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LITHOCHOLIC ACID

LITHOCHOLIC ACID
LITHOCHOLIC ACID structure
CAS No.
434-13-9
Chemical Name:
LITHOCHOLIC ACID
Synonyms
NCI-C03861;NCI-CO-3861;Lithocholate;Lithocolic acid;LITHOCHOLIC ACID;Lithocholic aCld;Stone cholic acid;Lithocholic Acide;HYDROYCHOLANIC ACID;Lithocholic acid,98%
CBNumber:
CB2342229
Molecular Formula:
C24H40O3
Formula Weight:
376.57
MOL File:
434-13-9.mol

LITHOCHOLIC ACID Properties

Melting point:
183-188 °C(lit.)
alpha 
D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
Boiling point:
445.09°C (rough estimate)
Density 
1.0454 (rough estimate)
refractive index 
35.5 ° (C=1, EtOH)
Flash point:
9℃
storage temp. 
Refrigerator
form 
Powder
color 
White to off-white
Merck 
5545
BRN 
3217757
InChIKey
SMEROWZSTRWXGI-HVATVPOCSA-N
CAS DataBase Reference
434-13-9(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Safety Statements  22-24/25
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  FZ2275000
HS Code  29181998
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

LITHOCHOLIC ACID price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L-042 Lithocholic acid 50 μg/mL in methanol, certified reference material 434-13-9 042-1ml $49 2018-11-13 Buy
Sigma-Aldrich L6250 Lithocholic acid ≥95% 434-13-9 10g $54.1 2018-11-13 Buy
Cayman Chemical 20253 Lithocholic Acid ≥95% 434-13-9 5g $25 2018-11-19 Buy
Cayman Chemical 20253 Lithocholic Acid ≥95% 434-13-9 10g $43 2018-11-19 Buy
Sigma-Aldrich L6250 Lithocholic acid ≥95% 434-13-9 25g $117 2018-11-13 Buy

LITHOCHOLIC ACID Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.

Uses

LD50(mouse) 3900 mg/kg po

Uses

Cholagogue;Anticholelithogenic

Definition

ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.

General Description

Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.

Air & Water Reactions

Insoluble in water.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.

Fire Hazard

Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.

Purification Methods

Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]

LITHOCHOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products


LITHOCHOLIC ACID Suppliers

Global( 147)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3624 58
Wuhan Netcom Electronic Commerce Limited 18024945277
0757-22902452 2355935187@ycphar.com China 5091 58
Shanghai QianJin Chemical Technology Co., Ltd 021-20900665,17321230821
021-20900665 shqjchemical@163.com China 1695 55

View Lastest Price from LITHOCHOLIC ACID manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 LITHOCHOLIC ACID
434-13-9
US $1.00 / KG 1g 99% 100KG career henan chemical co

LITHOCHOLIC ACID Spectrum


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