LITHOCHOLIC ACID
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LITHOCHOLIC ACID 속성
- 녹는점
- 183-188 °C (lit.)
- 알파
- D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
- 끓는 점
- 445.09°C (rough estimate)
- 밀도
- 1.0454 (rough estimate)
- 굴절률
- 35.5 ° (C=1, EtOH)
- 인화점
- 9℃
- 저장 조건
- room temp
- 용해도
- 클로로포름(약간 용해됨), 디클로로메탄(약간 용해됨, 가온), DMSO(약간 용해됨, 가온)
- 산도 계수 (pKa)
- 4.76±0.10(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 18.83ug/L(25℃)
- Merck
- 5545
- BRN
- 3217757
- InChIKey
- SMEROWZSTRWXGI-HVATVPOCSA-N
- LogP
- 6.700 (est)
- CAS 데이터베이스
- 434-13-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| 유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | FZ2275000 | ||
| HS 번호 | 29181998 | ||
| 유해 물질 데이터 | 434-13-9(Hazardous Substances Data) |
LITHOCHOLIC ACID C화학적 특성, 용도, 생산
화학적 성질
white to off-white powder용도
Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.정의
ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.일반 설명
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.공기와 물의 반응
Insoluble in water.건강위험
ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.화재위험
Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.Purification Methods
Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]LITHOCHOLIC ACID 준비 용품 및 원자재
원자재
Chola-4,22-dien-24-oic acid, 3-oxo-, ethyl ester, (22E)-
3α-Acetoxy-5β-cholan-24-oic acid methyl ester
준비 용품
LITHOCHOLIC ACID 공급 업체
글로벌( 348)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Xinyi Dajiang Chemical Co.,Ltd. | +8617314178111 |
243096958@qq.com | China | 5 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1532 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 |
admin@hbsaisier.cn | China | 747 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
LITHOCHOLIC ACID 관련 검색:
우르소데옥시콜산 염소 산 하이오디옥시콜산 나트륨 콜산염 나트륨 데스옥시클로산
Deoxycholic acid
Allo-UDCA
(4R)-4-[(3S,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
3-ALPHA-HYDROXY-6-KETOCHOLANIC ACID
(+)-NEOMENTHOL
(2R,5S)-5-(5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
(2S)-2-[[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-1,3-oxathiolan-5-ol 5-Acetate
Emtricitabine Impurity 18
5-fluoro-1-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)cytosine
5-epi EMtricitabine
2,4(1H,3H)-Pyrimidinedione,5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)- (9CI)
Emtricitabine
Emtricitabine Impurity 8