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이소프로필알코올

이소프로필알코올
이소프로필알코올 구조식 이미지
카스 번호:
67-63-0
한글명:
이소프로필알코올
동의어(한글):
이소프로필알코올;에틸카르비놀;이소올;제록스필름제거제;2-프로판올;SEC-프로필알코올;디메틸카르비놀;아이소프로필알코올;이소프로판올;프로판-2-올;프로필알코올;아이피에이;이소프로필알콜;이소프로필알코올;아이소프로판올;1-메틸에탄올;1-메틸에틸알코올;2-프로필알코올;2-하이드록시프로페인;n-프로판-2-올
상품명:
Isopropyl alcohol
동의어(영문):
IPA;iPrOH;I.P.S.;imsola;Isohol;Propol;i-PrOH;CI 764;Alcolo;Avantin
CBNumber:
CB8854102
분자식:
C3H8O
포뮬러 무게:
60.1
MOL 파일:
67-63-0.mol

이소프로필알코올 속성

녹는점
-89.5 °C
끓는 점
82 °C(lit.)
밀도
0.785 g/mL at 25 °C(lit.)
증기 밀도
2.1 (vs air)
증기압
33 mm Hg ( 20 °C)
굴절률
n20/D 1.377(lit.)
FEMA
2929 | ISOPROPYL ALCOHOL
인화점
53 °F
저장 조건
Store at +5°C to +30°C.
용해도
water: soluble (completely)
산도 계수 (pKa)
17.1(at 25℃)
물리적 상태
Low Melting Solid
Specific Gravity
approximate 0.785(20/20℃)(Ph.Eur.)
색상
colorless
상대극성
0.546
냄새
Like ethyl alcohol; sharp, somewhat unpleasant; characteristic mild alcoholic; nonresidual.
Odor Threshold
26ppm
폭발한계
2-13.4%(V)
수용성
miscible
어는점
-89.5℃
최대 파장(λmax)
λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01
Merck
14,5208
JECFA Number
277
BRN
635639
노출 한도
TLV-TWA 980 mg/m3 (400 ppm); STEL 1225 mg/m3 (500 ppm) (ACGIH); IDLH 12,000 ppm (NIOSH).
CAS 데이터베이스
67-63-0(CAS DataBase Reference)
NIST
Isopropyl alcohol(67-63-0)
IARC
3 (Vol. 15, Sup 7, 71) 1999
EPA
Isopropanol (67-63-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,F,Xn
위험 카페고리 넘버 11-36-67-40-10-36/38
안전지침서 7-16-24/25-26-36/37
유엔번호(UN No.) UN 1219 3/PG 2
WGK 독일 1
RTECS 번호 NT8050000
F 고인화성물질 3-10
자연 발화 온도 750 °F
TSCA Yes
HS 번호 2905 12 00
위험 등급 3
포장분류 II
유해 물질 데이터 67-63-0(Hazardous Substances Data)
독성 LD50 orally in rats: 5.8 g/kg (Smyth, Carpenter)
기존화학 물질 KE-29363
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H336 졸음 또는 현기증을 일으킬 수 있음 특정표적장기 독성 물질(1회 노출);마취작용 구분 3 경고 P261, P271, P304+P340, P312,P403+P233, P405, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405 밀봉하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
NFPA 704
3
1 0

이소프로필알코올 C화학적 특성, 용도, 생산

물성

Iso-Propyl Alcohol (IPA) 2-Propanol, sec-Propyl alcohol, 이소 프로필 알코올, 이소프로판올 다른 이름; 강한 냄새가 나는 무색의 가연성 화합물입니다. 그것은 1- 프로판올의 구조 이성질체이다. 대다수의 IPA는 코팅 또는 산업 공정 용 용매로 사용되었습니다.

개요

아이소프로필 알코올(isopropyl alcohol) 또는 프로판-2-올(propan-2-ol), 2-프로판올(2-propanol)은 분자식 C3H8O의 화학 약품으로, 무색이며, 인화성을 가지는 약품이다. 무극성 물질을 용해하며 자기 얼룩을 남기지 않고 쉽게 증발하는 특징이 있어 반도체, LCD 등 IT 부품 세정액으로 많이 활용되며, 페인트, 잉크 등의 용제로도 사용되는 강한 알콜향의 무색 유기 용제이다.

용도

이소 프로필 알코올 (Iso-Propyl Alcohol, IPA)은 화장품, 피부 및 모발 준비 용품, 의약품, 향수, 래커 제형, 염료 용액, 부동액, 비누, 창문 세척제의 소비자 용도로 주로 제조됩니다. 산업 응용 분야는 접착제 및 실란트 화학 물질, 비 살충 농약, 연료 및 연료 첨가제, 중간체, 윤활제, 페인트 및 코팅 첨가제, 석유 생산 관련 프로세스 조정자 및 보조 장치 및 세척 또는 탈지 용 세정제를 포함합니다.

제품 소개

이소 프로필 알코올 (Iso-Propyl Alcohol, IPA)은 화장품, 피부 및 모발 준비 용품, 의약품, 향수, 래커 제형, 염료 용액, 부동액, 비누, 창문 세척제의 소비자 용도로 주로 제조됩니다. 

개요

Isopropanol is a clear, colorless alcohol that is used in the production of acetone and as a solvent in the manufacture of various industrial and commercial products. It is used by the public for a number of different purposes and is commonly known as rubbing alcohol. It is flammable and miscible with both water and many different organic solvents. Isopropanol can be prepared via three different methods: indirect hydration of propylene (the ‘strong acid’ method), direct hydration of propylene, and catalytic hydrogenation of acetone.

화학적 성질

Isopropyl alcohol is a clear, colorless, mobile, volatile, flammable liquid with a characteristic, spirituous odor resembling that of a mixture of ethanol and acetone; it has a slightly bitter taste.It is miscible with water, ethyl ether, and ethyl alcohol. Isopropyl alcohol is incompatible with strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates.

출처

Reported found in apple and cognac aromas (esterified). Also found in apple, banana, grapefruit and lime juice, melon, papaya, pear, onion, peas, rutabaga, tomato, wheat bread, cheeses, milk, boiled egg, cooked beef, pork and mutton, hop oil beer, rum, cocoa, coffee, scotch whiskey, grape wines, peanut, pecan, soybean, honey, beans, plum brandy, walnut, crab, clam, prickly pear and clary sage.

용도

Isopropyl alcohol is used in the production of acetone, isopropyl halides, glycerin, and aluminum isopropoxide; employed widely as an industrial solvent for paints, polishes, and insecticides; as an antiseptic (rubbing alcohol); and in organic synthesis for introducing the isopropyl or isopropoxy group into the molecule. Being a common laboratory solvent like methanol, the exposure risks are always high; however, its toxicity is comparatively low.

용도

isopropyl alcohol is a carrier, anti-bacterial, and solvent for skin care lotions. Isopropyl alcohol is made from propylene, a petroleum derivative.

용도

In antifreeze compositions; as solvent for gums, shellac, essential oils; in the extraction of alkaloids; in quick-drying oils; in quick-drying inks; in denaturing ethyl alcohol; in body rubs; hand lotions, after-shave lotions and similar cosmetics. Solvent for creosote, resins, gums; in manufacture of acetone, glycerol, isopropyl acetate. Pharmaceutic aid (solvent).

용도

When compared to ethanol, 50% less is required for nucleic acid precipitation, thus minimizing the total volume to be centrifuged for DNA or RNA recovery.

용도

Suitable for HPLC, spectrophotometry, environmental testing

정의

ChEBI: A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.

생산 방법

Two basic methods of production are in commercial use: (1) absorption of propylene in sulfuric acid to form alkyl hydrogen sulfate, followed by the hydrolysis of the ester; and (2) by direct hydration with water, using a catalyst. An inherent disadvantage in the first process is the need to handle sulfuric acid. Further, the first process yields little more than 70% isopropanol as compared with the second process, in which liquid propylene is used as the charge stock. All direct-hydration processes can be represented by: C3H6 + H2O ??→ C3H7OH + heat.

생산 방법

Isopropyl alcohol may be prepared from propylene; by the catalytic reduction of acetone, or by fermentation of certain carbohydrates.

Aroma threshold values

Detection: 40 to 601 ppm

일반 설명

Volatile, colorless liquid with a sharp musty odor like rubbing alcohol. Flash point of 53°F. Vapors are heavier than air and mildly irritating to the eyes, nose, and throat. Density approximately 6.5 lb / gal. Used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, soaps, window cleaners. Sold in 70% aqueous solution as rubbing alcohol.

공기와 물의 반응

Highly flammable. Water soluble.

반응 프로필

Isopropanol reacts with air or oxygen to form dangerously unstable peroxides. Contact with 2-butanone increases the rate of peroxide formation. An explosive reaction occurs when Isopropanol is heated with (aluminum isopropoxide + crotonaldehyde). Forms explosive mixtures with trinitromethane and hydrogen peroxide. Reacts with barium perchlorate to form a highly explosive compound. Ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide and potassium-tert-butoxide. Vigorous reactions occur with (hydrogen + palladium), nitroform, oleum, COCl2, aluminum triisopropoxide and oxidizing agents. Reacts explosively with phosgene in the presence of iron salts. Incompatible with acids, acid anhydrides, halogens and aluminum . Isopropanol can react with PCl3, forming toxic HCl gas. (Logsdon, John E., Richard A. Loke., sopropyl Alcohol. Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 1996.).

위험도

Flammable, dangerous fire risk, explosive limits in air 2–12%. Toxic by ingestion and inhalation. Eye and upper respiratory tract irritant, central nervous system impairment. Questionable carcinogen.

건강위험

Exposures to isopropyl alcohol cause irritation to the eyes and mucous membranes. Exposures to isopropyl alcohol for 3–5 min (400 ppm) caused mild irritation of the eyes, nose, and throat, and at 800 ppm these symptoms became severe. Ingestion or an oral dose of 25 mL in 100 mL of water produced hypotension, facial fl ushing, bradycardia, and dizziness. Ingestion in large quantities caused extensive hemorrhagic tracheobronchitis, bronchopneumonia, and hemorrhagic pulmonary edema. Prolonged skin contact with isopropyl alcohol caused eczema and sensitivity. Delayed dermal absorption is attributed to a number of pediatric poisonings that have occurred following repeated or prolonged sponge bathing with isopropyl alcohol to reduce fever. In several cases, symptoms included respiratory distress, stupor, and coma. Laboratory animals exposed to isopropyl alcohol develop poisoning with symptoms of hind leg paralysis, unsteadiness, lack of muscular coordination, respiratory depression, and stupor. Isopropyl alcohol is a potent CNS depressant, and in large doses causes cardiovascular depression.

화재위험

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

화학 반응

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Pharmaceutical Applications

Isopropyl alcohol (propan-2-ol) is used in cosmetics and pharmaceutical formulations, primarily as a solvent in topical formulations.( It is not recommended for oral use owing to its toxicity.
Although it is used in lotions, the marked degreasing properties of isopropyl alcohol may limit its usefulness in preparations used repeatedly. Isopropyl alcohol is also used as a solvent both for tablet film-coating and for tablet granulation, where the isopropyl alcohol is subsequently removed by evaporation. It has also been shown to significantly increase the skin permeability of nimesulide from carbomer 934.
Isopropyl alcohol has some antimicrobial activity and a 70% v/v aqueous solution is used as a topical disinfectant. Therapeutically, isopropyl alcohol has been investigated for the treatment of postoperative nausea or vomiting.

Safety

Isopropyl alcohol is widely used in cosmetics and topical pharmaceutical formulations. It is readily absorbed from the gastrointestinal tract and may be slowly absorbed through intact skin. Prolonged direct exposure of isopropyl alcohol to the skin may result in cardiac and neurological deficits. In neonates, isopropyl alcohol has been reported to cause chemical burns following topical application.
Isopropyl alcohol is metabolized more slowly than ethanol, primarily to acetone. Metabolites and unchanged isopropyl alcohol are mainly excreted in the urine.
Isopropyl alcohol is about twice as toxic as ethanol and should therefore not be administered orally; isopropyl alcohol also has an unpleasant taste. Symptoms of isopropyl alcohol toxicity are similar to those for ethanol except that isopropyl alcohol has no initial euphoric action, and gastritis and vomiting are more prominent; see Alcohol. Delta osmolality may be useful as rapid screen test to identify patients at risk of complications from ingestion of isopropyl alcohol. The lethal oral dose is estimated to be about 120–250mL although toxic symptoms may be produced by 20 mL.
Adverse effects following parenteral administration of up to 20mL of isopropyl alcohol diluted with water have included only a sensation of heat and a slight lowering of blood pressure. However, isopropyl alcohol is not commonly used in parenteral products.
Although inhalation can cause irritation and coma, the inhalation of isopropyl alcohol has been investigated in therapeutic applications.
Isopropyl alcohol is most frequently used in topical pharmaceutical formulations where it may act as a local irritant. When applied to the eye it can cause corneal burns and eye damage.
LD50 (dog, oral): 4.80 g/kg
LD50 (mouse, oral): 3.6 g/kg
LD50 (mouse, IP): 4.48 g/kg
LD50 (mouse, IV): 1.51 g/kg
LD50 (rabbit, oral): 6.41 g/kg
LD50 (rabbit, skin): 12.8 g/kg
LD50 (rat, IP): 2.74 g/kg
LD50 (rat, IV): 1.09 g/kg
LD50 (rat, oral): 5.05 g/kg

Chemical Synthesis

Synthetically prepared from acetylene or propylene.

Carcinogenicity

CD-1 mice were exposed by inhalation to 0, 500, 2500, or 5000 ppm of isopropanol vapor for 6 h/day, 5 days/week for 18 months. An additional group of mice (all exposure levels) were assigned to a recovery group that were exposed to isopropanol for 12 months and then retained until study termination at 18 months. There was no increased frequency of neoplastic lesions in any of the isopropanol-exposed animals. Nonneoplastic lesions were limited to the testes (males) and the kidney. In the testes, enlargement of the seminal vesicles occurred in the absence of associated inflammatory or degenerative changes. The kidney effects included tubular proteinosis and/or tubular dilatation. The incidence of testicular and kidney effects was not increased in the isopropanol-exposed recovery animals.

환경귀착

The vast majority of isopropanol in the environment originates from manufacturing processes. Small amounts are produced by certain microbes, fungi, and yeast. The high volatility of isopropanol ensures that when it is released into the environment in any state, it eventually ends up in the atmosphere. There, it can be degraded by hydroxyl radicals or it can return to soil or water through precipitation. Its half-life in the environment is approximately 3.2 days and is highly biodegradable; bioaccumulation in plants and animals does not occur.

저장

Isopropyl alcohol should be stored in a cool, dry, well-ventilated area in tightly sealed containers with a proper label. Outside or detached storage is preferable. Inside storage should be a flammable liquids storage room or cabinet. Workers should not store isopropyl alcohol above 37°C (100°F). Containers of isopropyl alcohol should be protected from physical damage and contact with air, and should be stored separately from strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates. Isopropyl alcohol should be transported to the nearest laboratory as quickly as possible in cool containers.

Purification Methods

Isopropyl alcohol is prepared commercially by dissolution of propene in H2SO4, followed by hydrolysis of the sulfate ester. Major impurities are water, lower alcohols and oxidation products such as aldehydes and ketones. Purification of isopropanol follows substantially the same procedure as for n-propyl alcohol. Isopropanol forms a constant-boiling mixture, b 80.3o, with water. Most of the water can be removed from this 91% isopropanol by refluxing with CaO (200g/L) for several hours, then distilling. The distillate can be dried further with CaH2, magnesium ribbon, BaO, CaSO4, calcium, anhydrous CuSO4 or Linde type 5A molecular sieves. Distillation from sulfanilic acid removes ammonia and other basic impurities. Peroxides [indicated by liberation of iodine from weakly acid (HCl) solutions of 2% KI] can be removed by refluxing with solid stannous chloride or with NaBH4 then the alcohol is fractionally distilled. To obtain isopropanol containing only 0.002M of water, sodium (8g/L) is dissolved in material dried by distillation from CaSO4. Isopropyl benzoate (35mL) is then added and, after refluxing for 3hours, the alcohol is distilled through a 50-cm Vigreux column (p 11). [Hine & Tanabe J Am Chem Soc 80 3002 1958.] Other purification steps for isopropanol include refluxing with solid aluminium isopropoxide, refluxing with NaBH4 for 24hours, and removing acetone by treatment with, and distillation from, 2,4-dinitrophenylhydrazine. Peroxides re-form in isopropanol if it is kept for several days in contact with air. [Beilstein 1 IV 1461.]

Toxicity evaluation

Isopropanol is similar to other alcohols in its ability to induce central nervous system (CNS) depression by enhancing inhibitory neuronal activity and antagonizing excitatory neuronal activity. It also can cause localized irritation upon contact with skin and mucous membranes after dermal exposure and ingestion, respectively.

비 호환성

Incompatible with oxidizing agents such as hydrogen peroxide and nitric acid, which cause decomposition. Isopropyl alcohol may be salted out from aqueous mixtures by the addition of sodium chloride, sodium sulfate, and other salts, or by the addition of sodium hydroxide.

주의 사항

Workers should wash hands and face thoroughly after handling isopropyl alcohol. Workers should wear gloves, safety glasses and a face shield, boots, apron, and a full impermeable suit is recommended if exposure is possible to a large portion of the body.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, tablets, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

이소프로필알코올 준비 용품 및 원자재

원자재

준비 용품


이소프로필알코올 공급 업체

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