Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist
introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma
and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting
than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to
be the first bronchodilator with significant anti-inflammatory activity and hence could
complement prophylactic corticosteroid therapy.
화학적 성질
White to Off-White Solid
용도
A ?-Adrenergic agonist. Structural analog of albuterol
주요 응용
Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).
