METHACHOLINE CHLORIDE

METHACHOLINE CHLORIDE 구조식 이미지
카스 번호:
62-51-1
상품명:
METHACHOLINE CHLORIDE
동의어(영문):
amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
CBNumber:
CB2316248
분자식:
C8H18ClNO2
포뮬러 무게:
195.69
MOL 파일:
62-51-1.mol
MSDS 파일:
SDS

METHACHOLINE CHLORIDE 속성

녹는점
171-173 °C(lit.)
밀도
1.1028 (rough estimate)
굴절률
1.5790 (estimate)
저장 조건
-20°C
용해도
H2O: 50 mg/mL, 투명, 무색
물리적 상태
가루
색상
흰색에서 거의 흰색
수소이온지수(pH)
3.0~7.0 (50g/l, 25℃)
수용성
거의 투명함
Merck
14,5940
BRN
4162373
안정성
불안정 - 습기에 민감함. 산화제와 호환되지 않습니다.
LogP
-3.957 (est)
CAS 데이터베이스
62-51-1
EPA
1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 BR5250000
F 고인화성물질 3-10-21
HS 번호 29239000
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

METHACHOLINE CHLORIDE C화학적 특성, 용도, 생산

화학적 성질

colourless to white crystalline powder with a slight

용도

antihypertensive, antianginal

일반 설명

Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.

Clinical Use

Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.

Purification Methods

It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]

METHACHOLINE CHLORIDE 준비 용품 및 원자재

원자재

준비 용품


METHACHOLINE CHLORIDE 공급 업체

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Alfa Chemistry

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Aston Chemical
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Dayang Chem (Hangzhou) Co.,Ltd.
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GIHI CHEMICALS CO.,LIMITED
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Shanghai Acmec Biochemical Technology Co., Ltd.
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product@acmec-e.com China 33350 58
Aladdin Scientific
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sales@aladdinsci.com United States 57511 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40068 58

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