Propagermanium, the first organogermanium compound marketed as a
pharmaceutical, is indicated for the oral treatment of chronic hepatitis B.
Propagermanium is reported to enhance production of interferon α/β in virus infected
mice and in human peripheral blood mononuclear cells but does not inhibit the growth
of various DNA or RNA viruses in vitro. Therefore, enhancement of the host immune
system against virus infection was proposed to be responsible for its antiviral
activity. Propagermanium also exhibits potent antitumor activity, reportedly via
stimulation of T lymphocytes to produce a lyrnphokine (s), possibly interferon-y,
which induces the generation and activation of cytotoxic macrophages leading to
elimination of tumor cells. Propagermanium has been reported to regulate calcium
metabolism and to alleviate cancerous pain and osteocope.
용도
antifungal and antiseptic
일반 설명
Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.
Safety Profile
Moderately toxic by
intravenous route. Experimental
reproductive effects. See also
GERMANIUM COMPOUNDS.
