 거의 녹지 않습니다.
- 색상
- 흰색에서 황백색까지
- 수용성
- 아세트산 및 저급 알코올에 용해됩니다. 물에 거의 녹지 않습니다.
- InChIKey
- ZWCXYZRRTRDGQE-SORVKSEFSA-N
- CAS 데이터베이스
- 1405-97-6
안전
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21-36/37/38 | ||
안전지침서 | 26-36-24/25-22 | ||
WGK 독일 | 3 | ||
RTECS 번호 | MD8225000 | ||
HS 번호 | 2941906000 | ||
독성 | mouse,LD50,intravenous,1500ug/kg (1.5mg/kg),Science. Vol. 103, Pg. 419, 1946. |
GRAMICIDIN C화학적 특성, 용도, 생산
개요
Gramicidin is a polypeptide antibiotic mixture of gramicidin A , gramicidin B, and gramicidin C originally isolated from B. brevis. It is also a component of the antibiotic tyrothricin . Gramicidin is active against the Gram-positive bacterium S. aureus but not Gram-negative E. coli. It also protects mice from Pneumococcus infection in vivo when administered at a dose of 0.002 mg/animal. Gramicidin inhibits growth of bacteria by forming pores and channels in the cell wall, which increases its permeability to monovalent cations. Formulations containing gramicidin have been used as topical agents in the treatment of bacterial skin infections.화학적 성질
White, crystalline platelets. Soluble in lower alcohols, acetic acid, and pyridine; moderately soluble in dry acetone and dioxane; almost insoluble in water, ether, and hydrocarbons. Depresses surface tension, forms a fairly stable colloidal emulsion in distilled water.용도
Gramicidins are a family of linear pentadecapeptides isolated from Bacillus brevis by Dubos at the Rockefeller Institute in 1939. Gramicidin is a complex of six closely related analogues A1, A2, B1, B2, C1 and C2 where A1 and A2 are the dominant components. Gramidicins act by forming channels in cell membranes causing ion leakage, and is an essential bioprobe for understanding the nature of the cell membranes.정의
An antibiotic produced by the metabolic processes of the bacteria Bacillus brevis. It is a polypeptide that is active against most Gram-positive pathogenic bacteria. It is one of the two antibiotic components of tyrothricin but has been isolated and used일반 설명
Gramicidin is obtained from tyrothricin, a mixture ofpolypeptides usually obtained by extraction of cultures of B.brevis. Tyrothricin was isolated in 1939 by Dubos in aplanned search to find an organism growing in soil that wouldhave antibiotic activity against human pathogens. With onlylimited use in therapy now, it is of historical interest as thefirst in the series of modern antibiotics. Tyrothricin is a whiteto slightly gray or brown-white powder, with little or no odoror taste. It is practically insoluble in water and is soluble in alcoholand dilute acids. Suspensions for clinical use can beprepared by adding an alcoholic solution to calculatedamounts of distilled water or isotonic saline solutions.Gramicidin acts as an ionophore in bacterial cell membranesto cause the loss of potassium ion from the cell. Itis bactericidal.Tyrothricin and gramicidin are effective primarilyagainst Gram-positive organisms. Their use is restricted tolocal applications. Tyrothricin can cause lysis of erythrocytes,which makes it unsuitable for the treatment of systemicinfections. Its applications should avoid direct contactwith the bloodstream through open wounds or abrasions. Itis ordinarily safe to use tyrothricin in troches for throat infections,as it is not absorbed from the GI tract. Gramicidinis available in various topical preparations containing otherantibiotics, such as bacitracin and neomycin.
Pharmaceutical Applications
Gramicidin as used in topical formulations is a mixture of several closely related compounds, of which about 80% is in the form of gramicidin A. It is part of the tyrothricin complex originally isolated from B. brevis.It is active against most species of Gram-positive bacteria, including mycobacteria. Gram-negative bacilli are completely insensitive.
It is highly toxic to erythrocytes, liver and kidney, and is used only in topical formulations, usually as one of several components.
GRAMICIDIN 준비 용품 및 원자재
원자재
준비 용품
GRAMICIDIN 공급 업체
글로벌( 135)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3422 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
GRAMICIDIN 관련 검색:
Gramicidin/CH63857,gramicidin from bacillus brevis,GRAMICIDIN D,GRAMICIDIN,GRAMICIDIN D [DUBOS],Gramicidin >95%
GRAMICIDIN A FROM BACILLUS BREVIS,GRAMICIDIN A, BACILLUS BREVIS,GRAMICIDIN A
GRAMICIDIN C,Gramicidin S1,Gramicidin S-A,Soviet Gramicidin C,GRAMICIDIN S
GRAMICIDIN C FROM BACILLUS BREVIS
Gramicidin S hydrochloride
Gramicidin A, High Purity, Bacillus brevis
Gramicidin USP25
malonyl gramicidin
N,N'-diformyl gramicidin S
des(formylvalyl)gramicidin
gramicidin-S-synthetase 2
gramicidin(micro) usp23,
Gramicidin S2
gramicidin A, 7,8-des-Val-
gramicidin A, 7-alanine-
[Val1]gramicidin A,Gramicidin A 1-L-Val
(4,4'-dehydrophenylalanine)gramicidin S
des(ethanolamine)taurine(16)-gramicidin A